Oxygen enhances lethal effect of high-intensity, ultrashort electrical pulses

Bioelectromagnetics

Volumn 27, Issue 3, 2006, Pages 221-225

  Walker III, Kerfoot ^a   Pakhomova, Olga N ^b   Kolb, Juergen ^c   Schoenbach, Karl S ^c   Stuck, Bruce E ^a   Murphy, Michael R ^d   Pakhomov, Andrei G ^b,c,e  

^a USAF   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c OLD DOMINION UNIVERSITY   (United States)

^d AIR FORCE RESEARCH LABORATORY   (United States)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Cytotoxicity; Nanosecond pulses; Radiomodification

Indexed keywords

CELLS; CYTOTOXICITY; IONIZING RADIATION; MAMMALS;

AMBIENT OXYGEN; CELL SURVIVAL; HIGH INTENSITY; HIGH-VOLTAGES; JURKAT CELL; LETHAL EFFECTS; MAMMALIAN CELLS; NANOSECOND PULSE; RADIOMODIFICATION; ULTRASHORT ELECTRICAL PULSE;

OXYGEN;

NITROGEN; OXYGEN;

ARTICLE; CELL DAMAGE; CELL HYPOXIA; CELL KILLING; CELL STRAIN U937; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; ELECTRIC FIELD; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; IONIZING RADIATION; LETHALITY; LEUKEMIA CELL LINE; MAMMAL CELL; OXYGEN SATURATION; PRIORITY JOURNAL; RADIATION EXPOSURE;

MAMMALIA;

EID: 33645746127     PISSN: 01978462     EISSN: 1521186X     Source Type: Journal    
DOI: 10.1002/bem.20200     Document Type: Article

References (18)

1. Beebe SJ, Fox PM, Rec LJ, Somers K, Stark RH, Schoenbach KH. 2002. Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: Apoptosis induction and tumor growth inhibition. IEEE Trans. Plasma Sci 30(1):286-292.
2. Beebe SJ, Fox PM, Rec LJ, Willis LK, Schoenbach KH. 2003. Nanosecond, high-intensity pulsed electric fields induce apoptosis in human cells. FASEB J 17(11):1493-1495.
3. Chadwick KH, Leenhouts HP. 1981. The molecular theory of radiation biology. Berlin-Heidelberg-New York: Springer-Verlag.
4. Chou CK, Guy AW, Galambos R. 1982. Auditory perception of radio-frequency electromagnetic fields. J Acoust Soc Am 71(6):1321-1334.
5. Deng J, Stark RH, Schoenbach KH. 2000. A nanosecond pulse generator for intracellular electromanipulation. In Conf. Record, 2000 Twenty-Fourth Intern. Power Modulator Symp. (Norfolk, VA, 2000), pp 47-50.
6. Hall EJ. 2000. Radiobiology for the radiologist, 5th ed. Philadelphia: Lippincott.
7. Howard-Flanders P. 1960. Effect of oxygen on the radiosensitivity of bacteriophage in the presence of sulphydryl compounds. Nature 186:485-487.
8. Kolb JF, Kono S, Schoenbach KH. 2005. Nanosecond pulsed electric field generators for the study of subcellular effects. Bioelectromagnetics [DOI: 10.1002/bem.20185].
9. Kroemer G, Reed JC. 2000. Mitochondrial control of cell death. Nat Med 6:513-519.
10. Lin JC. 1978. Microwave auditory effects and applications. Springfield: Charles C. Thomas.
11. Muller KJ, Sukhorukov VL, Zimmermann U. 2001. Reversible electropermeabilization of mammalian cells by high-intensity, ultra-short pulses of submicrosecond duration. J Membrane Biol 184:161-170.
12. Nias AHW. 1998. An introduction to radiobiology, 2nd ed. Chichester: Wiley.
13. Pakhomov AG, Phinney A, Ashmore J, Walker K, Kolb J, Kono S, Schoenbach KS, Murphy MR. 2004. Characterization of the cytotoxic effect of high-intensity, 10-ns duration electrical pulses. IEEE Trans Plasma Sci 32(4):1579-1585.
14. Proskuryakov SA, Konoplyannikov AG, Gabai VL. 2003. Necrosis: A specific form of programmed cell death. Experim Cell Research 283:1-16.
15. Quintiliani M. 1979. Modification of radiation sensitivity: The oxygen effect. Int J Radiat Oncol Biol Phys 5(7):1069-1076.
16. Quintiliani M. 1986. The oxygen effect in radiation inactivation of DNA and enzymes. Int J Radiat Biol Relat Stud Phys Chem Med 50(4):573-594.
17. Schoenbach KH, Stark RH, Deng J, Aly RES. 2000. Biological/medical pulsed electric field treatments. In Conf. Record, 2000, 24th Intern. Power Modulator Symp. (Norfolk, VA, 2000), pp 42-46.
18. Schoenbach KH, Katsuki S, Stark RH, Buesher ES, Beebe SJ. 2002. Bioelectrics-New applications for pulsed power technology. IEEE Trans Plasma Sci 30(1):293-300.