Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: Structural MR imaging changes and apolipoprotein E genotype

American Journal of Neuroradiology

Volumn 27, Issue 2, 2006, Pages 359-362

  Van Den Boom, R ^a   Lesnick Oberstein, S A J ^a   Van Den Berg Huysmans, A A ^a   Ferrari, M D ^a   Van Buchem, M A ^a   Haan, J ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RIJNLAND HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E EPSILON4; APOLIPOPROTEIN E4; NOTCH RECEPTOR; NOTCH3 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; AUTOMATION; BRAIN INFARCTION; CADASIL; CLINICAL ARTICLE; COMPUTER PROGRAM; CORRELATION ANALYSIS; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; FEMALE; FISHER EXACT TEST; GENOTYPE; HUMAN; IMAGE ANALYSIS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; RISK FACTOR; STUDENT T TEST; WHITE MATTER; BRAIN; CHROMOSOME ABERRATION; DIFFERENTIAL DIAGNOSIS; GENETICS; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; STATISTICS;

ADULT; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BRAIN; CADASIL; CHROMOSOME ABERRATIONS; DIAGNOSIS, DIFFERENTIAL; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RECEPTORS, NOTCH; STATISTICS;

EID: 33645731583     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Joutel A, Corpechot C, Ducros A, et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996;383: 707-10
2. Dichgans M, Mayer M, Uttner I, et al. The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Ann Neurol 1998;44:731-39
3. Van den Boom R, Lesnik Oberstein SA, Ferrari MD, et al. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: MR imaging findings at different ages: 3rd-6th decades. Radiology 2003;229: 683-90
4. Mahley RW. Apolipoprotein E cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-30
5. Nathoo N, Chetty R, van Dellen JR, et al. Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E. Mol Pathol 2003;56:132-36
6. Premkumar DR, Cohen DL, Hedera P, et al. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996; 148:2083-95
7. Oberstein SA, Ferrari MD, Bakker E, et al. Diagnostic Notch3 sequence analysis in CADASIL: three new mutations in Dutch patients: Dutch CADASIL Research Group. Neurology 1999;52:1913-15
8. Haan J, Van Broeckhoven C, van Duijn CM, et al. The apolipoprotein E epsilon 4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutations. Ann Neurol 1994;36:434-37
9. Jungreis CA, Kanal E, Hirsch WL, et al. Normal perivascular spaces mimicking lacunar infarction: MR imaging. Radiology 1988;169:101-04
10. Heier LA, Bauer CJ, Schwartz L, et al. Large Virchow-Robin spaces: MR-clinical correlation. AJNR Am J Neuroradiol 1989;10:929-36
11. Song CJ, Kim JH, Kier EL, et al. MR imaging and histologic features of subinsular bright spots on T2- weighted MR images: Virchow-Robin spaces of the extreme capsule and insular cortex. Radiology 2000;214:671-77
12. Bokura H, Kobayashi S, Yamaguchi S. Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological study. J Neurol 1998;245:116-22
13. Lesnik Oberstein SA, Van den Boom R, Van Buchem MA, et al. Cerebral microbleeds in CADASIL. Neurology 2001;57:1066-70
14. Van den Boom R, Lesnik Oberstein SA, Van Duinen SG, et al. Subcortical lacunar lesions: an MR imaging finding in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Radiology 2002;224:791-96
15. Opherk C, Peters N, Herzog J, et al. Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients. Brain 2004;127:2533-39
16. Dichgans M, Filippi M, Bruning R, et al. Quantitative MRI in CADASIL: correlation with disability and cognitive performance. Neurology 1999;52: 1361-67
17. Singhal S, Bevan S, Barrick T, et al. The influence of genetic and cardiovascular risk factors on the CADASIL phenotype. Brain 2004;127:2031-38
18. Bornebroek M, Haan J, Van Duinen SG, et al. Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype. Ann Neurol 1997;41:695-98