Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder

Psychiatric Genetics

Volumn 15, Issue 4, 2005, Pages 255-258

  Lohoff, Falk W ^a,b   Berrettini, Wade H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Association study; Bipolar disorder; Genetics; Polymorphism

Indexed keywords

LEUCINE; MELANOCORTIN 5 RECEPTOR; PHENYLALANINE; SPACER DNA; CORTICOTROPIN RECEPTOR;

ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; CASE CONTROL STUDY; CHROMOSOME 18P; CONTROLLED STUDY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; CHROMOSOME 18; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; REFERENCE VALUE; SINGLE NUCLEOTIDE POLYMORPHISM;

BIPOLAR DISORDER; CHROMOSOMES, HUMAN, PAIR 18; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CORTICOTROPIN; REFERENCE VALUES; VARIATION (GENETICS);

EID: 33645733199     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-200512000-00007     Document Type: Article

References (27)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington, District of Columbia: American Psychiatric Press.
2. Bennett P, Segurado R, Jones I, Bort S, McCandless F, Lambert D, et al. (2002). The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Mol Psychiatry 7:189-200.
3. Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberger JI Jr, et al. (1994). Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 91:5918-5921.
4. Berrettini WH, Vuoristo J, Ferraro TN, Buono RJ, Wildenauer D, Ala-Kokko L (1998). Human G(olf) gene polymorphisms and vulnerability to bipolar disorder. Psychiatr Genet 8:235-238.
5. Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1995). Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization. Cytogenet Cell Genet 68:79-81.
6. Craddock N, Jones I (1999). Genetics of bipolar disorder [review]. J Med Genet 36:585-594.
7. Dhillo WS, Small CJ, Seal LJ, Kim MS, Stanley SA, Murphy KG, et al. (2002). The hypothalamic melanocortin system stimulates the hypothalamo- pituitary-adrenal axis in vitro and in vivo in male rats. Neuroendocrinology 75:209-216.
8. Ehlert U, Gaab J, Heinrichs M (2001). Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the role of the hypothalamus-pituitary-adrenal axis [review]. Biol Psychol 57:141-152.
9. Fathi Z, Iben LG, Parker EM (1995). Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. Neurochem Res 20:107-113.
10. Gauderman WJ (2002). Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 155:478-484.
11. Haga H, Yamada R, Ohnishi Y, Nakamura Y, Tanaka T (2002). Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism. J Hum Genet 47:605-610.
12. Kathol RG, Jaeckle RS, Lopez JF, Meller WH (1989). Pathophysiology of HPA axis abnormalities in patients with major depression: an update [review]. Am J Psychiatry 146:311-317.
13. Kim MS, Small CJ, Stanley SA, Morgan DG, Seal LJ, Kong WM, et al. (2000). The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 105:1005-1011.
14. Lander ES, Schork NJ (1994). Genetic dissection of complex traits. Science 265:2037-2048.
15. NIMH Genetics Initiative Bipolar Group (1997). Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: a preliminary report. Am J Med Genet 74:227-237.
16. Nothen MM, Cichon S, Rohleder H, Hemmer S, Franzek E, Fritze J, et al. (1999). Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families. Mol Psychiatry 4:76-84.
17. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. (1994). Diagnostic Interview for Genetic Studies: rationale, unique features, and training. Arch Gen Psychiatry 51:849-859.
18. Patil N, Berno AJ, Hinds DA, Barrett WA, Doshi JM, Hacker CR, et al. (2001). Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294:1719-1723.
19. Perneger TV (1998). What's wrong with Bonferroni adjustments. BMJ 316:1236-1238.
20. Plotsky PM, Owens MJ, Nemeroff CB (1998). Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis [review]. Psychiatr Clin North Am 21:293-307.
21. Reyes GD, Esterling LE, Corona W, Ferraren D, Rollins DY, Padigaru M, et al. (2002). Map of candidate genes and STSs on 18p11.2, a bipolar disorder and schizophrenia susceptibility region. Mol Psychiatry 7:337-339.
22. Rojas K, Liang L, Johnson EI, Berrettini WH, Overhauser J (2000). Identification of candidate genes for psychiatric disorders on 18p11. Mol Psychiatry 5:389-395.
23. Spielman RS, Ewens WJ (1996). The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
24. Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C, et al. (1995). Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 57:1384-1394.
25. Swann AC, Stokes PE, Casper R, Secunda SK, Bowden CL, Berman N, et al. (1992). Hypothalamic-pituitary-adrenocortical function in mixed and pure mania. Acta Psychiatr Scand 85:270-274.
26. Yoshikawa T, Padigaru M, Karkera JD, Sharma M, Berrettini WH, Esterling LE, et al. (2000). Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2). Mol Psychiatry 5:165-171.
27. Zapata C, Carollo C, Rodriguez S (2001). Sampling variance and distribution of the D0 measure of overall gametic disequilibrium between multiallelic loci. Ann Hum Genet 65 (Pt 4):395-406.