Morphometric analysis of brain lesions in rat fetuses prenatally exposed to low-level lead acetate: Correlation with lipid peroxidation

Histology and Histopathology

Volumn 21, Issue 4-6, 2006, Pages 609-617

  Villeda Hernandez J ^a   Mendez Armenta M ^a   Barroso Moguel, R ^a   Trejo Solis, M C ^a   Guevara, J ^a   Rios, C ^a  

^a NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

Author keywords

Brain; Fetuses; Lead; Lipid peroxidation; Placenta; Umbilical cord

Indexed keywords

DRINKING WATER; LEAD ACETATE; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN CELL; BRAIN DAMAGE; BRAIN EDEMA; BREEDING; CEREBELLUM; CEREBROVASCULAR DISEASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; FEMALE; FETUS; FETUS DISEASE; FLUORESCENCE; HISTOPATHOLOGY; LEAD BLOOD LEVEL; LEAD POISONING; LIPID PEROXIDATION; MICROSCOPY; MORPHOMETRICS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARIETAL LOBE; PLACENTA DISORDER; PRENATAL EXPOSURE; RAT; RAT STRAIN; THALAMUS; UMBILICAL CORD;

ANIMALS; BRAIN; BRAIN CHEMISTRY; BRAIN EDEMA; CEREBELLUM; CEREBRAL CORTEX; CORPUS STRIATUM; FEMALE; HISTOCYTOCHEMISTRY; LEAD; LIPID PEROXIDATION; LIPIDS; ORGANOMETALLIC COMPOUNDS; PLACENTA; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL INJURIES; RATS; RATS, WISTAR; THALAMUS; UMBILICAL CORD;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33645557774     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Adonaylo V.N. and Oteiza P.I. (1999). Lead intoxication: Antioxidant defenses and oxidative and oxidative damage in rat brain. Toxicology 135, 79-85.
2. Angle C.R. (1993). Childhood lead poisoning and its treatment. Annu. Rev. Pharmacol. Toxicol 33, 409-434.
3. Antonio M.T. and Copras I. (1999). Neurochemical changes in newborn rat's brain after gestational cadmium and lead exposure. Toxicol. Lett. 104, 1-9.
4. Antonio M.T., Corredor L. and Leret M.L. (2003). Study of the activity of several brain enzymes like markers of the neurotoxicity induced by perinatal exposure to lead and/or cadmium. Toxicol. Lett. 143, 331-340.
5. Burdette L.J. and Goldstein R. (1986). Long-term behavioral and electrophysiological changes associated with lead exposure at different stages of brain development in the rat. Dev. Brain Res. 29, 101-110.
6. Christian G.D. (1969). Medicine, trace metals and atomic absorption spectroscopy. Ann. Chem. 41, 24A-40A.
7. Daggett D., Oberley T.D., Nelson S.A., Wright L.S., Kornguth S.E. and Siegel F.L. (1998). Effects of lead on the rat kidney and liver: GST expression and oxidative stress. Toxicology 128, 191-206.
8. Davis J.M., Elias R.W. and Grant L.D. (1993). Current issues in human lead exposure and regulation of lead. Neurotoxicology 14, 15-27.
9. Ding Y., Gonick H.C. and Vaziri N.D. (2000). Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells. Am. J. Hypertens. 13, 552-555.
10. Donaldson W.E. and Knowles S.O. (1993). Is lead toxicosis a reflection of altered fatty acid composition of membranes? Comp. Biochem. Physiol. C 104, 377-379.
11. Enhart C.B. (1992). A critical review of low-level prenatal lead exposure in the human: I. Effects on the fetus a newborn. Reprod. Toxicol, 6, 9-19.
12. Ercal N., Neal R., Treerapthan P., Lutz M.P., Hammond T.C., Dennery P.A. and Spitz D.R. (2000). A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fischer 344 rats. Arch. Environ. Toxicol. 39, 251-256.
13. Falcon M., Viñas P. and Luna A. (2003). Placental Lead and outcome of pregnancy. Toxicology 185, 59-66.
14. Finkelstein Y., Markowitz E.M. and Rosen F.J. (1998). Low-level lead-induced neurotoxicity in children: an update on central nervous system effects. Brain Res. Rev. 2, 168-176.
15. Flowler B., Bellinger D., Chilsom J., Falk H. and Flega A.R. (1993). Measuring lead exposure in infants, children, and other sensitive populations. Waschington. DC: National Academic Press. pp 150-200.
16. Furman A. and Laleli M. (2001). Maternal and umbilical cord blood lead levels: An Istanbul study. Arch. Environ. Health 56, 26-28
17. 3H-dopamine, and 3H-DOPA in various regions of the brain. J. Neurochem. 13, 655-699.
18. Gomaa A., Hu H., Bellinger D., Schwartz J., Tsaih S.W., Gonzalez-Cossio T., Schnaas., Peterson K., Aro A. and Hernandez-Avila A. (2002). Maternal bone lead as an Independent risk factor for fetal neurotoxicity: A prospective study. Pediatrics 110, 110-118.
19. Goyer A.R. (1993). Lead toxicity: Current concerns. Environ. Health Perspect. 100, 177-187.
20. Gulson B.L., Jameson C.W., Matieffey K.R., Mizon K.J., Mizon M.J., Korsh M.J. and Vimpani G. (1997). Pregnancy increases movilization of lead from maternal skeleton. J. Lab. Clin. Med. 130, 51-62.
