Long-term enhancement of pulmonary gas exchange after high-altitude residence during maturation

Journal of Applied Physiology

Volumn 100, Issue 2, 2006, Pages 474-481

  McDonough, Paul ^a   Dane, D Merrill ^a   Hsia, Connie C W ^a   Yilmaz, Cuneyt ^a   Johnson Jr , Robert L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Canine; Chronic hypoxia; Erythrocyte volume; Exercise; Lung volume; Membrane diffusing capacity; Pulmonary capillary blood volume; Pulmonary diffusing capacity; Somatic maturation

Indexed keywords

ALTITUDE; ANIMAL EXPERIMENT; ARTICLE; CIRCULATION; CONTROLLED STUDY; DOG; ERYTHROCYTE VOLUME; EVOLUTIONARY ADAPTATION; EXERCISE; HEART OUTPUT; HEMATOCRIT; HIGH RESOLUTION COMPUTER TOMOGRAPHY; LUNG CAPILLARY PRESSURE; LUNG DIFFUSION CAPACITY; LUNG FUNCTION; LUNG GAS EXCHANGE; LUNG VOLUME; MALE; MATURATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REBREATHING; SEA LEVEL;

ACCLIMATIZATION; ALTITUDE; ANIMALS; DOGS; ERYTHROCYTE VOLUME; MALE; PHYSICAL CONDITIONING, ANIMAL; PLASMA VOLUME; PULMONARY GAS EXCHANGE; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS; RESPIRATORY SYSTEM; TIME FACTORS;

EID: 33645651594     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01069.2005     Document Type: Article

References (43)

