Variability of antiepileptic medication taking behaviour in sudden unexplained death in epilepsy: Hair analysis at autopsy

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 77, Issue 4, 2006, Pages 481-484

  Williams, J ^b   Lawthom, C ^b   Dunstan, F D ^b   Dawson, T P ^c   Kerr, M P ^b   Wilson, J F ^b   Smith, P E M ^a,b  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c LANCASHIRE TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; ETHOSUXIMIDE; GABAPENTIN; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG HAIR LEVEL; EPILEPSY; FEMALE; HAIR ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INGESTION; LINEAR REGRESSION ANALYSIS; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; SCHOOL CHILD; SUDDEN DEATH;

ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; AUTOPSY; CAUSE OF DEATH; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEATH, SUDDEN; EPILEPSY; FEMALE; HAIR; HUMANS; MALE; MIDDLE AGED;

EID: 33645580598     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2005.067777     Document Type: Article

References (17)

1. Nashef L. Sudden unexpected death in epilepsy: terminology and definitions. Epilepsia 1997;38(suppl 11):S6-8.
2. Annegers JF. Sudden unexpected death in epilepsy: United States perspective on definitions and classifications. Epilepsia 1997;38(suppl 11):S9-12.
3. Dasheiff RM. Sudden unexplained death in epilepsy: a series from an epilepsy surgery programme and speculation on the relationship to sudden cardiac death. J Clin Neurophysiol 1991;8:216-22.
4. Walczak TS, Leppik IE, D'Amelio M, et al. Incidence and risk factors in sudden unexpected deatn in epilepsy: a prospective cohort study. Neurology 2001;56:519-25.
5. Tomson T, Skold A-C, Holingren P, et al. Post mortem changes in blood concentration of phenytoin and carbamazepine: an experimental study. Ther Drug Monit 1998;20:309-12.
6. Uematsu T. Utilisation of hair analysis for therapeutic drug monitoring. Forensic Sci Int 1993;63:201-8.
7. Saitoh MM, Uzuka RL, eds. Advances in biology of skin, Vol 9. Oxford: Pergamon Press, 1969:183-202.
8. Williams J, Patsalos PN, Mei Z, et al. Relation between dosage of carbamazepine and concentration in hair and plasma samples from a compliant in-patient epileptic population. Ther Drug Monit 2001;23:15-20.
9. Saris LA, Brekelmans GFT, van aer Linden GJ, et al. High performance liquid chromatography of carbamazepine metabolites in human hair. J Chromatogr B 1997;691:409-15.
10. Mei Z, Williams J. Simultaneous measurement of phenytoin and carbamazepine in human hair by high performance liquid chromatography. Ther Drug Monit 1997;19:92-4.
11. Williams J, Myson V, Steward S, et al. Self-discontinuation of antiepileptic medication in pregnancy: detection by hair analysis. Epilepsia 2002;44:824-31.
12. Tennis P, Cole TB, Annegers JF, et al. Cohort study of incidence of sudden unexplained death in persons with seizure disorder treated with antiepileptic drugs in Saskatchewan, Canada. Epilepsia 1995;36:29-36.
13. Nilsson L, Bergman U, Diwan V, et al. Antiepileptic drug therapy and its management in sudden unexplained death in epilepsy: a case control study. Epilepsia 2001;42:667-3.
14. Opeskin K, Burke MP, Cordner SM, et al. Comparison of antiepileptic drug levels in sudden unexpected deaths in epilepsy with deaths from other causes. Epilepsia 1999;40:1795-8.
15. Nilsson L, Farahmand BY, Persson P-G, et al. Risk factors for sudden unexpected death in epilepsy: a case-control study. Lancet 1999;353:888-93.
16. UK Department of Health. Why mothers die 1997-1999. Confidential enquiries into maternal deaths 2001. Dorchester: RCOG Press, 2001, Available at:http://www.cemach.org.uk/publications.htm (accessed 3rd October 2005).
17. de Haan G-J, Edelbroek P, Segers J, et al. Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study. Neurology 2004;63:571-3.