21. Hernández-Avila M., Sanin L.H., Romieu I., Palazuelos E., Tapia-Conyer R., Olaiz G., Rojas R. and Navarrete J. (1997). Higher milk intake during and umbilical cord levels in postpartum women. Environ. Res. 74, 116-121.
22. Hirano A. and Iwata M. (1989). Neuropathology of lead intoxication. In: Intoxication of the nervous system. Part 1. Vinken P. J., and Beuyn G.W. (eds). North-Holland Publishing Company. Amsterdam-New York. Oxford. pp 35-64.
23. Invengar G.V. and Rapp A. (2001). Human placenta as a "dual" biomarker for monitoring fetal and maternal environment with special reference to potentially toxic trace elements. Part 3: Toxic trace elements in placenta and placenta as a biomarker for these elements. Sci. Total. Environ. 280, 221-228.
24. Jaako-Movits K., Zharkovsky T., Romantchick O., Jurgenson M., Merisalu E., Lenne-Triin H. and Zharkovsky A. (2005). Developmental lead exposure impairs contextual fear conditioning and reduce adult hippocampal neurogenesis in the rat brain. Int J. Devl. Neurosci. 23, 627-635.
25. Kern M., Audesirk T. and Audesirk C. (1993). Effects of inorganic lead on the differentiation and growth of cortical neurons in culture. Neurotoxicology 14, 319-327.
26. Korpela H., Louvenia E. and Kauppila A. (1986). Lead and cadmium concentrations in maternal and umbilical cord blood, amniotic fluid, placenta, and amniotic membranes. Am. J Obstet. Gynecol. 155, 1086-1089.
27. Lowry O.H., Rosebroug N.J. and Farr A.L. (1951). Protein measurement the folin-phenol reagent. J. Biol. Chem. 193, 265-275.
28. Luna G. (1995). Manual of histological staining methods of the Armed Forces Institute Pathology. Washington, DC. American Registry of Pathology. p 258.
29. Mameli M.A., Caria F., Melis A., Solinas C., Tavera A., Ibba M., Tocco C., Flore and Radanccio F.S. (2001). Neurotoxic effect of lead at low concentrations. Brain Res. Bull. 55, 269-275.
30. Miller D.T., Paschal D.C., Gunter E.W., Stroud P.E. and D'Angelo J. (1987). Determination of lead in blood using electrothermal atomization absorption spectrometry, a L'vov platform and matrix modifier. Analyst 112, 181-194.
31. Moreira E.G., Valssilief I. and Vassilief V. (2001a). Developmental lead exposure: behavioral alterations in the short- and long-term. Neurotoxicol. Teratol. 23, 489-495.
32. Moreira E.G., Rosa G.J.M., Barros S.B.M., Vassilief V.S. and Vassilief I. (2001b). Antioxidant defense in rat brain regions after developmental lead exposure. Toxicology 169, 145-151.
33. Needleman H.L. (1990). What can the study of lead teach us about other toxicants?. Environ. Health Perspect. 86, 183-189.
34. Ping-Chi H. and Yueliang L.G. (2002). Antioxidant nutrients and lead toxicity. Toxicology 180, 33-44.
35. Press M.E. (1977). Lead encephalopathy in neonatal long-evans rats: Morphology studies. J. Neuropathol. Exp. Neurol. 36, 169-193.
36. Robin B.K., Tiffany H., Geeta S. and Rebecca, N.B. (2003). Clinical significance of the umbilical cord twist. Am. J. Obstet. Gynecol. 189, 736-739.
37. Sandhier R., Julka D. and Gill K.D. (1994). Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes. Pharmacol. Toxicol. 74, 66-71.
38. Santamaría A. and Ríos C. (1993). MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neurosci. Lett. 159, 51-54.
39. Shafiq-Ur-Rehman S. (1984). Lead-induced regional lipid peroxidation in brain. Toxicol. Lett. 21, 333-337.
40. Shukla G.S., Hussain T. and Chandra S.V. (1987). Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats. Life Sci. 41, 2215-2221.
41. Soltaninejad K., Kebriaeezadeh A., Minaiee B., Ostad S.N., Hosseini R., Azizi E. and Abdollahi M. (2003). Biochemical and ultrastructural evidences for toxicity of lead through free radicals in rat brain. Hum. Exp. Toxicol. 22, 417-423.
42. Villeda-Hernández J., Barroso-Moguel R., Méndez-Armenta M., Nava-Ruíz C., Huerta Romero R. and Ríos C. (2001). Enhanced brain regional lipid peroxidation in developing rats exposed to low-level lead acetate. Brain Res. Bull. 55, 247-251.
43. Wells A.G., Howell J.M.C. and Gopinanth C. (1976). Experimental lead encephalopathy of calves: Histological observations on the nature and distribution of the lesions. Neuropathol. App. Neurobiol. 2, 1975-1980.
44. Weis S. (1991). Morphometry in the neurosciences In: Image processing and computer graphics investigation. Theory and Applications. Wenger E. and Dimitov L. (eds). Oldenburg Verlag, Minich. pp 306-326.
45. West W., Knigth E., Edwards C., Manning M., Spurlock B. and James H. (1994). Maternal low level lead and pregnancy outcomes J. Nutr. 124, 981S-986S.