A survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies

Environmental Health Perspectives

Volumn 114, Issue 4, 2006, Pages 537-541

  Peddada, Shyamal D ^a   Kissling, Grace E ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cancer bioassay; Cochran armitage trend test; Multiple pairwise comparisons; National toxicology program; Order restricted inference; Poly 3 trend test

Indexed keywords

CARCINOGEN; ISOPRENE;

ANALYTICAL ERROR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; BREAST FIBROADENOMA; CANCER INCIDENCE; CANCER SURVIVAL; CARCINOGENICITY; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPOSURE; FEMALE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; REGRESSION ANALYSIS;

ANIMALS; CARCINOGENICITY TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; NEOPLASMS, EXPERIMENTAL; NONLINEAR DYNAMICS; RATS; RATS, INBRED F344; SURVIVAL ANALYSIS;

ANIMALIA; RODENTIA;

EID: 33645645809     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8590     Document Type: Article

References (10)

1. Armitage P. 1955. Tests for linear trends in proportions and frequencies. Biometrics 11:375-386.
2. Bailer A, Portier C. 1988. Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44:417-431.
3. Bieler G, Williams R. 1993. Ratio estimates, the delta method, and quantal response tests for increased carcinogenicity. Biometrics 49:793-801.
4. 2 tests. Biometrics 10:417-451.
5. Dinse G. 1991. Constant risk differences in the analysis of animal tumorigenicity data. Biometrics 47:681-700.
6. Hwang J, Peddada S. 1994. Confidence interval estimation subject to order restrictions. Ann Stat 22:67-93.
7. NTP. 1999. Toxicology and Carcinogenesis Studies of Isoprene (CAS No. 78-79-5) in F344/N Rats (Inhalation Studies). Technical Report No. 486. Research Triangle Park, NC:National Toxicology Program.
8. Peddada S, Dinse G, Haseman J. 2005. A survival-adjusted quantal response test for comparing tumor incidence rates. Appl Stat 54:51-61.
9. Peddada S, Prescott K, Conaway M. 2001. Tests for order restrictions in binary data. Biometrics 57:1219-1227.
10. Portier CJ, Bailer AJ. 1989. Testing for increased carcinogenicity using a survival-adjusted quantal response test. Fundam Appl Toxicol 12:731-737.