Long-term stability of a patient-convenient 1mg/ml suspension of tacrolimus for accurate maintenance of stable therapeutic levels

Bone Marrow Transplantation

Volumn 37, Issue 8, 2006, Pages 781-784

  Elefante, A ^a   Muindi, J ^a   West, K ^a   Dunford, L ^a   Abel, S ^a   Paplham, P ^a   Brown, K ^a   Hahn, T ^a   Padmanabhan, S ^a   Battiwalla, M ^a   McCarthy Jr , Philip L ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Allogenic bone marrow transplant; Formulation; Graft versus host disease; Medication errors; Stability; Tacrolimus

Indexed keywords

CARBOXYMETHYLCELLULOSE; CARRAGEENAN; FLAVORING AGENT; GELATIN; GLYCEROL; MICROCRYSTALLINE CELLULOSE; SORBITOL; SUCROSE; TSUKUBAENOLIDE; WATER; XANTHAN;

ACCURACY; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CHILD CARE; CONCENTRATION (PARAMETERS); CONFUSION; CONTROLLED STUDY; DRUG CAPSULE; DRUG FORMULATION; DRUG STABILITY; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEDICATION ERROR; PRIORITY JOURNAL; SUSPENSION;

ADMINISTRATION, ORAL; BONE MARROW TRANSPLANTATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GRAFT VS HOST DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MODELS, STATISTICAL; SPECIMEN HANDLING; TACROLIMUS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 33645725624     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705320     Document Type: Article

References (4)

1. Goto T, Kino T, Hatanaka H, Okuhara M, Kohsaka M, Aoki H et al. FK506: historical perspectives. Transplant Proc 1991; 23: 2713-2717.
2. Prograf package insert. Fujisawa: Deerfield, IL, April 1994.
3. Jacobson PA, Johnson CE, West NJ, Foster JA. Stability of tacrolimus in an extemporaneously compounded oral liquid. Am J Health Syst Pharm 1997; 54: 178-180.
4. Taormina D, Abdallah HY, Venkataramanan R, Logue L, Burckart GJ, Ptachcinski RJ et al. Stability and sorption of FK506 in 5% dextrose injection and 0.9% sodium chloride injection in glass, polyvinyl chloride and polyolefin containers. Am J Hosp Pharm 1992; 49: 119-122.