메뉴 건너뛰기




Volumn 66, Issue 6, 2006, Pages 2928-2936

Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene

Author keywords

[No Author keywords available]

Indexed keywords

IMIDAZOLINE DERIVATIVE; NUTLIN 3A; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 33645521202     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2063     Document Type: Article
Times cited : (18)

References (39)
  • 2
  • 3
    • 0037349249 scopus 로고    scopus 로고
    • p53 and apoptosis: It's not just in the nucleus anymore
    • Manfredi JJ. p53 and apoptosis: it's not just in the nucleus anymore. Mol Cell 2003;11:552-4.
    • (2003) Mol Cell , vol.11 , pp. 552-554
    • Manfredi, J.J.1
  • 4
    • 18144434267 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis
    • Pietenpol JA, Stewart ZA. Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology 2002; 181-182:475-81.
    • (2002) Toxicology , vol.181-182 , pp. 475-481
    • Pietenpol, J.A.1    Stewart, Z.A.2
  • 5
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko LJ, Prives C. p53: puzzle and paradigm. Genes Dev 1996;10:1054-72.
    • (1996) Genes Dev , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 6
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-31.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 7
    • 13944278507 scopus 로고    scopus 로고
    • The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
    • Johnson TM, Hammond EM, Giaccia A, Attardi LD. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet 2005;37:145-52.
    • (2005) Nat Genet , vol.37 , pp. 145-152
    • Johnson, T.M.1    Hammond, E.M.2    Giaccia, A.3    Attardi, L.D.4
  • 8
    • 0037349289 scopus 로고    scopus 로고
    • p53 has a direct apoptogenic role at the mitochondria
    • Mihara M, Erster S, Zaika A, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003;11:577-90.
    • (2003) Mol Cell , vol.11 , pp. 577-590
    • Mihara, M.1    Erster, S.2    Zaika, A.3
  • 9
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004;303: 1010-4.
    • (2004) Science , vol.303 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3
  • 10
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-21.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 11
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks T, Remington L, Williams BO, et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994;4:1-7.
    • (1994) Curr Biol , vol.4 , pp. 1-7
    • Jacks, T.1    Remington, L.2    Williams, B.O.3
  • 12
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M. Decision making by p53: life, death and cancer. Cell Death Differ 2003;10:431-42.
    • (2003) Cell Death Differ , vol.10 , pp. 431-442
    • Oren, M.1
  • 13
    • 0037048323 scopus 로고    scopus 로고
    • Loss of p53 and centrosome hyperamplification
    • Tarapore P, Fukasawa K. Loss of p53 and centrosome hyperamplification. Oncogene 2002;21:6234-40.
    • (2002) Oncogene , vol.21 , pp. 6234-6240
    • Tarapore, P.1    Fukasawa, K.2
  • 14
  • 15
    • 18644375649 scopus 로고    scopus 로고
    • Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
    • Takai H, Naka K, Okada Y, et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 2002;21:5195-205.
    • (2002) EMBO J , vol.21 , pp. 5195-5205
    • Takai, H.1    Naka, K.2    Okada, Y.3
  • 16
    • 0036211857 scopus 로고    scopus 로고
    • p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene
    • Boley SE, Wong VA, French JE, Recio L. p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene. Toxicol Sci 2002;66:209-15.
    • (2002) Toxicol Sci , vol.66 , pp. 209-215
    • Boley, S.E.1    Wong, V.A.2    French, J.E.3    Recio, L.4
  • 17
    • 0024039889 scopus 로고
    • Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1
    • Reisman D, Greenberg M, Rotter V. Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1. Proc Natl Acad Sci U S A 1988;85:5146-50.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 5146-5150
    • Reisman, D.1    Greenberg, M.2    Rotter, V.3
  • 18
    • 0037372005 scopus 로고    scopus 로고
    • The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
    • Dumont P, Leu JI, Della PAC, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 2003;33:357-65.
    • (2003) Nat Genet , vol.33 , pp. 357-365
    • Dumont, P.1    Leu, J.I.2    Della, P.A.C.3    George, D.L.4    Murphy, M.5
  • 19
    • 24344448786 scopus 로고    scopus 로고
    • p53 isoforms can regulate p53 transcriptional activity
