A sustained release dosage form of acyclovir for buccal application: An experimental study in dogs

Journal of Drug Targeting

Volumn 14, Issue 1, 2006, Pages 35-44

  Deǧim, Tuncer ^a   Eǧlen, Bilgen ^a   Ocak, Ömer ^b  

^a GAZI UNIVERSITY   (Turkey)

^b Nobel Drug Company   (Turkey)

Author keywords

Acyclovir; Buccal application; In vitro in vivo correlation; Pharmacokinetic analysis; Simulation

Indexed keywords

ACICLOVIR; HERNOVIR; OCTANOL; SALIVA SUBSTITUTE; VIROSIL; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEEK MUCOSA; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG PENETRATION; DRUG SOLUBILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL; STOMACH JUICE; SUSTAINED RELEASE FORMULATION; SYSTEMIC THERAPY; TABLET FORMULATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; ELECTROCHEMISTRY; ELLAGIC ACID; FLUORESCENT DYES; FREE RADICAL SCAVENGERS; LACTIC ACID; MALE; NANOSTRUCTURES; PARTICLE SIZE; PERMEABILITY; PICRATES; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SOLUBILITY;

EID: 33645763218     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860600566548     Document Type: Article

References (26)

1. Agabeyoglu, IT. (1984) Un programme dans le langue basique de microcomputer pour la determination des donnes de dissolution XVIII'eme Semaine Medicale Balkanique Resumes II, 327. 30 Aout-4 Septembre, Istanbul
2. Bangaru, RA and Bansal, YK and Rao, AR and Gandhi, TP. (2000) Rapid, simple and sensitive high-performance liquid chromatographic method for detection and determination of acyclovir in human plasma and its use in bioavailability studies J Chromatogr B Biomed Sci Appl, 739, pp. 231-237.
3. Collins, LM and Dawes, C. (1987) The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa J Dent Res, 66, pp. 1300-1302.
4. Degim, T and Pugh, WJ and Hadgraft, J. (1998) Skin permeability data: Anomalous results Int J Pharm, 170, pp. 129-133.
5. Degim, IT and Uslu, A and Hadgraft, J and Atay, T and Akay, C and Cevheroglu, S. (1999) The effects of azone and capsaicin on the permeation of naproxen through human skin Int J Pharm, 179, pp. 21-25.
6. Degim T. 1996. Physicochemical determinants of skin penetration. pHD thesis, University of Wales College of Cardiff, The Welsh School of Pharmacy, UK.
7. Degim, T and Degim, Z and Bodur, H. (1997) A comparison of local anaesthetic effect of different cream formulations using in vivo and in vitro tests Pedodontics, pp. 49. 10th congress issue
8. Eglen-Balaban B. 2001. An investigation on the new buccaly applicable acyclovir tablet formulations. Master degree thesis, Gazi University, Department of Pharmaceutical Technology, Ankara, Turkey.
9. Fyfe, JA and Keller, PM and Furman, PA and Miller, RL and Elion, GB. (1978) Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compounds J Biol Chem, 253, pp. 8721-8727.
10. Hayden, FG.(1995) Antiviral drugs. In Principles and practice of infectious Deseases. UK: Churchill Livingston Press.
11. I Think Strategy Software, Version 6.0 for Windows., High performance Systems, Inc. 45 Lyme Road, Suite 300, Honover, NH 03755.
12. Karasny, HC and De Miranda, P and Blum, MR and Elion, GB. (1981) Pharmacokinetics and bioavailability of acyclovir in the dog J Pharmacol Exp Ther, 216, pp. 281-288.
13. Lasmar, UT and Manger, J. (1994) Investigation into the potential iontophoresis facilitated transdermal delivery of acyclovir Int J Pharm, 111, pp. 73-82.
14. Meyer, J and Gerson, SJ. (1964) A comparison of human palatal and buccal mucosa Peridontics, 2, pp. 284-291.
15. Mindel, A and Adler, MW and Sutherland, S and Fiddian, AP. (1982) Intravenous acyclovir treatment for primary genital herpes Lancet, 1, pp. 697-700.
16. Purves RD, Minim Rel. 2.02, University of Otago, Po Box 913, Dunedin, New Zeland.
17. Rathbone, MJ and Hadgraft, J. (1991) Absorption of drugs from the human oral cavity Int J Pharm, 74, pp. 9-24.
18. Şenel, S and Hoogstraate, AJ and Spies, F and Verhoef, JC and Junginger, HE and Boddé, HE 1996 Visualization of enhancing effects of bile salts on buccal penetration Eur J Morphol, 31, pp. 35-41.
19. Tveit, AB and Lindh, ULF. (1980) Floride uptake in animal and dentin surface exposed to a floride containing amalgam in vitro a proton microprobe analiz Acta Odontol Scand, 38, pp. 279-283.
20. Wagner, GJ.(1979) Linear pharmacokinetic models. In Fundamentals of clinical pharmacokinetics. (pp. 57-127). Illinois, Hamilton: Drug Intelligence Publications Inc.
21. Wagstaff, AJ and Faulds, D and Goa, KL. (1994) Acyclovir: A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy Drugs, 47, pp. 153-205.
22. Washington, C and Washington, N and Wilson, C.(1990) Pharmacokinetic modelling using Stella on the apple machintosh. In. UK: Ellis Horwood Limited. Market Cross House Cooper Street, Chichester, West Sussex, PO19 1 EB
23. Welling, PG and Dobrinska, MR.(1978) Multiple dosing of sustained release systems. In Sustained and controlled release drug delivery systems. (pp. 632-715). New York: Marcel and Dekker Inc. and Basel.
24. Yamaoka, K and Nakagawa, T and Uno, T. (1978) Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations J Pharmacokinet Biopharm, 6, pp. 165-175.
25. Yetkin, G and Çelebi, N and Agabeyoglu, I and Gökçora, N. (1999) The effect of dimethyl -β- cyclodextrin and sodium taurocholate on the nasal bioavailability of salmon calcitonin in rabbits STP Pharma Sci, 9, pp. 249-252.
26. Yuen, KH and Peh, KK and Billa, N and Chan, KL and Toh, WT. (1998) Bioavailability and pharmacokinetics of acylovir tablet preparation Drug Dev Ind Pharm, 24, pp. 193-196.