Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: A randomized controlled clinical trial

World Journal of Gastroenterology

Volumn 12, Issue 8, 2006, Pages 1265-1269

  Suzuki, Hideyuki ^a   Takagi, Hitoshi ^a   Sohara, Naondo ^a   Kanda, Daisuke ^a   Kakizaki, Satoru ^a   Sato, Ken ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

HCV; Interferon; Ribavirin; Zinc

Indexed keywords

PEGINTERFERON ALPHA2B; PLOMAC; POLAPREZINC; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN; VIRUS RNA;

ABDOMINAL DISCOMFORT; ADULT; AGED; ANEMIA; ANOREXIA; ARTHRALGIA; ARTICLE; CHRONIC HEPATITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG RESPONSE; ECZEMA; FATIGUE; FEMALE; FEVER; FLU LIKE SYNDROME; GENOTYPE; HAIR LOSS; HEADACHE; HEPATITIS C; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; PSYCHOSOMATIC DISORDER; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STOMATITIS; THROMBOCYTOPENIA; VIRUS LOAD;

EID: 33645506843     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i8.1265     Document Type: Article

References (21)

1. Di Bisceglie AM. Hepatitis C. Lancet 1998; 351: 351-355
2. Marcellin P. Hepatitis C: the clinical spectrum of the disease. J Hepatol 1999; 31 Suppl 1: 9-16
3. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-965
4. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Goncales FL Jr, Haussinger D, Diago M, Carosi G, Dhumeaux D, Craxi A, Lin A, Hoffman J, Yu J. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-982
5. Zeuzem S, Feinman SV, Rasenack J, Heathcote EJ, Lai MY, Gane E, O'Grady J, Reichen J, Diago M, Lin A, Hoffman J, Brunda MJ. Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med 2000; 343: 1666-1672
6. Loguercio C, De Girolamo V, Federico A, Feng SL, Cataldi V, Del Vecchio Blanco C, Gialanella G. Trace elements and chronic liver diseases. J Trace Elem Med Biol 1997, 11: 158-161
7. Aggett PJ. Severe zinc deficiency. In: Millis CF, ed. Zinc in Human Biology. New York: Springer-Verlag, 1989: 259-279
8. Umeta M, West CE, Haidar J, Deurenberg P, Hautvast JG. Zinc supplementation and stunted infants in Ethiopia: a randomised controlled trial. Lancet 2000; 355: 2021-2026
9. Haraguchi Y, Sakurai H, Hussain S, Anner BM, Hoshino H. Inhibition of HIV-1 infection by zinc group metal compounds. Antiviral Res 1999; 43: 123-133
10. Novick SG, Godfrey JC, Pollack RL, Wilder HR. Zinc-induced suppression of inflammation in the respiratory tract, caused by infection with human rhinovirus and other irritants. Med Hypotheses 1997; 49: 347-357
11. Kumel G, Schrader S, Zentgraf H, Brendel M. Therapy of banal HSV lesions: molecular mechanisms of the antiviral activity of zinc sulfate. Hautarzt 1991; 42: 439-445
12. Powell SR. The antioxidant properties of zinc. J Nutr 2000; 130: 1447S-1454S
13. Prasad AS. Zinc and immunity. Mol Cell Biochem 1998; 188: 63-69
14. Nagamine T, Takagi H, Takayama H, Kojima A, Kakizaki S, Mori M, Nakajima K. Preliminary study of combination therapy with interferon-alpha and zinc in chronic hepatitis C patients with genotype 1b. Biol Trace Elem Res 2000; 75: 53-63
15. Takagi H, Nagamine T, Abe T, Takayama H, Sato K, Otsuka T, Kakizaki S, Hashimoto Y, Matsumoto T, Kojima A, Takezawa J, Suzuki K, Sato S, Mori M. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat 2001; 8: 367-371
16. Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991; 13: 372-374
17. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 1513-1520
18. Nagamine T, Takagi H, Hashimoto Y, Takayama H, Shimoda R, Nomura N, Suzuki K, Mori M, Nakajima K. The possible role of zinc and metallothionein in the liver on the therapeutic effect of IFN-alpha to hepatitis C patients. Biol Trace Elem Res 1997; 58: 65-76
19. Arakawa T, Satoh H, Nakamura A, Nebiki H, Fukuda T, Sakuma H, Nakamura H, Ishikawa M, Seiki M, Kobayashi K. Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2. Dig Dis Sci 1990; 35: 559-566
20. Miyoshi A, Matsuo H, Miwa G, Nakajima M. Clinical evaluation of Z-103 in the treatment of gastric ulcer. Jpn Pharmacol Ther 1992; 20: 181-197
21. Furuta S, Toyama S, Miwa M, Ikeda Y, Sano H, Matsuda K. Study on the metabolic fate of catena-(S)-[mu-[N alpha-(3-aminopropionyl)histidinato(2-)-NI,N2,O:N tau]-zinc]. 4th communication: disposition of zinc and amino acids in rats, dogs and monkeys. Arzneimittelforschung 1991; 41: 965-975