    • Bourdon JC, Fernandes K, Murray-Zmijewski F, et al. p53 isoforms can regulate p53 transcriptional activity. Genes Dev 2005;19:2122-37.
    • (2005) Genes Dev , vol.19 , pp. 2122-2137
    • Bourdon, J.C.1    Fernandes, K.2    Murray-Zmijewski, F.3
  • 20
    • 0037112844 scopus 로고    scopus 로고
    • "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally
    • Garcia-Cao I, Garcia-Cao M, Martin-Caballero J, et al. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J 2002;21:6225-35.
    • (2002) EMBO J , vol.21 , pp. 6225-6235
    • Garcia-Cao, I.1    Garcia-Cao, M.2    Martin-Caballero, J.3
  • 21
    • 0028168643 scopus 로고
    • p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
    • Kemp CJ, Wheldon T, Balmain A. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet 1994;8:66-9.
    • (1994) Nat Genet , vol.8 , pp. 66-69
    • Kemp, C.J.1    Wheldon, T.2    Balmain, A.3
  • 22
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993;362:847-9.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 23
    • 0036527761 scopus 로고    scopus 로고
    • Dissecting p53 tumor suppressor functions in vivo
    • Schmitt CA, Fridman JS, Yang M, et al. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 2002;1:289-98.
    • (2002) Cancer Cell , vol.1 , pp. 289-298
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3
  • 25
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303:844-8.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 26
    • 0035905749 scopus 로고    scopus 로고
    • Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: A new biomedical research tool
    • Luo JL, Yang Q, Tong WM, et al. Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool. Oncogene 2001;20:320-8.
    • (2001) Oncogene , vol.20 , pp. 320-328
    • Luo, J.L.1    Yang, Q.2    Tong, W.M.3
  • 27
    • 20244375365 scopus 로고    scopus 로고
    • UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin
    • Luo JL, Tong WM, Yoon JH, et al. UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin. Cancer Res 2001;61:8158-63.
    • (2001) Cancer Res , vol.61 , pp. 8158-8163
    • Luo, J.L.1    Tong, W.M.2    Yoon, J.H.3
  • 28
    • 1542327685 scopus 로고    scopus 로고
    • Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene
    • Liu Z, Hergenhahn M, Schmeiser HH, et al. Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene. Proc Natl Acad Sci U S A 2004;101:2963-8.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2963-2968
    • Liu, Z.1    Hergenhahn, M.2    Schmeiser, H.H.3
  • 29
    • 16844384191 scopus 로고    scopus 로고
    • p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors
    • Liu Z, Muehlbauer KR, Schmeiser HH, et al. p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. Cancer Res 2005;65:2583-7.
    • (2005) Cancer Res , vol.65 , pp. 2583-2587
    • Liu, Z.1    Muehlbauer, K.R.2    Schmeiser, H.H.3
  • 31
    • 0033119627 scopus 로고    scopus 로고
    • 20 of human p53 in the negative regulation of p53 by Mdm2
    • 20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J 1999;18:1805-14.
    • (1999) EMBO J , vol.18 , pp. 1805-1814
    • Unger, T.1    Juven-Gershon, T.2    Moallem, E.3
  • 32
    • 0033567340 scopus 로고    scopus 로고
    • 18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
    • 18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers. Biochem J 1999;342:133-41.
    • (1999) Biochem J , vol.342 , pp. 133-141
    • Craig, A.L.1    Burch, L.2    Vojtesek, B.3
  • 33
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A 1999;96:13777-82.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 34
    • 0037220737 scopus 로고    scopus 로고
    • mdm2 is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation
    • Mendrysa SM, McElwee MK, Michalowski J, et al. mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation. Mol Cell Biol 2003;23:462-72.
    • (2003) Mol Cell Biol , vol.23 , pp. 462-472
    • Mendrysa, S.M.1    McElwee, M.K.2    Michalowski, J.3
  • 35
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev 1993;7: 1126-32.
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 36
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003;4:321-8.
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3
  • 39
    • 0346455759 scopus 로고    scopus 로고
    • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
    • Liu G, Parant JM, Lang G, et al. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 2004;36:63-8.
    • (2004) Nat Genet , vol.36 , pp. 63-68
    • Liu, G.1    Parant, J.M.2    Lang, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.