메뉴 건너뛰기




Volumn 31, Issue 1, 2006, Pages 22-27

MPC-7869. Prostate cancer therapy treatment of Alzheimer's dementia

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; E 7869; FLURBIPROFEN; FLURIZAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MPC 7869; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PROSTATE SPECIFIC ANTIGEN; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; ZYMOSAN;

EID: 33645552739     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2006.031.01.961798     Document Type: Article
Times cited : (2)

References (48)
  • 1
    • 33645553378 scopus 로고    scopus 로고
    • (The Boots Company plc). 2-(Mono- and difluoro-4-biphenyl)propionic acids. US 3755427
    • Adams, S.S., Bernard, J., Nicholson, J.S., Ribera Blancafort, A. (The Boots Company plc). 2-(Mono- and difluoro-4-biphenyl)propionic acids. US 3755427.
    • Adams, S.S.1    Bernard, J.2    Nicholson, J.S.3    Ribera Blancafort, A.4
  • 2
    • 33645550551 scopus 로고    scopus 로고
    • (Pfizer Inc.). Processes for the preparation of hydratropic acids and esters. US 4266069, JP 1981097247
    • Walker, J.A. (Pfizer Inc.). Processes for the preparation of hydratropic acids and esters. US 4266069, JP 1981097247.
    • Walker, J.A.1
  • 3
    • 33645552763 scopus 로고    scopus 로고
    • (The Boots Company plc). Preparation of therapeutic compounds. DE 2613817, FR 2306192, GB 1514812, JP 1976127042, JP 1981095147, US 4188491, US 4304931
    • Nicholson, J.S., Turner, J.L. (The Boots Company plc). Preparation of therapeutic compounds. DE 2613817, FR 2306192, GB 1514812, JP 1976127042, JP 1981095147, US 4188491, US 4304931.
    • Nicholson, J.S.1    Turner, J.L.2
  • 4
    • 33645537140 scopus 로고    scopus 로고
    • (The Boots Company plc). Process for preparing substantially pure enantiomers of phenylpropionic acids. WO 1994012460
    • Hardy, R., Coe, P.F., Hirst, A., O'Donnell, H.O. (The Boots Company plc). Process for preparing substantially pure enantiomers of phenylpropionic acids. WO 1994012460.
    • Hardy, R.1    Coe, P.F.2    Hirst, A.3    O'Donnell, H.O.4
  • 5
    • 33645539201 scopus 로고    scopus 로고
    • (Sumitomo Pharmaceuticals Co., Ltd.). Method of preparing optically active carboxylic acid. JP 2000143580
    • Takahashi, K., Takeda, T. (Sumitomo Pharmaceuticals Co., Ltd.). Method of preparing optically active carboxylic acid. JP 2000143580.
    • Takahashi, K.1    Takeda, T.2
  • 6
    • 0029098228 scopus 로고
    • Resolution of racemic flurbiprofen by lipase-mediated esterification in organic solvent
    • Morrone, R., Nicolosi, G., Patti, A., Piattelli, M. Resolution of racemic flurbiprofen by lipase-mediated esterification in organic solvent. Tetrahedron Asymmetry 1995, 6: 1773-8.
    • (1995) Tetrahedron Asymmetry , vol.6 , pp. 1773-1778
    • Morrone, R.1    Nicolosi, G.2    Patti, A.3    Piattelli, M.4
  • 8
    • 33645545212 scopus 로고    scopus 로고
    • (Tosoh Corp.). Method of preparing optically active α-arylpropionic acid. JP 2003169691
    • Hanzawa, S., Kakitani, H., Ohta, H. (Tosoh Corp.). Method of preparing optically active α-arylpropionic acid. JP 2003169691.
    • Hanzawa, S.1    Kakitani, H.2    Ohta, H.3
  • 9
    • 3242884127 scopus 로고    scopus 로고
    • The role of nonsteroidal antiinflammatory drugs in cancer chemoprevention
    • Young, C.Y.F. The role of nonsteroidal antiinflammatory drugs in cancer chemoprevention. Drugs Fut 2004, 29: 467-78.
    • (2004) Drugs Fut , vol.29 , pp. 467-478
    • Young, C.Y.F.1
  • 10
    • 0033631452 scopus 로고    scopus 로고
    • Inverse association of prostate cancer and non-steroidal anti-inflammatory drugs (NSAIDs): Results of a case-control study
    • Nelson, J.E., Harris, R.E. Inverse association of prostate cancer and non-steroidal anti-inflammatory drugs (NSAIDs): Results of a case-control study. Oncol Rep 2000, 7: 169-70.
    • (2000) Oncol Rep , vol.7 , pp. 169-170
    • Nelson, J.E.1    Harris, R.E.2
  • 11
  • 13
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal antiinflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
