Chromogranin A in gastric neuroendocrine tumours: An immunohistochemical and biochemical study with region-specific antibodies

Virchows Archiv

Volumn 448, Issue 4, 2006, Pages 399-406

  Tartaglia, Andreas ^a   Portela Gomes, Guida M ^b,c   Öberg, Kjell ^d   Vezzadini, Paolo ^a   Foschini, Maria P ^a   Stridsberg, Mats ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF LISBON   (Portugal)

^c UPPSALA UNIVERSITY   (Sweden)

^d UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chromogranin A; ECLomas; Enterochromaffin like cells

Indexed keywords

CHROMOGRANIN A; EPITOPE; MONOCLONAL ANTIBODY; PANCREASTATIN; TUMOR ANTIGEN;

ADULT; AGED; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ARTICLE; CELL HYPERPLASIA; CHEMICAL ANALYSIS; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); ENTEROCHROMAFFIN CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NEOPLASM; NEUROENDOCRINE TUMOR; PATIENT; PLASMA; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STOMACH BIOPSY; STOMACH TUMOR;

AGED; AGED, 80 AND OVER; CHROMOGRANIN A; ENTEROCHROMAFFIN-LIKE CELLS; EPITOPES; FEMALE; GASTRIC MUCOSA; HUMANS; HYPERPLASIA; MALE; MIDDLE AGED; NEUROENDOCRINE TUMORS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 33645576068     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-005-0113-1     Document Type: Article

References (40)

