Development of a pilot-scale preparation of N-[[(5S)-3-[4-(1,1-dioxido-4- thiomorpholinyl)-3,5-difluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, PNU-288034, an oxazolidinone antibacterial agent

Organic Process Research and Development

Volumn 10, Issue 2, 2006, Pages 272-277

  Lu, Cuong V ^a   Chen, Jiong J ^b   Perrault, William R ^a   Conway, Brian G ^a   Maloney, Mark T ^a   Wang, Ying ^a  

^a PFIZER INC   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33645537973     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op050207i     Document Type: Article

References (7)

1. Greene, M. L.; Chen, J. J.; Maloney, M. T.; Lu, C. V. U.S. Patent 20030109525 A1, 2003.
2. Barbachyn, M.; Zurenko, R.; Edward, G.; U.S. Patent 6,605,609B2, 2003.
3. Perrault, W. R.; Pearlman, B. A.; Godrej, D. B.; Jeganathan, A.; Yamagata, K.; Chen, J. J.; Lu, C. V.; Herrinton, P. M.; Gadwood, R. C.; Chan, L.; Dorow, R. L.; Lyster, M. A.; Maloney, M. T.; Moeslein, J. A.; Greene, M. R.; Barbachyn, M. R. Org. Process Res. Dev. 2003, 7, 533-546.
4. Ford-Moore, A. H. J. Chem. Soc. 1949, 2433-2440.
5. Straley, J. M.; Fisher, J. G. U.S. Patent 3,585,182, 1971.
6. Chen, J. J.; Lu, C. V. U.S. Patent 6,774,231B2, 2004.
7. Chen, J. J.; Lu, C. V. Brockman, R. N. Tetrahedron Lett 2003, 44, 3459-3462.