    • Etminan, M., Gill, S., Sar, A. Effect of non-steroidal antiinflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies. BMJ - Br Med J 2003, 327: 128-32.
    • (2003) BMJ - Br Med J , vol.327 , pp. 128-132
    • Etminan, M.1    Gill, S.2    Sar, A.3
  • 16
    • 0030733305 scopus 로고    scopus 로고
    • Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
    • Riendeau, D., Charleson, S., Cromlish, W. et al. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can J Physiol Pharmacol 1997, 75(9): 1088-95.
    • (1997) Can J Physiol Pharmacol , vol.75 , Issue.9 , pp. 1088-1095
    • Riendeau, D.1    Charleson, S.2    Cromlish, W.3
  • 17
    • 17844374592 scopus 로고    scopus 로고
    • Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease
    • Gasparini, L., Ongini, E., Wilcock, D., Morgan, D. Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain Res Rev 2005, 48: 400-8.
    • (2005) Brain Res Rev , vol.48 , pp. 400-408
    • Gasparini, L.1    Ongini, E.2    Wilcock, D.3    Morgan, D.4
  • 18
    • 0036826903 scopus 로고    scopus 로고
    • Selective inhibition of Aβ42 production by NSAID R-enantiomers
    • Morihara, T., Chu, T., Ubeda, O., Beech, W., Cole, G.M. Selective inhibition of Aβ42 production by NSAID R-enantiomers. J Neurochem 2002, 83: 1009-12.
    • (2002) J Neurochem , vol.83 , pp. 1009-1012
    • Morihara, T.1    Chu, T.2    Ubeda, O.3    Beech, W.4    Cole, G.M.5
  • 20
    • 85047691727 scopus 로고    scopus 로고
    • NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
    • Eriksen, J.L., Sagi, S.A., Smith, T.E. et al. NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo. J Clin Invest 2003, 112: 440-9.
    • (2003) J Clin Invest , vol.112 , pp. 440-449
    • Eriksen, J.L.1    Sagi, S.A.2    Smith, T.E.3
  • 21
    • 33645535519 scopus 로고    scopus 로고
    • Chronic treatment of transgenic APP mice with R-flurbiprofen
    • (Nov 8-12, New Orleans), Abst 295.22
    • Eriksen, J.L., Nicolle, M.M., Prescott, S. et al. Chronic treatment of transgenic APP mice with R-flurbiprofen. 33rd Annu Meet Soc Neurosci (Nov 8-12, New Orleans) 2003, Abst 295.22.
    • (2003) 33rd Annu Meet Soc Neurosci
    • Eriksen, J.L.1    Nicolle, M.M.2    Prescott, S.3
  • 22
    • 33645553875 scopus 로고    scopus 로고
    • Long-term, but not short-term, R-flurbiprofen treatment ameliorates cognitive deficits in transgenic APP mice
    • (Oct 23-27, San Diego), Abst 674.6
    • Nicolle, M.M., Prescott, S., Murphy, M.P., Kukar, T., Eriksen, J.L., Koo, E.H., Golde, T.E. Long-term, but not short-term, R-flurbiprofen treatment ameliorates cognitive deficits in transgenic APP mice. 34th Annu Meet Soc Neurosci (Oct 23-27, San Diego) 2004, Abst 674.6.
    • (2004) 34th Annu Meet Soc Neurosci
    • Nicolle, M.M.1    Prescott, S.2    Murphy, M.P.3    Kukar, T.4    Eriksen, J.L.5    Koo, E.H.6    Golde, T.E.7
  • 24
    • 10344257238 scopus 로고    scopus 로고
    • R-Isomer of flurbiprofen decreases colonic cell proliferation without causing significant small bowel ulceration
    • Abst 4
    • McCracken, J.D., Wechter, W.J., Quiggle, D., Liu, Y.J., Chase, R., Mineyama, Y. R-Isomer of flurbiprofen decreases colonic cell proliferation without causing significant small bowel ulceration. J Clin Pharmacol 1996, 36(6): Abst 4.
    • (1996) J Clin Pharmacol , vol.36 , Issue.6
    • McCracken, J.D.1    Wechter, W.J.2    Quiggle, D.3    Liu, Y.J.4    Chase, R.5    Mineyama, Y.6
  • 29
    • 33645544216 scopus 로고    scopus 로고
    • Gene expression profiling in prostate cancer treated with R-flurbiprofen: Identification of prostate stem-cell antigen as a flurbiprofen-regulated gene
    • (Oct 16-20, Seattle), Abst A72
    • Chen, C.-S., Reiter, R., Zemskova, M., Lilly, M. Gene expression profiling in prostate cancer treated with R-flurbiprofen: Identification of prostate stem-cell antigen as a flurbiprofen-regulated gene. 3rd Annu Int Conf Front Cancer Prev Res (Oct 16-20, Seattle) 2004, Abst A72.
    • (2004) 3rd Annu Int Conf front Cancer Prev Res
    • Chen, C.-S.1    Reiter, R.2    Zemskova, M.3    Lilly, M.4
  • 31