1. Cadiot G, Lehy T, Mignon M (1993) Gastric endocrine cell proliferation and fundic argyrophil carcinoid tumors in patients with the Zollinger-Ellison syndrome. Acta Oncol 32:135-140
2. Conlon JM, Hamberger B, Grimelius L (1992) Isolations of peptides arising from the specific post-translational processing of chromogranin A and chromogranin B from human pheochomocytoma tissue. Peptides 13:639-644
3. Creutzfeldt W (1988) The achlorydria-carcinoid sequence: role of gastrin. Digestion 39:61-79
4. Cui G, Qvigstad G, Falkmer S, Sandvik AK, Kawase S, Waldum HL (2000) Spontaneous ECLomas in cotton rats (Sigmodon hispidus): tumors occurring in hypoacidic/hypergastrinaemic animals with normal parietal cells. Carcinogenesis 21:23-27
5. Curry WJ, Shaw C, Johnston CF, Thim L, Buchanan KD (1992) Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour. FEBS Lett 301:319-321
6. Drees BM, Rouse J, Johnson J, Hamilton JW (1991) Bovine parathyoid glands secrete a 26-kDa N-terminal fragment of chromogranin-A which inhibits parathyroid cell secretion. Endocrinology 129:3381-3387
7. Eissele R, Anlauf M, Schafer MK, Eiden LE, Arnold R, Weihe E (1999) Expression of vesicular monoamine transporters in endocrine hyperplasia and endocrine tumors of the oxyntic stomach. Digestion 60:428-439
8. Eskeland NL, Zhou A, Dinh TQ, Wu H, Parmer RJ, Mains RE, O'Connor DT (1996) Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway. J Clin Invest 98:148-156
9. Fasciotto BH, Trauss CA, Greely GH, Cohn DV (1993) Parastatin (porcine chromogranin A 347-419), a novel chromogranin A-derived peptide, inhibits parathyroid cell secretion. Endocrinology 133:461-466
10. Galindo E, Rill A, Bader MF, Aunis D (1991) Chromostatin, a 20-amino acid peptide derived from chromogranin A, inhibits chromaffin secretion. Proc Natl Acad Sci U S A 88:1426-1430
11. Granberg D, Wilander E, Stridsberg M, Granerus G, Skogseid B, Öberg K (1998) Clinical symptoms, hormone profiles, treatment, and prognosis in patients with gastric carcinoids. Gut 43:223-228
12. Hakanson R, Ding KQ, Norlen P, Chen D (1995) Circulating pancreastatin is a marker for the enterochromaffin-like cells of the rat stomach. Gastroenterology 108:1445-1452
13. Helle KB, Aardal S, Reed RK, Elsayed S (1990) N-terminal fragment of bovine chromogranin A inhibits the contractile response to endothelin-1 in human venous and arterial isolated fragments. J Physiol (London) 430:40P
14. Hsu SM, Raine T, Fanger H (1981) Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580
15. Kirchmair R, Leitner B, Fischer-Colbrie R, Marksteiner J, Hogue-Angeletti R, Winkler H (1995) Large variations in the proteolytic formation of a chromogranin A-derived peptide (GE-25) in neuroendocrine tissues. Biochem J 310:331-336
16. Kleveland PM, Haugen SE, Waldum HL (1985) The preparation of bioactive 125I-gastrin, using lodo-gen as oxidizing agent, and the use of this tracer in receptor studies. Scand J Gastroenterol 20:569-576
17. Krüger PG, Mahata SK, Helle KB (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul Pept 114:29-35
18. Lloyd RV, Wilson BS (1983) Specific endocrine tissue marker defined by a monoclonal antibody. Science 222:628-630
19. Mahata SK, O'Connor DT, Mahata M, Yoo SH, Taupenot L, Wu H, Gill BM, Parmer RJ (1997) Novel autocrine feedback control of catecholamine release. A discrete chromogranin A fragment is a noncompetitive nicotinic cholinergic antagonist. J Clin Invest 100:1623-1633
20. Muller J, Kirchner T, Muller-Hermelink HK (1987) Gastric endocrine cell hyperplasia and carcinoid tumors in atrophic gastritis type A. Am J Surg Pathol 11:909-917
21. O'Connor DT, Takiyyuddin MA, Cervenka JH, Parmer RJ, Barbosa JA, Chang YM, Hsiao RJ (1990) Circulating chromogranin A as a diagnostic tool in clinical chemistry. Acta Histochem Suppl 38:27-33
22. Portela-Gomes GM, Stridsberg M (2001) Selective processing of chromogranin A in the different islet cells in human pancreas. J Histochem Cytochem 49:483-490
23. Portela-Gomes GM, Stridsberg M (2002) Chromogranin A in the human gastrointestinal tract: an immunocytochemical study with region specific antibodies. J Histochem Cytochem 50:1487-1492
24. Portela-Gomes GM, Grimelius L, Johansson H, Wilander E, Stridsberg M (2001) Chromogranin A in human neuroendocrine tumors - an immunohistochemical study with region-specific antibodies. Am J Surg Pathol 25:1261-1267
25. Portela-Gomes GM, Grimelius L, Stridsberg M, Puppa G, Bresaola E, Viale G, Pelosi G (2005) Expression of amino acid sequences of the chromogranin A molecule and synaptic vesicle protein 2 in neuroendocrine tumors of the lung. Virchows Arch 446:604-612
26. Qvigstad G, Falkmer S, Westre B, Waldum HL (1999) Clinical and histopathological tumour progression in ECL cell carcinoids ("ECLomas" ). APMIS 107:1085-1092
27. Rappel S, Altendorf-Hofmann A, Stolte M (1995) Prognosis of gastric carcinoid tumours. Digestion 56:455-462
28. Rindi G, Bordi C, Rappel S, La Rosa S, Stolte M, Solcia E (1996) Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World J Surg 20:168-171
29. Roberts LJ 2nd, Bloomgarden ZT, Marney SR Jr, Rabin D, Oates JA (1983) Histamine release from a gastric carcinoid: provocation by pentagastrin and inhibition by somatostatin. Gastroenterology 84:272-275
30. Robinson M (1999) Review article: current perspectives on hypergastrinaemia and enterochromaffin-like-cell hyperplasia. Aliment Pharmacol Ther13:5-10
31. Simonsson M, Eriksson S, Hakanson R, Lind T, Lonroth H, Lundell L, O'Connor DT, Sundler F (1988) Endocrine cells in the human oxyntic mucosa - a histochemical study. Scand J Gastroenterol 23:1089-1099
32. Solcia E, Capella C, Sessa F, Rindi G, Cornaggia M, Riva C, Villani L (1986) Gastric carcinoids and related endocrine growths. Digestion 35:3-22
33. Solcia E, Bordi C, Creutzfeldt W, Dayal Y, Dayan AD, Falkmer S, Grimelius L, Havu N (1988) Histopathological classification of nonantral gastric endocrine growths in man. Digestion 41:185-200
34. Stridsberg M, Eriksson B, Öberg K, Janson ET (2004) A panel of 11 region-specific radioimmunoassays for measurement of human chromogranin A. Regul Pept 117:219-227
35. Strub JM, Sorokine O, Van Dorsselaer A, Aunis D, Metz-Boutigue MH (1997) Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities. J Biol Chem 272:11928-11936
36. Tatemoto K, Efendic S, Mutt V, Makk G, Feistner GJ, Barchas JD (1986) Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Nature (London) 324:476-478
37. Thomas RM, Baybick JH, Elsayed AM, Sobin LH (1994) Gastric carcinoids - an immunohistochemical and clinicopathologic study of 104 patients. Cancer 73:2053-2058
38. Waldum HL, Brenna E, Sandvik AK (1998) Relationship of ECL cells and gastric neoplasia. Yale J Biol Med 71:325-335
39. Waldum HL, Sandvik AK, Idle JR (1998) Gastrin is the most important factor in ECL tumorigenesis. Gastroenterology 114:1113-1115
40. Wilander E, Nordgren H, Öberg K (1986) Nonantral gastric carcinoid tumours associated to hypergastrinaemia. Acta Med Scand 219:393-397