Homocysteine remethylation in young broilers fed varying levels of methionine, choline, and betaine

Poultry Science

Volumn 85, Issue 1, 2006, Pages 90-95

  Pillai, P B ^a   Fanatico, A C ^a   Beers, K W ^b   Blair, M E ^c   Emmert, J L ^a  

^a UNIVERSITY OF ARKANSAS   (United States)

^b Safe Foods Inc   (United States)

^c Adisseo Inc   (United States)

Author keywords

Broiler; Homocysteine; Methionine; Remethylation

Indexed keywords

AVES; GALLUS GALLUS;

BETAINE; CHOLINE; HOMOCYSTEINE; METHIONINE;

ANIMAL; ARTICLE; CHICKEN; CLINICAL TRIAL; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHYLATION;

ANIMALS; BETAINE; CHICKENS; CHOLINE; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HOMOCYSTEINE; METHIONINE; METHYLATION;

EID: 33645799440     PISSN: 00325791     EISSN: 15253171     Source Type: Journal    
DOI: 10.1093/ps/85.1.90     Document Type: Article

References (23)

1. Barnes, D., Z. Song, and W. Bottje, 1999. A stable isotope method for the study of protein and sulfur amino acid metabolism in vivo. Poult. Sci. 78(Suppl. 1):33. (Abstr.)
2. Cao, Z., H. Cai, and C. N. Coon. 1995. Methionine and cystine requirements and metabolism for layers and broilers. Pages 257-289 in Proc. Minnesota Nutr. Conf., Bloomington, MN. Univ. Minnesota Extension Service, St. Paul, MN.
3. 6 exert distinct effects on homocysteine, serine, and methionine kinetics. Am. J. Physiol. Endocrinol. Metab. 281:E1182-E1190.
4. Emmert, J. L., T. A. Garrow, and D. H. Baker. 1996. Hepatic betaine-homocysteine methyltransferase activity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine. J. Nutr. 126:2050-2058.
5. Finkelstein, J. D., B. J. Harris, J. J. Martin, and W. E. Kyle. 1982. Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochem. Biophys. Res. Commun. 108:344-348.
6. Finkelstein, J. D., W. E. Kyle, and B. J. Harris. 1971. Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue. Arch. Biochem. Biophys. 146:84-92.
7. Finkelstein, J. D., and J. J. Martin. 1984. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J. Biol. Chem. 259:9508-9513.
8. Frontiera, M. S., S. P. Stabler, J. F. Kolhouse, and R. H. Allen. 1994. Regulation of methionine metabolism: Effects of nitrous oxide and excess dietary methionine. J. Nutr. Biochem. 5:28-38.
9. 3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism. Am. J. Clin. Nutr. 72:1535-1541.
10. Mudd, S. H., J. D. Finkelstein, F. Irreverre, and L. Laster. 1965. Transsulfuration in mammals: Microassays and tissue distributions of three enzyme of the pathway. J. Biol. Chem. 240:4382-4392.
11. 12 metabolism: Effects on sulfur amino acid metabolism. Biochem. Med. 4:193-214.
12. National Research Council. 1994. Nutrient Requirements of Poultry. 9th rev. ed. Natl. Acad. Press, Washington, DC.
13. Park, E. I., and T. A. Garrow. 1999. Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J. Biol. Chem. 274:7816-7824.
14. Park, E. I., M. S. Renduchintala, and T. A. Garrow. 1997. Diet-induced changes in hepatic betaine-homocysteine methyltransferase activity are mediated by changes in the steady-state level of its mRNA. J. Nutr. Biochem. 8:541-545.
15. Pesti, G. M., A. E. Harper, and M. L. Sunde. 1980. Choline/methionine nutrition of starting broiler chicks. Three models for estimating the choline requirement with economic considerations. Poult. Sci. 59:1073-1081.
16. Quillin, E. C., G. F. Combs, R. D. Creek, and G. L. Romoser. 1961. Effect of choline on the methionine requirements of broiler chickens. Poult. Sci. 40:639-645.
17. SAS Institute. 2004. SAS/STAT User's Guide: Statistics. Version 9.1 ed. SAS Inst., Inc., Cary, NC.
18. Saunderson, L., and J. Mackinlay. 1990. Changes in body-weight, composition, and hepatic enzyme activities in response to dietary methionine, betaine and choline levels in growing chicks. Br. J. Nutr. 63:339-349.
19. Stipanuk, M. H. 2004. Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine. Ann. Rev. Nutr. 24:539-577.
20. 13C]methionine. Am. J. Physiol. 255:E322-E331.
21. 13C]methionine. Am. J. Clin. Nutr. 54:386-394.
22. van Guldener, C., M. J. F. M. Janssen, K. de Meer, A. J. M. Donker, and C. D. A. Stehouwer. 1999. Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients. J. Intern. Med. 245:175-183.
23. Yamamoto, N., T. Tanaka, and T. Noguchi. 1995. Effect of cysteine on expression of cystathionine β-synthase in the rat liver. J. Nutr. Sci. Vitaminol. 41:197-205.