1. American Thoracic Society Workshop Report. Mechanisms and limits of induced postnatal lung growth. Am J Respir Crit Care Med 170: 319-343, 2004.
2. Bartlett D Jr and Remmers JE. Effects of high altitude on the lungs of young rats. Respir Physiol 13: 116-125, 1971.
3. Brody JS, Lahiri S, Simpser M, Motoyama EK, and Velasquez T. Lung elasticity and airway dynamics in Peruvian natives to high altitude. J Appl Physiol 42: 245-251, 1977.
4. 2 on the growth of the pulmonary gas exchange apparatus. Chest 59: 25s-26s, 1971.
5. 2 on the growing lung, adaptation of the growing rat lung to hypoxia and hyperoxia. Respir Physiol 11: 247-264, 1971.
6. Cerny FC, Dempsey JA, and Reddan WG. Pulmonary gas exchange in non-native residents of high altitude. J Clin Invest 52: 2993-2999, 1973.
7. Dane DM, Yan X, Tamhane RM, Johnson RL Jr, Estrera AS, Hogg DC, Hogg RT, and Hsia CCW. Retinoic acid-induced alveolar cellular growth does not improve function after right pneumonectomy. J Appl Physiol 96: 1090-1096, 2004.
8. DeGraff AC Jr, Grover RF, Johnson RL Jr, Hammond JW Jr, and Miller JM. Diffusing capacity of the lung in Caucasians native to 3,100 m. J Appl Physiol 29: 71-76, 1970.
9. Droma TS, McCullough RG, McCullough RE, Zhuang JG, Cymerman A, Sun SF, Sutton JR, and Moore LG. Increased vital and total lung capacities in Tibetan compared with Han residents of Lhasa (3658 m). Am J Phys Anthropol 86: 341-351, 1991.
10. Frisancho AR. Human growth and pulmonary function of a high altitude Peruvian Quechua population. Hum Biol 41: 364-379, 1969.
11. Frisancho AR. Developmental adaptation to high altitude hypoxia. Int J Biometeorol 21: 135-146, 1977.
12. Grover RF, Johnson RL Jr, McCullough RG, McCullough RE, Hofmeister SE, Campbell WB, and Reynolds RC. Pulmonary hypertension and pulmonary vascular reactivity in beagles at high altitude. J Appl Physiol 65: 2632-2640, 1988.
13. Harrison GA, Kuchemann EF, Moore MAS, Boyce AJ, Baju T, Mourant AE, Godber MJ, Glasgow BG, Kopec AC, Tills D, and Clegg EJ. The effects of altitude variation in Ethiopian populations. Philos Trans R Soc Lond B Biol Sci 256: 147-182, 1969.
14. 2Hb in red cells of different species. Respir Physiol 7: 43-63, 1969.
15. Hsia CC, Yan X, Dane DM, and Johnson RL Jr. Density-dependent reduction of nitric oxide diffusing capacity after pneumonectomy. J Appl Physiol 94: 1926-1932, 2003.
16. Hsia CCW, Herazo LF, Ramanathan M, and Johnson RL Jr. Cardiopulmonary adaptations to pneumonectomy in dogs. IV. Membrane diffusing capacity and capillary blood volume. J Appl Physiol 77: 998-1005, 1994.
17. Hsia CCW, Herazo LF, Ramanathan M, Johnson RL Jr, and Wagner PD. Cardiopulmonary adaptations to pneumonectomy in dogs. II. Ventilation-perfusion relationships and microvascular recruitment. J Appl Physiol 74: 1299-1309, 1993.
18. Hsia CCW, Polo Carbayo JJ, Yan X, and Bellotto DJ. Enhanced alveolar growth and remodeling in guinea pigs raised at high altitude. Respir Physiol Neurobiol 147: 105-115, 2005.
19. Jibelian G, Mitchell RR, and Overland ES. Influence of hematocrit and temperature on solubility of acetylene and dimethyl ether. J Appl Physiol 51: 1357-1361, 1981.
20. Johnson CL and LaRoche G. Simulated altitude and iodine metabolism in rats. II. Effects of chronic exposure on serum and thyroid iodinated components; effects on blood fractions and some organ weights. Aerospace Med 39: 365-375, 1968.
21. Johnson RL Jr. Adventures in gas exchange. In: The Pulmonary Circulation and Gas Exchange, edited by Wagner WW Jr. and Weir EK. Armonk, NY: Futura, 1994, p. 221-234.
22. Johnson RL Jr, Cassidy SS, Grover RF, Schutte JE, and Epstein RH Functional capacities of lungs and thorax in beagles after prolonged residence at 3,100 m. J Appl Physiol 59: 1773-1782, 1985.
23. Lahiri S, DeLaney RG, Brody JS, Simpser M, Velasquez T, Motoyama EK, and Polgar C. Relative role of environmental and genetic factors in respiratory adaptation to high altitude. Nature 261: 133-135, 1976.
24. Lechner AJ and Banchero N. Lung morphometry in guinea pigs acclimated to hypoxia during growth. Respir Physiol 42: 155-169, 1980.
25. Levine BD, and Stray-Gundersen J. The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise. Adv Exp Med Biol 502: 75-88, 2001.
26. Mackintosh IC, Dormehl IC, van Gelder AL, and du Plessis M. Blood volume, heart rate, and left ventricular ejection fraction changes in dogs before and after exercise during endurance training. Am J Vet Res 44: 1960-1962, 1983.
27. Ou LC, Kim D, Layton WM Jr, and Smith RP. Splenic erythropoiesis in polycythemic response of the rat to high-altitude exposure. J Appl Physiol 48: 857-861, 1980.
28. Ravikumar P, Yilmaz C, Dane DM, Johnson RL Jr, Estrera AS, and Hsia CC. Regional lung growth following pneumonectomy assessed by computed tomography. J Appl Physiol 97: 1567-1574, 2004.
29. Remmers JE and Mithoefer JC. The carbon monoxide diffusing capacity in permanent residents at high altitudes. Respir Physiol 6: 233-244, 1969.
30. Roughton FJW and Forster RE. Relative importance of diffusion and chemical reaction rates in determining the rate of exchange of gases in the human lung, with special reference to true diffusing capacity of the pulmonary membrane and volume of blood in lung capillaries. J Appl Physiol 11: 290-302, 1957.
31. Sackner MA, Greenletch D, Heiman M, Epstein S, and Atkins N. Diffusing capacity, membrane diffusing capacity, capillary blood volume, pulmonary tissue volume and cardiac output by a rebreathing technique. Am Rev Respir Dis 111: 157-165, 1975.
32. Sackner MA, Markwell G, Atkins N, Birch SJ, and Fernandez RJ. Rebreathing techniques for pulmonary capillary blood flow and tissue volume. J Appl Physiol 49: 910-915, 1980.
33. Salazar E and Knowles JH. An analysis of pressure-volume characteristics of the lungs. J Appl Physiol 19: 97-104, 1964.
34. Sarelius IH. Plasma volume shifts during moderate exercise in splenectomized greyhounds. J Physiol 292: 391-405, 1979.
35. Schmidt W, Heinicke K, Rojas J, Manuel Gomez J, Serrato M, Mora M, Wolfarth B, Schmid A, and Keul J. Blood volume and hemoglobin mass in endurance athletes from moderate altitude. Med Sci Sports Exerc 34: 1934-1940, 2002.
36. Sekhon HS and Thurlbeck WM. Lung growth in hypobaric normoxia, normobaric hypoxia, and hypobaric hypoxia in growing rats. I. Biochemistry. J Appl Physiol 78: 124-131, 1995.
37. Sekhon HS and Thurlbeck WM. Time course of lung growth following exposure to hypobaria and/or hypoxia in rats. Respir Physiol 105: 241-252, 1996.
38. Shi X, Stevens GH, Foresman BH, Stern SA, and Raven PB. Autonomic nervous system control of the heart: endurance exercise training. Med Sci Sports Exerc 27: 1406-1413, 1995.
39. Takeda S, Hsia CCW, Wagner E, Ramanathan M, Estrera AS, and Weibel ER. Compensatory alveolar growth normalizes gas exchange function in immature dogs after pneumonectomy. J Appl Physiol 86: 1301-1310, 1999.
40. Tucker A and Horvath SM. Relationship between organ weight and blood flow in rats adapted to simulated high altitude. Aerospace Med 44: 1036-1039, 1973.
41. Vatner SF, Higgins CB, Millard RW, and Franklin D. Role of the spleen in the peripheral vascular response to severe exercise in untethered dogs. Cardiovasc Res 8: 276-282, 1974.
42. Wagner PD. Reduced maximal cardiac output at altitude - mechanisms and significance. Respir Physiol 120: 1-11, 2000.
43. Zar JH. Biostatistical Analysis. Upper Saddle River, NJ: Prentice-Hall, 1999.