-
1
-
-
16244403172
-
-
PCT Int. Appl. WO 2004/ 072031, 26 August 2004
-
(a) Fyfe, M. C. T.; Gardner, L. S.; Nawano, M.; Procter, M. J.; Rasamison, C. M.; Schofield, K. L.; Shah, V. K.; Yasuda, K. PCT Int. Appl. WO 2004/ 072031, 26 August 2004; Chem. Abstr. 2004, 141, 225496.
-
(2004)
Chem. Abstr.
, vol.141
, pp. 225496
-
-
Fyfe, M.C.T.1
Gardner, L.S.2
Nawano, M.3
Procter, M.J.4
Rasamison, C.M.5
Schofield, K.L.6
Shah, V.K.7
Yasuda, K.8
-
2
-
-
33645550326
-
-
PCT Int. Appl. WO 2004/072066, 26 August 2004
-
(b) Fyfe, M. C. T.; Gardner, L. S.; Nawano, M.; Procter, M. J.; Williams, G. M.; Witter, D.; Yasuda, K.; Rasamison, C. M.; Castelhano, A. PCT Int. Appl. WO 2004/072066, 26 August 2004; Chem. Abstr. 2004, 141, 225497.
-
(2004)
Chem. Abstr.
, vol.141
, pp. 225497
-
-
Fyfe, M.C.T.1
Gardner, L.S.2
Nawano, M.3
Procter, M.J.4
Williams, G.M.5
Witter, D.6
Yasuda, K.7
Rasamison, C.M.8
Castelhano, A.9
-
3
-
-
4444355871
-
-
and references therein
-
Böhm, H.-J.; Banner, D.; Bendels, S.; Kansy, M.; Kuhn, B.; Müller, K.; Obst-Sander, U.; Stahl, M. ChemBioChem 2004,5,637-643 and references therein.
-
(2004)
ChemBioChem
, vol.5
, pp. 637-643
-
-
Böhm, H.-J.1
Banner, D.2
Bendels, S.3
Kansy, M.4
Kuhn, B.5
Müller, K.6
Obst-Sander, U.7
Stahl, M.8
-
6
-
-
33645539430
-
-
U.S. Patent 4,046,768
-
(a) Krenzer, J.; Wu, C. C. U.S. Patent 4,046,768; Chem. Abstr. 1977, 87, 184508.
-
(1977)
Chem. Abstr.
, vol.87
, pp. 184508
-
-
Krenzer, J.1
Wu, C.C.2
-
7
-
-
33645538753
-
-
Br. Patent 1,579,771
-
(b) Wu, F.; Krenzer, J. Br. Patent 1,579,771; Chem. Abstr. 1978, 88,105336.
-
(1978)
Chem. Abstr.
, vol.88
, pp. 105336
-
-
Wu, F.1
Krenzer, J.2
-
8
-
-
33645536848
-
-
U.S. Patent 4,086,240
-
(c) Wu, C. C.; Krenzer, J. U.S. Patent 4,086,240; Chem. Abstr. 1978, 89,109486.
-
(1978)
Chem. Abstr.
, vol.89
, pp. 109486
-
-
Wu, C.C.1
Krenzer, J.2
-
9
-
-
33645535528
-
-
U.S. Patent 4,097,485
-
(d) Krenzer, J.; Wu, C. C. U.S. Patent 4,097,485; Chem. Abstr. 1978, 89, 197553.
-
(1978)
Chem. Abstr.
, vol.89
, pp. 197553
-
-
Krenzer, J.1
Wu, C.C.2
-
10
-
-
16244372569
-
-
PCT Int. Appl. WO 2004/063179, 29 July 2004
-
Weichert, A. G.; Barrett, D. G.; Heuser, S.; Riedl, R.; Tebbe, M. J.; Zaliani, A. PCT Int. Appl. WO 2004/063179, 29 July 2004; Chem. Abstr. 2004, 141, 157108.
-
(2004)
Chem. Abstr.
, vol.141
, pp. 157108
-
-
Weichert, A.G.1
Barrett, D.G.2
Heuser, S.3
Riedl, R.4
Tebbe, M.J.5
Zaliani, A.6
-
13
-
-
33645534759
-
-
PCT Int. Appl. WO 2005/014591, 17 February 2005
-
Mavro, J.; Vidal, L.; Saunier, J.-B. PCT Int. Appl. WO 2005/014591, 17 February 2005; Chem. Abstr. 2005, 142, 225134.
-
(2005)
Chem. Abstr.
