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Volumn 3, Issue 4, 2006, Pages 170-171

EGFR mutations and molecularly targeted therapy: A new era in the treatment of lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; PLACEBO; PROTEIN TYROSINE KINASE;

EID: 33645709473     PISSN: 17434254     EISSN: 17434262     Source Type: Journal    
DOI: 10.1038/ncponc0476     Document Type: Review
Times cited : (14)

References (10)
  • 1
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • Fukuoka M et al. (2003) Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21: 2237-2246
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1
  • 2
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG et al. (2003) Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA 290: 2149-2158
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1
  • 3
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA et al. (2005) Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353: 123-132
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1
  • 4
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N et al. (2005) Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366: 1527-1537
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1
  • 5
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ et al. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129-2139
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 6
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG et al. (2004) EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304: 1497-1500
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1
  • 7
    • 20444459499 scopus 로고    scopus 로고
    • The impact of epidermal-growth-factor-receptor mutations in response to lung-cancer therapy
    • Dowell JE and Minna JD (2004) The impact of epidermal-growth-factor-receptor mutations in response to lung-cancer therapy. Nat Clin Pract Oncol 1: 2-3
    • (2004) Nat Clin Pract Oncol , vol.1 , pp. 2-3
    • Dowell, J.E.1    Minna, J.D.2
  • 8
    • 22044453790 scopus 로고    scopus 로고
    • Erlotinib in lung cancer - Molecular and clinical predictors of outcome
    • Tsao MS et al. (2005) Erlotinib in lung cancer - molecular and clinical predictors of outcome. N Engl J Med 353: 133-144
    • (2005) N Engl J Med , vol.353 , pp. 133-144
    • Tsao, M.S.1
  • 9
    • 77957957671 scopus 로고    scopus 로고
    • Molecular analysis of EGFR gene copy number, EGFR expression and Akt activation status in advanced non-small-cell lung cancer treated with gefitinib or placebo (ISEL trial)
    • [abstract #268a] 2005 November 14-18; Philadelphia
    • Hirsch FR et al. (2005) Molecular analysis of EGFR gene copy number, EGFR expression and Akt activation status in advanced non-small-cell lung cancer treated with gefitinib or placebo (ISEL trial) [abstract #268a]. In Proceedings of the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: 2005 November 14-18; Philadelphia, 124-125
    • (2005) Proceedings of the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics , pp. 124-125
    • Hirsch, F.R.1
  • 10
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F et al. (2005) Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97: 643-655
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.