메뉴 건너뛰기




Volumn 20, Issue 3, 2006, Pages 169-177

Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice

Author keywords

Antioxidant defense enzymes; Azadirachta indica; Biotransformation; Hepatic tissue injury; Oxidative stress; Skin tumors

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; AZADIRACHTA INDICA EXTRACT; CARCINOGEN; CYTOCHROME B5; CYTOCHROME P450; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIVER ENZYME; XENOBIOTIC AGENT;

EID: 33645473357     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.1782     Document Type: Article
Times cited : (37)

References (35)
  • 1
    • 0034048872 scopus 로고    scopus 로고
    • Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats
    • Arivazhagan S, Balasenthil S, Nagini S. 2000. Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats. Phytother Res 14: 291-293.
    • (2000) Phytother Res , vol.14 , pp. 291-293
    • Arivazhagan, S.1    Balasenthil, S.2    Nagini, S.3
  • 2
    • 4644352351 scopus 로고    scopus 로고
    • Effect of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinogenesis
    • Arivazhagan S, Velmurugan B, Bhuvaneswari V, Nagini S. 2004. Effect of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinogenesis. J Med Food 7: 334-339.
    • (2004) J Med Food , vol.7 , pp. 334-339
    • Arivazhagan, S.1    Velmurugan, B.2    Bhuvaneswari, V.3    Nagini, S.4
  • 3
    • 0346074656 scopus 로고    scopus 로고
    • Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underling mechanisms
    • Aziz MH, Kumar R, Ahmad N. 2003. Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underling mechanisms. Int J Oncol 23: 17-28.
    • (2003) Int J Oncol , vol.23 , pp. 17-28
    • Aziz, M.H.1    Kumar, R.2    Ahmad, N.3
  • 4
    • 0032851388 scopus 로고    scopus 로고
    • Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz [a] anthracene (DMBA) induced hamster buccal pouch carcinogenesis
    • Balasenthil S, Arivazhagan S, Ramachandran CR, Ramachandran V, Nagini S. 1999. Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz [a] anthracene (DMBA) induced hamster buccal pouch carcinogenesis. J Ethnopharmacol 67: 189-195.
    • (1999) J Ethnopharmacol , vol.67 , pp. 189-195
    • Balasenthil, S.1    Arivazhagan, S.2    Ramachandran, C.R.3    Ramachandran, V.4    Nagini, S.5
  • 6
    • 0033960418 scopus 로고    scopus 로고
    • Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats
    • Bhanwra S, Singh J, Khosla P. 2000. Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats. Indian J Physiol Pharmacol 44: 64-68.
    • (2000) Indian J Physiol Pharmacol , vol.44 , pp. 64-68
    • Bhanwra, S.1    Singh, J.2    Khosla, P.3
  • 7
    • 0002925047 scopus 로고    scopus 로고
    • Biological activities and medicinal properties of neem (Azadirachta indica)
    • Biswas K, Chattopadhyay I, Banerjee RK, Bandopadhyay U. 2002. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 82: 1336-1345.
    • (2002) Curr Sci , vol.82 , pp. 1336-1345
    • Biswas, K.1    Chattopadhyay, I.2    Banerjee, R.K.3    Bandopadhyay, U.4
  • 8
    • 0016808562 scopus 로고
    • Purification and characterization of the flavo enzyme glutathione reductase from rat liver
    • Carlberg I, Mannervik B. 1975. Purification and characterization of the flavo enzyme glutathione reductase from rat liver. J Biol Chem 250: 5475-5480.
    • (1975) J Biol Chem , vol.250 , pp. 5475-5480
    • Carlberg, I.1    Mannervik, B.2
  • 9
    • 1942424089 scopus 로고    scopus 로고
    • Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems
    • Dasgupta T, Banerjee S, Yadava PK, Rao AR. 2004. Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems. J Ethnopharmacol 92: 23-36.
    • (2004) J Ethnopharmacol , vol.92 , pp. 23-36
    • Dasgupta, T.1    Banerjee, S.2    Yadava, P.K.3    Rao, A.R.4
  • 10
    • 0036417442 scopus 로고    scopus 로고
    • Bis-1,72-hydroxyphenyl-hepta-1,6-diene-3, dione (a curcumin analog) ameliorates DMH-induced hepatic oxidative stress during colon carcinogenesis
    • Devasena T, Rajasekaran KN, Menon VP. 2002. Bis-1,7(2-hydroxyphenyl- hepta-1,6-diene-3, dione (a curcumin analog) ameliorates DMH-induced hepatic oxidative stress during colon carcinogenesis. Pharmacol Res 46: 39-45.
    • (2002) Pharmacol Res , vol.46 , pp. 39-45
    • Devasena, T.1    Rajasekaran, K.N.2    Menon, V.P.3
  • 11
    • 0025819973 scopus 로고
    • Effect of alpha-tocopherol on doxrubicin-induced changes in rat liver and heart microsomes