, vol.142
, pp. 225134
-
-
Mavro, J.1
Vidal, L.2
Saunier, J.-B.3
-
14
-
-
0036186485
-
-
Yamamoto, H.; Eikuyu, Y.; Okuda, S.; Kawabata, K.; Takasugi, H.; Tanaka, H.; Matsumoto, S.; Matsumoto, Y.; Tawara, S. Bioorg. Med. Chem. 2002, 10, 1535-1545.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 1535-1545
-
-
Yamamoto, H.1
Eikuyu, Y.2
Okuda, S.3
Kawabata, K.4
Takasugi, H.5
Tanaka, H.6
Matsumoto, S.7
Matsumoto, Y.8
Tawara, S.9
-
15
-
-
0030053521
-
-
Yin, H.; Anders, M. W.; Jones, J. P. Chem. Res. Toxicol. 1996, 9, 50-57.
-
(1996)
Chem. Res. Toxicol.
, vol.9
, pp. 50-57
-
-
Yin, H.1
Anders, M.W.2
Jones, J.P.3
-
16
-
-
0001678224
-
-
English, J. P.; Clark, J. H.; Clapp, J. W.; Seeger, D.; Ebel, R. H. J. Am. Chem. Soc. 1946, 68, 453-457.
-
(1946)
J. Am. Chem. Soc.
, vol.68
, pp. 453-457
-
-
English, J.P.1
Clark, J.H.2
Clapp, J.W.3
Seeger, D.4
Ebel, R.H.5
-
21
-
-
0033458491
-
-
Shamma, T.; Buchholz, H.; Prakash, G. K. S.; Olah, G. A. Isr. J. Chem. 1999, 39, 207-210.
-
(1999)
Isr. J. Chem.
, vol.39
, pp. 207-210
-
-
Shamma, T.1
Buchholz, H.2
Prakash, G.K.S.3
Olah, G.A.4
-
22
-
-
0034605873
-
-
Hintermann, L.; Togni, A. Angew. Chem., Int. Ed. 2000, 39, 4359-4362.
-
(2000)
Angew. Chem., Int. Ed.
, vol.39
, pp. 4359-4362
-
-
Hintermann, L.1
Togni, A.2
-
23
-
-
0032763340
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-
The fluorination of acetamidothiophenes with F-TEDA is also problematic, affording very low yields of the desired fluorinated products: Kobarfard, F.; Kauffman, J. M.; Boyko, W. J. J. Heterocycl. Chem. 1999, 36, 1247-1251.
-
(1999)
J. Heterocycl. Chem.
, vol.36
, pp. 1247-1251
-
-
Kobarfard, F.1
Kauffman, J.M.2
Boyko, W.J.3
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25
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33645550447
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note
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The only other electrophilic fluorinating agents commercially available in bulk at present are 1-fluoropyridinium pyridine heptafluorodiborate [AccuFluor NFPy] and 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) [AccuFluor NFTh].
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26
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0037140727
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Schiavi, B.; Ahond, A.; Al-Mourabit, A.; Poupat, C.; Chiaroni, A.; Gaspard, C.; Potier, P. Tetrahedron 2002, 58, 4201-4215.
-
(2002)
Tetrahedron
, vol.58
, pp. 4201-4215
-
-
Schiavi, B.1
Ahond, A.2
Al-Mourabit, A.3
Poupat, C.4
Chiaroni, A.5
Gaspard, C.6
Potier, P.7
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27
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0028305834
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The formation of sulfones by reaction of aryllithiums with NFSi has been observed previously: Snieckus, V.; Beaulieu, F1; Mohri, K.; Han, W.; Murphy, C. K.; Davis, F. A. Tetrahedron Lett. 1994, 35, 3465-3468.
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 3465-3468
-
-
Snieckus, V.1
Beaulieu, F.2
Mohri, K.3
Han, W.4
Murphy, C.K.5
Davis, F.A.6
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28
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33645554388
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note
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It is believed that the proton source for the formation of 1c is NFSi itself, as quenching of the dianion with DMF gave a quantitative yield of the appropriate aldehyde.
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29
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33645539206
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note
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The difluorinated compound 2-tert-butoxycarbonylamino-4,5- difluorothiazole (5) was produced in 5-10% yield (determined by HPLC at 275 nm) when a larger quantity of t-BuLi (2.4 equiv) was employed.
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31
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33645544782
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available via the Internet
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This organometallic reagent was purchased on a multikilogram scale from Chemetall GmbH (Frankfurt a. M., Germany). CAUTION: t-BuLi is extremely pyrophoric and should be handled on a large scale only by experienced personnel. Solutions of t-BuLi react vigorously and often violently with oxygen, water, and other protic solvents. As a result, the reaction must be conducted with extreme care under a dry, oxygen free, inert atmosphere. Appropriate protective clothing should be worn, and a suitable safety shield should be employed. In case of fire, a dry-powder extinguisher should be used. For further information on the handling of t-BuLi solutions in large quantities, see: Bailey, W. F.; Longstaff, S. C. FMC Lithium Link, Fall 2000, tert-Butyllithium in Organic Synthesis (available via the Internet at http://www.fmclithium.com).
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FMC Lithium Link, Fall 2000, Tert-Butyllithium in Organic Synthesis
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Bailey, W.F.1
Longstaff, S.C.2
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