Interleukin 10.G microsatellite in the promoter region of the Interleukin-10 gene in severe sepsis

Chinese Medical Journal

Volumn 119, Issue 3, 2006, Pages 197-201

  Shu, Qiang ^a   Shi, Chang Chun ^b   Zhang, Xiang Hong ^a   Shi, Zhuo ^a   Shi, Shan Shan ^a   Fang, Xiang Ming ^c   Chen, Qi Xing ^c   Stuber, Frank ^a,d  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Jinhua People's Hospital   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

Interleukin 10; Outcome; Polymorphism; Sepsis; Susceptibility

Indexed keywords

INTERLEUKIN 10; POLYACRYLAMIDE GEL; IL10 PROTEIN, HUMAN; MICROSATELLITE DNA;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; DISEASE SEVERITY; FATALITY; FEMALE; FLUORESCENCE ANALYSIS; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PROMOTER REGION; SEPSIS; SILVER STAINING; SURVIVAL; UNIVERSITY HOSPITAL; GENETIC PREDISPOSITION; GENETICS;

FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-10; MALE; MICROSATELLITE REPEATS; PROMOTER REGIONS (GENETICS); SEPSIS;

EID: 33645747450     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200602010-00004     Document Type: Article

References (20)

1. Oberholzer A, Oberholzer C, Moldawer LL. Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential role as an anti-inflammatory drug. Crit Care Med 2002;30: S58-S63.
2. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31: 1250-1256.
3. O'Garra A, Vieira P. Regulatory T cells and mechanisms of immune system control. Nat Med 2004; 10: 801-805.
4. Wunder C, Eichelbronner O, Roewer N. Are IL-6, IL-10 and PCT plasma concentrations reliable for outcome prediction in severe sepsis? A comparison with APACHE III and SAPS II. Inflamm Res 2004; 53: 158-163.
5. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24:1-8.
6. Westendorp RG, Langermans JA, Huizinga TW, Verweij CL, Sturk A. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997; 349: 170-173.
7. Theofilopoulos AN. The basis of autoimmunity: Part II. Genetic predisposition. Immunol Today 1995; 16: 150-159.
8. Imahara SD, O'Keefe GE. Genetic determinants of the inflammatory response. Curr Opin Crit Care 2004; 10: 318-324.
9. D'lfonso S, Giordano M, Mellai M, Lanceni M, Barizzone N, Marchini M, et al. Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region. Genes Immun 2002; 3:454-463.
10. Eskdale J, Kube D, Tesch H, Gallagher G. Mapping of the human IL10 gene and further characterization of the 5 flanking sequence. Immunogenetics 1997; 46: 120-128.
11. Eskdale J, Gallagher G. A polymorphic dinucleotide repeat in the human IL-10 promoter. Immunogenetics 1995; 42:444-445.
12. Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee: American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapy in sepsis. Crit Care Med 1992; 20: 864-874.
13. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A laboratory manual, 2nd ed. New York: Cold Spring Harbor Laboratory Press; 1989: 14-21.
14. Budowle B, Chakraborty R, Giusti AM, Eisenberg AJ, Allen RC. Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE. Am J Human Gene 1991; 48:137-144.
15. Sham PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 1995; 59:97-105.
16. 1, clones. J Exp Med 1989;170:2081-2095.
17. Mormann M, Rieth H, Hua TD, Assohou C, Roupelieva M, Hu SL, et al. Mosaics of gene variations in the interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used. Genes Immun 2004; 5:246-255.
18. Lowe PR, Galley HF, Abdel-Fattah A, Webster NR. Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients. Crit Care Med 2003; 31:34-38.
19. Parkes M, Satsangi J, Jewell D. Contribution of the IL-2 and IL-10 genes to inflammatory bowel disease (IBD) susceptibility. Clin Exp Immunol 1998; 113: 28-32.
20. Remick DG, Garg SJ, Newcomb DE, Wollenberg G, Huie TK, Bolgos GL. Exogenous interleukin-10 fails to decrease the mortality or morbidity of sepsis. Crit Care Med 1998; 26:895-904.