Placental transfer of ondansetron during early human pregnancy

Clinical Pharmacokinetics

Volumn 45, Issue 4, 2006, Pages 419-423

  Siu, Shing Shun N ^a   Chan, Matthew T V ^a   Lau, Tze Kin ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ONDANSETRON;

ADULT; AMNION FLUID; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG SAFETY; DRUG TISSUE LEVEL; FEMALE; FETUS; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MULTIPLE DRUG DOSE; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL; PROSPECTIVE STUDY; VENOUS BLOOD;

ADULT; AMNIOTIC FLUID; ANTIEMETICS; BODY FLUIDS; FEMALE; FETUS; HUMANS; MATERNAL-FETAL EXCHANGE; MODELS, BIOLOGICAL; ONDANSETRON; PREGNANCY; PREGNANCY TRIMESTER, FIRST; SEROTONIN ANTAGONISTS;

EID: 33645511598     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200645040-00006     Document Type: Article

References (20)

1. Gadsby R, Barnie-Adshead AM, Jagger C. A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract 1993; 43: 245-8
2. Mazzotta P, Stewart DE, Koren G, et al. Factors associated with elective termination of pregnancy among Canadian and American women with nausea and vomiting of pregnancy. J Psychosom Obstet Gynaecol 2001; 22: 7-12
3. Broussard CN, Richter JE. Nausea and vomiting of pregnancy. Gastroenterol Clin North Am 1998; 27: 123-51
4. Magee LA, Mazzotta P, Koren G. Evidence-based view of safety and effectiveness of pharmacologic therapy for nausea and vomiting of pregnancy (NVP). Am J Obstet Gynecol 2002; 186: S256-61
5. Annas GJ, Elias S. Thalidomide and the titanic: reconstructing the technology tragedies of the twentieth century. Am J Public Health 1999; 89: 98-101
6. Koren G, Levichek Z. The teratogenicity of drugs for nausea and vomiting of pregnancy: perceived versus true risk. Am J Obstet Gynecol 2002; 186: S248-52
7. Wilde MI, Markham A. Ondansetron: a review of its pharmacology and preliminary clinical findings in novel applications. Drugs 1996; 52: 773-94
8. Guikontes E, Spantideas A, Diakakis J. Ondansetron and hyperemesis gravidarum. Lancet 1992; 340: 1223
9. World MJ. Ondansetron and hyperemesis gravidarum. Lancet 1993; 341: 185
10. Tincello DG, Johnstone MJ. Treatment of hyperemesis gravidarum with the 5-HT3 antagonist ondansetron (Zofran). Postgrad Med J 1996; 72: 688-9
11. Siu SSN, Yip SK, Cheung CW, et al. Treatment of intractable hyperemesis gravidarum by ondansetron. Eur J Obstet Gynecol Reprod Biol 2002; 105: 73-4
12. Siu SSN, Yeung JHK, Lau TK. A study on placental transfer of diclofenac in first trimester of human pregnancy. Hum Reprod 2000; 15: 2423-5
13. Sullivan CA, Johnson CA, Roach H, et al. A pilot study of intravenous ondansetron for hyperemesis gravidarum. Am J Obstet Gynecol 1996; 174: 1565-8
14. Einarson A, Maltepe C, Navioz Y, et al. The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study. BJOG 2004; 111: 940-3
15. Colthup PV, Palmer JL. The determination in plasma and pharmacokinetics of ondansetron. Eur J Cancer Clin Oncol 1989; 25 Suppl. 1: S71-4
16. Jauniaux E, Gulbis B. Fluid compartments of the embryonic environment. Hum Reprod Update 2000; 6: 268-78
17. Tucker ML, Jackson MR, Scales MDC, et al. Ondansetron: preclinical safety evaluation. Eur J Cancer Clin Oncol 1989; 25 Suppl. 1: S79-93
18. Klug S. Whole embryo culture: interpretation of abnormal development in vitro. Reprod Toxicol 1991; 5: 237-44
19. Garland M. Pharmacology of drug transfer across the placenta. Obstet Gynecol Clin North Am 1998; 25: 21-42
20. Siu SSN, Yeung JHK, Lau TK. An in-vivo study on placental transfer of naproxen in early human pregnancy. Hum Reprod 2002; 17: 1056-9