Armodafinil. Treatment of excessive sleepiness α1- adrenoceptor agonist

Drugs of the Future

Volumn 31, Issue 1, 2006, Pages 17-21

  Boyd, B ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ARMODAFINIL; CEP 10952; CRL 40982; METHAMPHETAMINE; MODAFINIL; NUVIGIL; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ALERTNESS; ANXIETY; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; COCAINE DEPENDENCE; DEPRESSION; DIARRHEA; DIZZINESS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; EPWORTH SLEEPINESS SCALE; FATIGUE; HEADACHE; HUMAN; INSOMNIA; MEMORY; META ANALYSIS; NARCOLEPSY; NAUSEA; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; QUALITY OF LIFE; RAT; RHINOPHARYNGITIS; SHIFT WORK SLEEP DISORDER; SHIFT WORKER; SINGLE DRUG DOSE; SLEEP APNEA SYNDROME; SOMNOLENCE; SYSTEMATIC REVIEW; VOLUNTEER; WAKEFULNESS;

EID: 33645534153     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2006.031.01.957731     Document Type: Article

References (18)

1. Prisinzano, T., Podobinski, J., Tidgewell, K., Luo, M., Swenson, D. Synthesis and determination of the absolute configuration of the enantiomers of modafinil. Tetrahedron Asymmetry 2004, 15: 1053-8.
2. Lafon, L. (Cephalon France). (-)-Benzhydrylsulfinylacetamide, process for its preparation and its use in therapy. EP 0233106, FR 2593809, JP 1987190160, US 4927855.
3. Neckebrock, O., Courvoisier, L., Graf, S., Serrure, G., Coquerel, G., Rose, S., Besselievre, C., Mallet, F., Van Langevelde, A.J. (Cephalon France; Organisation de Synthese Mondiale Orsymonde). Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil. FR 2849029, EP 1572635, WO 2004060858.
4. Osorio-Lozada, A., Prisinzano, T., Olivo, H.F. Synthesis and determination of the absolute stereochemistry of the enantiomers of adrafinil and modafinil. Tetrahedron Asymmetry 2004, 15: 3811-5.
5. Castañer, J., Prous, J. Modafinil. Drugs Fut 1990, 15: 130-2.
6. Rebiere, F., Duret, G., Prat, L. (Cephalon France). Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation. EP 1516869, US 2005080256, US 2005222257, WO 2005028428.
7. Prous Science R&D Backgrounders: Steep apnea (online publication). Updated December 19, 2005.
8. Prous Science R&D Backgrounders: Narcolepsy (online publication). Updated November 3, 2005.
9. NDA filed for Nuvigil. DailyDrugNews.com (Daily Essentials) April 1, 2005.
10. Wisor, J.P., Dement, W.C., Aimone, L., Williams, M., Bozyczko-Coyne, D. R-Modafinil (armodafinil) produces dose-dependent increases in wake in rat without rebound hypersomnolence. 35th Annu Meet Soc Neurosci (Nov 12-16, Washington DC) 2005, Abst 310.3.
11. Niebler, G.E., on behalf of the Armodafinil 103 Study Group. A randomized, double-blind, placebo- and active-controlled evaluation of single doses of armodafinil in healthy subjects during a period of acute sleep loss. 1st Congr World Assoc Sleep Med (WASM) (Oct 15-18, Berlin) 2005, Abst P 194.
12. Wesnes, K., Niebler, G., Arora, S. The cognitive effects of armodafinil in patients with excessive sleepiness associated with obstructive sleep apnea/hypopnea, narcolepsy and shift work sleep disorder. J Psychopharmacol 2005, 19(5, Suppl.): Abst TC10.
13. Wesnes, K., Niebler, G., Arora, S. The cognitive effects of armodafinil in patients with excessive sleepiness associated with OSAHS, narcolepsy, and shift work sleep disorder. 18th Congr Eur Coll Neuropsychopharmacol (ECNP) (Oct 22-26, Amsterdam) 2005, Abst P.8.106.
14. Wesnes, K.A., Niebler, G.E., Snyder, H. Cognitive effects of armodafinil in patients with excessive sleepiness and obstructive sleep apnea/hypopnea, narcolepsy, or shift work sleep disorder. 1st Congr World Assoc Sleep Med (WASM) (Oct 15-18, Berlin) 2005, Abst P 208.
15. Hirshkowitz, M., Roth, T., Black, J., Wesnes, K., Arora, S., Niebler, G., White, D. Armodafinil as adjunct therapy improves wakefulness and fatigue in patients with obstructive sleep apnea/hypopnea syndrome. Sleep 2005, 28(Abstract Supplement): Abst 0531.
16. Black, J., Wesnes, K., Arora, S., Niebler, G., Roth, T. Efficacy and safety of armodafinil 150 or 250 mg as adjunct therapy for residual excessive sleepiness and fatigue associated with obstructive sleep apnea/hypopnea syndrome. Sleep 2005, 28(Abstract Supplement): Abst 0632.
17. Roth, T., Czeisler, C.A., Walsh, J.K., Wesnes, K.A., Williams, M., Niebler, G.E., Arora, S. Randomized, double-blind, placebo-controlled study of armodafinil for the treatment of excessive sleepiness associated with chronic shift work sleep disorder. Neuropsychopharmacology 2005, 30(Suppl. 1): S140.
18. Harsh, J., Rosenberg, R., Niebler, G.E., on behalf of the Armodafinil 3020 Study Group. A 12-week randomized, double-blind, placebo-controlled study of armodafinil in adults with excessive sleepiness associated with narcolepsy. 1st Congr World Assoc Sleep Med (WASM) (Oct 15-18, Berlin) 2005, Abst P 018.