Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes

European Journal of Clinical Nutrition

Volumn 60, Issue 4, 2006, Pages 529-537

  Yoshida, M ^a   Vanstone, C A ^a   Parsons, W D ^a   Zawistowski, J ^b   Jones, Peter J H ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Forbes Medi Tech Inc   (Canada)

Author keywords

Glucomannan; Glycemia; Lipids; Mild hypercholesterolemia; Plant sterols

Indexed keywords

CAMPESTANOL; CAMPESTEROL; CHOLESTEROL; LATHOSTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MANNAN; PHYTOSTEROL; PLACEBO; SITOSTANOL; SITOSTEROL;

ADULT; AGED; ARTICLE; CANADA; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERCHOLESTEROLEMIA; MALE; METEORISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OPTIMAL DRUG DOSE; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE;

ADULT; AGED; CATHARTICS; CHOLESTEROL; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; MALE; MANNANS; MIDDLE AGED; PHYTOSTEROLS;

EID: 33645651197     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602347     Document Type: Article

References (30)

1. Arvill A, Bodin L (1995). Effect of short-term ingestion of glucomannan on serum cholesterol in healthy men. Am J Clin Nutr 61, 585-589.
2. Chen HL, Shen WH, Tai TS, Liaw YP, Chen YC (2003). Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects - a randomized double-blinded trial. J Am Coll Nutr 22, 36-42.
3. Doi K (1995). Effects of konjac fiber (glucomannan) on glucose and lipids. Eur J Clin Nutr 49, S190-S197.
4. Doi K, Masuura M, Kawara A, Baba S (1979). Treatment of diabetes with glucomannan. Lancet 1, 987-988. (abstract).
5. Doi K, Nakamura T, Aoyama N, Matsuura M, Kawara A (1990). Metabolic and nutritional effects of long-term use of glucomannan in the treatment of obese diabetics. In: Oomura Y, Tarui S, Inoue S and Shimazu T (eds). Progress in Obesity Research 1990. Proceedings of the Sxith International Congress on Obesity. John Libbey: London, pp 507-514.
6. Expert panel on detection, elevation, and treatment of high blood cholesterol in adults (2001). Executive summary of the third report of the national cholesterol education (NCEP) expert panel on detection, evaluation, and treatment of high cholesterol in adults (adult treatment panel III). JAMA 285, 2486-2497.
7. Friedewald WT, Levy RI, Fredrickson DS (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of preparative ultracentrifuge. Clin Chem 18, 499-502.
8. Gylling H, Miettinen TA (1997). Cholesterol absorption, synthesis, and LDL metabolism in NIDDM. Diabetes Care 20, 90-95.
9. Gylling H, Puska P, Vartiainen E, Miettinen TA (1999). Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. J Lipid Res 40, 593-600.
10. Hallikainen MA, Sarkkinen ES, Gylling H, Erkkila AT, Uusitupa MIJ (2000). Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low fat diet. Eur J Clin Nutr 54, 715-725.
11. Huang CY, Zhang MY, Peng SS, Hong JR, Wang X, Jiang HJ et al. (1990). Effect of konjac food on blood glucose level in patients with diabetes. Biomed Environ Sci 3, 123-132.
12. Ikeda I, Tanaka K, Sugano M, Vahouny GV, Gallo LL (1988). Inhibition of cholesterol absorption in rats by plant sterols. J Lipid Res 29, 1573-1582.
13. Jones PJ, Leitch CA, Pederson RA (1993). Meal-frequency effects on plasma hormone concentrations and cholesterol synthesis in human. Am J Clin Nutr 57, 868-874.
14. Jones PJ, Reaini-Sarjaz M, Ntanios FY, Vanstone CA, Feng JY, Parsons WD (2000). Modulation of plasma lipids levels and cholesterol kinetics by phytosterol versus phytostanol esters. J Lipid Res 41, 697-705.
15. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R, Stresa Workshop Participants (2003). Efficacy and safety of plant stanols and sterols in the management of blood cholesterol. Mayo Clin Proc 78, 965-978.
16. Lakshmanan MR, Nepokroeff CM, Ness GC, Dugan RE, Porter JW (1973). Stimulation of insulin of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis activity. Biochem Biophys Res Commun 50, 704-710.
17. Matsuura M (1986). Effects of dietary fiber (glucomannan) on serum cholesterol. Jpn Soc Clin Nutr 8, 1-11.
18. Miettinen TA, Tilvis RS, Kesaniemi YA (1990). Serum plant sterol and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 131, 20-31.
19. Nissinen M, Gylling H, Vuoristo M, Miettinen TA (2002). Micellar distribution of cholesterol and phytosterols after duodenal plant sterol ester infusion. Am J Physiol Gastrointest Liver Physiol 282, G1009-G1015.
20. Ntanios FY, Jones PJ (1998). Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters. Biochim Biophys Acta 1390, 237-244.
21. Osborne AR, Pollock VV, Lagor WR, Ness GC (2004). Identification of insulin-responsive region in the HMG-CoA reductase promoter. Biochem Biophys Res Commun 318, 814-818.
22. Pollack OJ (1953). Reduction of blood cholesterol in man. Circulation 2, 702-706.
23. Scalfi L, Coltorti A, D'Arrigo E, Carandente V, Mazzacano C, Di Palo M et al. (1987). Effect of dietary fibre on postprandial thermogenesis. Int J Obes Relat Metab Disord 11, 95-99.
24. Siedel J, Hagele EO, Ziegenhorn J, Wahlefeld AW (1983). Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 29, 1075-1080.
25. Sugiuchi H, Uji Y, Okabe H, Irie T, Uekama K, Kayahara N et al. (1995). Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and sulfated alpha-cyclodextrin. Clin Chem 41, 717-723.
26. Vanstone CA, Raeini-Sarjaz M, Parsons WE, Jones PJ (2002). Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. Am J Clin Nutr 76, 1272-1278.
27. Varady KA, Ebine N, Vanstone CA, Parsons WE, Jones PJ (2004). Plant sterols and endurance training combine to favourably alter plasma lipid profiles in previously sedentary hyporcholesterolemic adults after 8 wk. Am J Clin Nutr 80, 1159-1166.
28. Vuksan V, Sievenpiper JL, Xu Z, Wong EY, Jenkins AL, Beljan-Zdravkovic U et al. (2001). Konjac-Mannan and American ginsing: Emerging alternative therapies for type 2 diabetes mellitus. J Am Coll Nutr 20, 370S-380S.
29. Vuksan V, Vidgen E, Sievenpiper JL, Brighenti F, Owen R, Josse RG et al. (2000). Beneficial effects of viscous dietary fiber from konjac-mannan in subjects with the insulin resistance syndrome. Diabetes Care 23, 9-14.
30. Weststrate JA, Meijer GW (1998). Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 52, 334-343.