Canine ACL fibroblast integrin expression and cell alignment in response to cyclic tensile strain in three-dimensional collagen gels

Journal of Orthopaedic Research

Volumn 24, Issue 3, 2006, Pages 481-490

  Henshaw, D Ross ^a   Attia, Erik ^a   Bhargava, Madhu ^a   Hannafin, Jo A ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

ACL; Canine; Fibroblast; Integrin; Strain; Tissue engineering

Indexed keywords

ALPHA5 INTEGRIN; BETA1 INTEGRIN; CELL SURFACE PROTEIN; COLLAGEN FIBRIL; COLLAGEN GEL; INTEGRIN; COLLAGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; CELL CULTURE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOG; EXTRACELLULAR MATRIX; FIBROBLAST; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; FLUORESCENCE POLARIZATION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIGAMENT SURGERY; MECHANICAL STRESS; MECHANOTRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; TISSUE ENGINEERING; ANIMAL; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; HYDROGEL; METABOLISM; METHODOLOGY; TENSILE STRENGTH;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; DOGS; FIBROBLASTS; HYDROGELS; INTEGRINS; MECHANOTRANSDUCTION, CELLULAR; STRESS, MECHANICAL; TENSILE STRENGTH; TISSUE ENGINEERING;

EID: 33645734508     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20050     Document Type: Article

References (26)

1. National Center for Health Statistics DftNHCS. 1996. Ambulatory and inpatient procedures in the United States, 1996. Vital Health Stat 139:1-119.
2. Kartus J, Movin T, Karlsson J. 2001. Donor-site morbidity and anterior knee problems after anterior cruciate ligament reconstruction using autografts. Arthroscopy 17:971-980.
3. Tashiro T, Kurosawa H, Kawakami A, et al. 2003. Influence of medial hamstring tendon harvest on knee flexor strength after anterior cruciate ligament reconstruction. A detailed evaluation with comparison of single- and double-tendon harvest. Am J Sports Med 31:522-529.
4. Strickland SM, MacGillivray JD, Warren RF. 2003. Anterior cruciate ligament reconstruction with allograft tendons. Orthop Clin North Am 34:41-47.
5. Boorman RS, Shrive NG, Frank CB. 1998. Immobilization increases the vulnerability of rabbit medial collateral ligament autografts to creep. J Orthop Res 16:682-689.
6. Newton PO, Woo SL, MacKenna DA, et al. 1995. Immobilization of the knee joint alters the mechanical and ultrastructural properties of the rabbit anterior cruciate ligament. J Orthop Res 13:191-200.
7. Urschel JD, Scott PG, Williams HT. 1988. The effect of mechanical stress on soft and hard tissue repair; a review. Br J Plast Surg 41:182-186.
8. Woo SL, Gomez MA, Sites TJ, et al. 1987. The biomechanical and morphological changes in the medial collateral ligament of the rabbit after immobilization and remobilization. J Bone Joint Surg Am 69:1200-1211.
9. Murray MM, Spector M. 1999. Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. J Orthop Res 17: 18-27.
10. Amiel D, Billings E Jr, Harwood FL. 1990. Collagenase activity in anterior cruciate ligament: protective role of the synovial sheath. J Appl Physiol 69:902-906.
11. Amiel D, Ishizue KK, Harwood FL, et al. 1989. Injury of the anterior cruciate ligament: the role of collagenase in ligament degeneration. J Orthop Res 7:486-493.
12. Banes AJ, Tsuzaki M, Yamamoto J, et al. 1995. Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals. Biochem Cell Biol 73:349-365.
13. Bolcato-Bellemin AL, Elkaim R, Abehsera A, et al. 2000. Expression of mRNAs encoding for alpha and beta integrin subunits, MMPS, and TIMPs in stretched human periodontal ligament and gingival fibroblasts. J Dent Res 79:1712-1716.
14. Palejwala S, Stein DE, Weiss G, et al. 2001. Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway. Endocrinology 142:3405-3413.
15. Parsons M, Kessler E, Laurent GJ, et al. 1999. Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen C-proteinase. Exp Cell Res 252:319-331.
16. Attia EA, Bhargavva M, Hannafin JA. 2004. The effect of strain on collagen synthesis by ACL fibroblasts in vitro. In: International Symposium of Ligament and Tendons Annual Meeting, San Francisco, CA.
17. Clark EA, Brugge JS. 1995. Integrins and signal transduction pathways: the road taken. Science 268:233-239.
18. Juliano RL, Haskill S. 1993. Signal transduction from the extracellular matrix. J Cell Biol 120:577-585.
19. Sung KL, Whittemore DE, Yang L, et al. 1996. Signal pathways and ligament cell adhesiveness. J Orthop Res 14:729-735.
20. Wang N, Butler JP, Ingber DE. 1993. Mechano-transduction across the cell surface and through the cytoskeleton. Science 260:1124-1127.
21. Gesink DS, Pacheco HO, Kuiper SD, et al. 1992. Immunohistochemical localization of beta 1-integrins in anterior cruciate and medial collateral ligaments of human and rabbit. J Orthop Res 10: 596-599.
22. Schreck PJ, Kitabayashi LR, Amiel D, et al. 1995. Integrin display increases in the wounded rabbit medial collateral ligament but not the wounded anterior cruciate ligament. J Orthop Res 13:174-183.
23. Attia EA, Bhargava M, Hannafin JA. 2004. Effect of cyclic tensile strain on ACL fibroblast proliferation integrin expression and F-actin alignment in 3D collagen gels. In: Orthopaedic Research Society Annual Meeting, San Francisco, CA.
24. Bhargava MM, Beavis AJ, Edberg JC, et al. 1999. Differential expression of integrin subunits in canine knee ligament fibroblasts. J Orthop Res 17:748-754.
25. Gotwals PJ, Chi-Rosso G, Lindner V, et al. 1996. The alpha1beta1 integrin is expressed during neointima formation in rat arteries and mediates collagen matrix reorganization. J Clin Invest 97: 2469-2477.
26. Grinnell F. 2003. Fibroblast biology in three dimensional collagen matrices. Trends Cell Biol 13:264-269.