Reversible acute methotrexate leukoencephalopathy: Atypical brain MR imaging features

Pediatric Radiology

Volumn 36, Issue 3, 2006, Pages 205-212

  Ziereisen, France ^a   Dan, Bernard ^a   Azzi, Nadira ^a   Ferster, Alina ^a   Damry, Nash ^a   Christophe, Catherine ^a  

^a HOP UNIV DES ENFANTS REINE FABIOLA   (Belgium)

Author keywords

Brain; Children; Leukoencephalopathy; Methotrexate; Treatment complication

Indexed keywords

ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; FOLINIC ACID; MERCAPTOPURINE; METHOTREXATE; PREDNISOLONE; STEROID; TIOGUANINE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE TOXICITY; ARTICLE; BRAIN CORTEX; CANCER RELAPSE; CEREBELLUM CORTEX; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; DRUG MEGADOSE; HUMAN; IMAGE ANALYSIS; LEUKOENCEPHALOPATHY; MEDICAL DOCUMENTATION; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHODGKIN LYMPHOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RETROSPECTIVE STUDY; THALAMUS; WHITE MATTER;

ACUTE DISEASE; ADOLESCENT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN DISEASES; CHILD; CHILD, PRESCHOOL; CONTRAST MEDIA; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LYMPHOMA, NON-HODGKIN; MAGNETIC RESONANCE IMAGING; MALE; METHOTREXATE; RETROSPECTIVE STUDIES;

EID: 33645734491     PISSN: 03010449     EISSN: 14321998     Source Type: Journal    
DOI: 10.1007/s00247-005-0015-z     Document Type: Article

References (26)

1. Abromowitch M, Ochs J, Pui CH, et al (1988) High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X. Med Pediatr Oncol 16:297-303
2. Keime-Guibert F, Napolitano M, Delattre JY (1998) Neurological complications of radiotherapy and chemotherapy. J Neurol 245:695-708
3. Yim YS, Mahoney DH Jr, Oshman DG (1991) Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia. Cancer 67:2058-2061
4. Paakko E, Harila-Saari A, Vanionpaa L, et al (2000) White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: Correlation with neuropsychological findings. Med Pediatr Oncol 35:456-461
5. Copeland DR (1992) Neuropsychological and psychosocial effects of childhood leukemia and its treatment. Cancer J Clin 42:283-295
6. Paakko E, Vainionpaa L, Lanning M, et al (1992) White matter changes in children treated for acute lymphoblastic leukemia. Cancer 70:2728-2733
7. Paakko E, Vainionpaa L, Pyhtinen J, et al (1996) Minor changes on cranial MRI during treatment in children with acute lymphoblastic leukaemia. Neuroradiology 38:264-268
8. Asato R, Akiyama Y, Ito M, et al (1992) Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate. Cancer 70:1997-2004
9. Shuper A, Stark B, Kornreich L, et al (2000) Methotrexate treatment protocols and the central nervous system: Significant cure with significant neurotoxicity. J Child Neurol 15:573-580
10. Gay CT, Bodensteiner JB, Nitschke R, et al (1989) Reversible treatment-related leukoencephalopathy. J Child Neurol 4:208-213
11. Lajtha A, Toth J, Fujimoto K, et al (1977) Turnover of myelin proteins in mouse brain in vivo. Biochem J 164:323-329
12. Smith ME, Eng LF (1965) The turnover of the lipid components of myelin. J Am Oil Chem Soc 42:1013-1018
13. Clark AW, Cohen SR, Nissenblatt MJ, et al (1982) Paraplegia following intrathecal chemotherapy: Neuropathologic findings and elevation of myelin basic protein. Cancer 50:42-47
14. Surtees R, Clelland J, Hann I (1998) Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies. J Clin Oncol 16:1505-1511
15. Lee CC, Surtees R, Duchen LW (1992) Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase. Brain 115:935-955
16. Refsum H, Christensen B, Djurhuus R, et al (1991) Interaction between methotrexate, 'rescue' agents and cell proliferation as modulators of homocysteine export from cells in culture. J Pharmacol Exp Ther 258:559-566
17. Quinn CT, Griener JC, Bottiglieri T, et al (1997) Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J Clin Oncol 15:2800-2806
18. Quinn CT, Kamen BA (1996) A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities. J Investig Med 44:522-530
19. Wilson DA, Nitschke R, Bowman ME, et al (1991) Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: Correlation with neuropsychologic deficiencies. Radiology 180:205-209
20. Quinn CT, Griener JC, Bottiglieri T, et al (1998) Methotrexate, homocysteine, and seizures. J Clin Oncol 16:393-394
21. Maytal J, Grossman R, Yusuf FH, et al (1995) Prognosis and treatment of seizures in children with acute lymphoblastic leukemia. Epilepsia 36:831-836
22. Lo Nigro L, Di Cataldo A, Schiliro G (2000) Acute neurotoxicity in children with B-lineage acute lymphoblastic leukemia (B-ALL) treated with intermediate risk protocols. Med Pediatr Oncol 35:449-455
23. Borgna-Pignatti C, Battisti L, Marradi P, et al (1992) Transient neurologic disturbances in a child treated with moderate-dose methotrexate. Br J Haematol 81:448
24. Sandoval C, Kutscher M, Jayabose S, et al (2003) Neurotoxicity of intrathecal methotrexate: MR imaging findings. Am J Neuroradiol 24:1887-1890
25. Hellwig B (1993) How the myelin picture of the human cerebral cortex can be computed from cytoarchitectural data. A bridge between von Economo and Vogt. Hirnforsch J 34:387-402
26. Peters A (2002) The effects of normal aging on myelin and nerve fibers: A review. J Neurocytol 31:581-593