Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-X

Circulation

Volumn 113, Issue 13, 2006, Pages 1702-1707

  Zweers, Manon C ^a   Peeters, Anita C T M ^b   Graafsma, Sietze ^c   Kranendonk, Steef ^c   Van Der Vliet, J Adam ^b   Den Heijer, Martin ^b   Schalkwijk, Joost ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c CPRLab   (Netherlands)

Author keywords

Aneurysm; Collagen; Extracellular matrix; Pathology; Risk factors

Indexed keywords

SCLEROPROTEIN; TENASCIN; TENASCIN X; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; ADULT; AGED; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RISK FACTOR; ABDOMINAL AORTA; AORTA; BLOOD; CASE CONTROL STUDY; FLUORESCENT ANTIBODY TECHNIQUE; IN VITRO STUDY; METABOLISM; MIDDLE AGED; OSMOLARITY; TISSUE DISTRIBUTION;

AGED; AGED, 80 AND OVER; AORTA; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; TENASCIN; TISSUE DISTRIBUTION;

EID: 33645778517     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.104.513820     Document Type: Article

References (30)

1. van der Vliet JA, Boll AP. Abdominal aortic aneurysm. Lancet. 1997;349:863-866.
2. Grange JJ, Davis V, Baxter BT. Pathogenesis of abdominal aortic aneurysm: an update and look toward the future. Cardiovasc Surg. 1997;5:256-265.
3. Macsweeney ST, Powell JT, Greenhalgh RM. Pathogenesis of abdominal aortic aneurysm. Br J Surg. 1994;81:935-941.
4. Marian AJ. On genetics, inflammation, and abdominal aortic aneurysm: can single nucleotide polymorphisms predict the outcome? Circulation. 2001;103:2222-2224.
5. Curci JA, Liao S, Huffman MD, Shapiro SD, Thompson RW. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J Clin Invest. 1998;102:1900-1910.
6. Thompson RW, Holmes DR, Mertens RA, Liao S, Botney MD, Mecham RP, Welgus HG, Parks WC. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms: an elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest. 1995;96:318-326.
7. Tamarina NA, McMillan WD, Shively VP, Pearce WH. Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Surgery. 1997;122:264-271.
8. Goodall S, Crowther M, Hemingway DM, Bell PR, Thompson MM. Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms. Circulation. 2001;104:304-309.
9. Rizzo RJ, McCarthy WJ, Dixit SN, Lilly MP, Shively VP, Flinn WR, Yao JS. Collagen types and matrix protein content in human abdominal aortic aneurysms. J Vasc Surg. 1989;10:365-373.
10. Campa JS, Greenhalgh RM, Powell JT. Elastin degradation in abdominal aortic aneurysms. Atherosclerosis. 1987;65:13-21.
11. Ghorpade A, Baxter BT. Biochemistry and molecular regulation of matrix macromolecules in abdominal aortic aneurysms. Ann N Y Acad Sci. 1996;800:138-150.
12. Dobrin PB, Baker WH, Gley WC. Elastolytic and collagenolytic studies of arteries: implications for the mechanical properties of aneurysms. Arch Surg. 1984;119:405-409.
13. Towbin JA, Casey B, Belmont J. The molecular basis of vascular disorders. Am J Hum Genet. 1999;64:678-684.
14. Matsumoto K, Saga Y, Ikemura T, Sakakura T, Chiquet ER. The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C. J Cell Biol. 1994;125:483-493.
15. Burch GH, Bedolli MA, McDonough S, Rosenthal SM, Bristow J. Embryonic expression of tenascin-X suggests a role in limb, muscle, and heart development. Dev Dyn. 1995;203:491-504.
16. Schalkwijk J, Zweers MC, Steijlen PM, Dean WB, Taylor G, Van Vlijmen IM, van Haren B, Miller WL, Bristow J. A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency. N Engl J Med. 2001;345:1167-1175.
17. Zweers MC, Bristow J, Steijlen PM, Dean WB, Hamel BC, Otero M, Kucharekova M, Boezeman JB, Schalkwijk J. Haploinsufficiency of TNXB is associated with hypermobility type of Ehlers-Danlos syndrome. Am J Hum Genet. 2003;73:214-217.
18. Zweers MC, Vlijmen-Willems IM, Van Kuppevelt TH, Mecham RP, Steijlen PM, Bristow J, Schalkwijk J. Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. J Invest Dermatol. 2004;122:885-891.
19. Maraha B, den Heijer M, Wullink M, van der ZA, Bergmans A, Verbakel H, Kerver M, Graafsma S, Kranendonk S, Peeters M. Detection of Chlamydia pneumoniae DNA in buffy-coat samples of patients with abdominal aortic aneurysm. Eur J Clin Microbiol Infect Dis. 2001;20:111-116.
20. Leng GC, Fowkes FG. The Edinburgh Claudication Questionnaire: an improved version of the WHO/Rose Questionnaire for use in epidemiological surveys. J Clin Epidemiol. 1992;45:1101-1109.
21. Bristow J, Tee MK, Gitelman SE, Mellon SH, Miller WL. Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. J Cell Biol. 1993;122:265-278.
22. Peeters ACTM, Kucharekova M, Timmermans J, van den Berkmortel FWPJ, Boers GH, Novakova IRO, Egging D, den Heijer M, Schalkwijk J. A clinical and cardiovascular survey of Ehlers-Danlos syndrome palients with complete deficiency of tenascin-X. Neth J Med. 2004;62:23-25.
23. Singh K, Bonaa KH, Jacobsen BK, Bjork L, Solberg S. Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study: the Tromso Study. Am J Epidemiol. 2001;154:236-244.
24. Ailawadi G, Eliason JL, Upchurch GR Jr. Current concepts in the pathogenesis of abdominal aortic aneurysm. J Vasc Surg. 2003;38:584-588.
25. Yajima N, Masuda M, Miyazaki M, Nakajima N, Chien S, Shyy JY. Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J Vasc Surg. 2002;36:379-385.
26. Baxter BT, Davis VA, Minion DJ, Wang YP, Lynch TG, McManus BM. Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments. J Vasc Surg. 1994;19:797-802.
27. Mao JR, Taylor G, Dean WB, Wagner DR, Afzal V, Lotz JC, Rubin EM, Bristow J. Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition. Nat Genet. 2002;30:421-425.
28. Ward AS. Aortic aneurysmal disease: a generalized dilating diathesis. Arch Surg. 1992;127:990-991.
29. Mao JR, Bristow J. The Ehlers-Danlos syndrome: on beyond collagens. J Clin Invest. 2001;107:1063-1069.
30. Minamitani T, Ikuta T, Saito Y, Takebe G, Sato M, Sawa H, Nishimura T, Nakamura F, Takahashi K, Ariga H, Matsumoto K. Modulation of collagen fibrillogenesis by tenascin-X and type VI collagen. Exp Cell Res. 2004;298:305-315.