    • 33645543998 scopus 로고    scopus 로고
    • Cyclooxygenase-2 gene expression is reduced by R-flurbiprofen in a human colon cancer xenograft
    • Chaudhary, K.K., McCracken, J.D., Pappas, J.M., Berk, L.S., Santamaria, D.A. Cyclooxygenase-2 gene expression is reduced by R-flurbiprofen in a human colon cancer xenograft. J Invest Med 1999, 47(2): 47A.
    • (1999) J Invest Med , vol.47 , Issue.2
    • Chaudhary, K.K.1    McCracken, J.D.2    Pappas, J.M.3    Berk, L.S.4    Santamaria, D.A.5
  • 33
    • 0038604334 scopus 로고    scopus 로고
    • Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers
    • Grösch, S., Tedegar, I., Schilling, K., Maier, T., Niederberger, E., Geisslinger, G. Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. FASEB J 2003, 17: 1316-8.
    • (2003) FASEB J , vol.17 , pp. 1316-1318
    • Grösch, S.1    Tedegar, I.2    Schilling, K.3    Maier, T.4    Niederberger, E.5    Geisslinger, G.6
  • 35
    • 0346940709 scopus 로고    scopus 로고
    • Phase I single-dose pharmacokinetics and lack of enantiomeric bioinversion of E-7869 (R-flurbiprofen)
    • Abst PI-56
    • Murray, E.D. Jr., Quiggle, D., Gibson, K., Leipold, D., Loughman, B., Wechter, W. Phase I single-dose pharmacokinetics and lack of enantiomeric bioinversion of E-7869 (R-flurbiprofen). Clin Pharmacol Ther 2000, 67(2): Abst PI-56.
    • (2000) Clin Pharmacol Ther , vol.67 , Issue.2
    • Murray Jr., E.D.1    Quiggle, D.2    Gibson, K.3    Leipold, D.4    Loughman, B.5    Wechter, W.6
  • 37
    • 33645539200 scopus 로고    scopus 로고
    • Flurizan, (MPC-7869, (R)-flurbiprofen) a selective Aβ-42 lowering agent in patients with mild to moderate Alzheimer's disease: A randomised, placebo-controlled, double blind trial
    • Abst FC7.4
    • Wilcock, G., Black, S., Haworth, J., Laughlin, M., Hendrix, S., Binger, M.-H., Zavitz, K., Swabb, E., Hobden, A. Flurizan, (MPC-7869, (R)-flurbiprofen) a selective Aβ-42 lowering agent in patients with mild to moderate Alzheimer's disease: A randomised, placebo-controlled, double blind trial. Int Psychogeriatr 2005, 17(Suppl. 2): Abst FC7.4.
    • (2005) Int Psychogeriatr , vol.17 , Issue.SUPPL. 2
    • Wilcock, G.1    Black, S.2    Haworth, J.3    Laughlin, M.4    Hendrix, S.5    Binger, M.-H.6    Zavitz, K.7    Swabb, E.8    Hobden, A.9
  • 38
    • 33645549113 scopus 로고    scopus 로고
    • A placebo-controlled, double-blind trial of the selective Aβ-42 lowering agent, Flurizan (MPC-7869, (R)-flurbiprofen) in patients with mild to moderate Alzheimer's disease
    • (June 18-21, Washington DC), Abst 02-01-05
    • Wilcock, G., Black, S., Haworth, J., Laughlin, M., Hendrix, S., Binger, M.-H., Zavitz, K., Swabb, E., Hobben, A. A placebo-controlled, double-blind trial of the selective Aβ-42 lowering agent, Flurizan (MPC-7869, (R)-flurbiprofen) in patients with mild to moderate Alzheimer's disease. Alzheimer's Assoc Int Conf Prev Dement (June 18-21, Washington DC) 2005, Abst 02-01-05.
    • (2005) Alzheimer's Assoc Int Conf Prev Dement
    • Wilcock, G.1    Black, S.2    Haworth, J.3    Laughlin, M.4    Hendrix, S.5    Binger, M.-H.6    Zavitz, K.7    Swabb, E.8    Hobben, A.9
  • 39
    • 33645554096 scopus 로고    scopus 로고
    • A placebo-controlled, double-blind trial of the selective Aβ42-lowering agent Flurizan in patients with mild to moderate Alzheimer's disease: Efficacy, safety, and follow-on study results
    • (Nov 12-16, Washington DC), Abst 586.6
    • Black, S., Wilcock, G., Haworth, J., Hendrix, S., Zavitz, K., Binger, M., Roch, J., Laughlin, M., Swabb, E., Hobden, A. A placebo-controlled, double-blind trial of the selective Aβ42-lowering agent Flurizan in patients with mild to moderate Alzheimer's disease: Efficacy, safety, and follow-on study results. 35th Annu Meet Soc Neurosci (Nov 12-16, Washington DC) 2005, Abst 586.6.
    • (2005) 35th Annu Meet Soc Neurosci
    • Black, S.1    Wilcock, G.2    Haworth, J.3    Hendrix, S.4    Zavitz, K.5    Binger, M.6    Roch, J.7    Laughlin, M.8    Swabb, E.9    Hobden, A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.