    • Geetha A, Marar T, Devi CSS. 1991. Effect of alpha-tocopherol on doxrubicin-induced changes in rat liver and heart microsomes. Indian J Exp Biol 29: 782-785.
    • (1991) Indian J Exp Biol , vol.29 , pp. 782-785
    • Geetha, A.1    Marar, T.2    Devi, C.S.S.3
  • 12
    • 0023951396 scopus 로고
    • Roles of cytochrome p-450 enzymes in chemical carcinogenesis and cancer chemotherapy
    • Guengerich FP. 1988. Roles of cytochrome p-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res 48: 2946-2954.
    • (1988) Cancer Res , vol.48 , pp. 2946-2954
    • Guengerich, F.P.1
  • 13
    • 0022172446 scopus 로고
    • Trace element profiles in skin-tumor and tissues of tumor-bearing mice
    • Gulati N, Mangal PC. 1985. Trace element profiles in skin-tumor and tissues of tumor-bearing mice. Indian J Cancer 22: 308-314.
    • (1985) Indian J Cancer , vol.22 , pp. 308-314
    • Gulati, N.1    Mangal, P.C.2
  • 14
    • 0016275313 scopus 로고
    • Glutathione-S-transferase: The first enzymatic step in mercapturic acid formation
    • Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione-S-transferase: The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 15
    • 0024365674 scopus 로고
    • Implications for therapy of drug-metabolizing enzymes in human colon cancer
    • Ishak MK, Hudson N, Tsao MS, Batist G. 1989. Implications for therapy of drug-metabolizing enzymes in human colon cancer. Cancer Res 49: 4866-4869.
    • (1989) Cancer Res , vol.49 , pp. 4866-4869
    • Ishak, M.K.1    Hudson, N.2    Tsao, M.S.3    Batist, G.4
  • 16
    • 0043134971 scopus 로고    scopus 로고
    • Effect of Sapthaparna (Alstonia scholaris Linn) in modulating the benzo(a)pyrene-induced forestomach carcinogenesis in mice
    • Jagetia GC, Baliga MS, Venkatesh P. 2003. Effect of Sapthaparna (Alstonia scholaris Linn) in modulating the benzo(a)pyrene-induced forestomach carcinogenesis in mice. Toxicol Lett 144: 183-193.
    • (2003) Toxicol Lett , vol.144 , pp. 183-193
    • Jagetia, G.C.1    Baliga, M.S.2    Venkatesh, P.3
  • 17
    • 0036304007 scopus 로고    scopus 로고
    • Chemoprevention of bladder cancer
    • Kamat AM, Lamm DL. 2002. Chemoprevention of bladder cancer. Urol Clin N Am 29: 157-168.
    • (2002) Urol Clin N Am , vol.29 , pp. 157-168
    • Kamat, A.M.1    Lamm, D.L.2
  • 18
    • 0032101097 scopus 로고    scopus 로고
    • Effects of neem flowers. Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic mono-oxygenases and glutathione S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats
    • Kusamran WR, Ratanavila A, Tepsuwan A. 1998. Effects of neem flowers. Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic mono-oxygenases and glutathione S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats. Food Chem Toxicol 36: 475-484.
    • (1998) Food Chem Toxicol , vol.36 , pp. 475-484
    • Kusamran, W.R.1    Ratanavila, A.2    Tepsuwan, A.3
  • 20
    • 0026464753 scopus 로고
    • Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems
    • Massaad L, Waziers I, Chabot G. 1992. Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems. Cancer Res 52: 6567-6575.
    • (1992) Cancer Res , vol.52 , pp. 6567-6575
    • Massaad, L.1    Waziers, I.2    Chabot, G.3
  • 21
    • 3042542939 scopus 로고    scopus 로고
    • Treatment of cancer with mushroom products
    • Monro JA. 2003. Treatment of cancer with mushroom products. Arch Environ Health 58: 533-537.
    • (2003) Arch Environ Health , vol.58 , pp. 533-537
    • Monro, J.A.1
  • 22
    • 0036085164 scopus 로고    scopus 로고
    • Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks
    • Moran EM. 2002. Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks. J Environ Pathol Toxicol Oncol 21: 193-201.
    • (2002) J Environ Pathol Toxicol Oncol , vol.21 , pp. 193-201
    • Moran, E.M.1
  • 23
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
    • Moron MS, Depierre JW, Mannervik B. 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 582: 67-78.
    • (1979) Biochim Biophys Acta , vol.582 , pp. 67-78
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3
  • 24
    • 7744243701 scopus 로고    scopus 로고
    • Prolonged cytotoxic effect of colchicine released from biodegradable microspheres
    • Muvaffak A, Gurhan I, Hasirci N. 2004. Prolonged cytotoxic effect of colchicine released from biodegradable microspheres. J Biomed Mat Res 71: 295-304.
    • (2004) J Biomed Mat Res , vol.71 , pp. 295-304
    • Muvaffak, A.1    Gurhan, I.2    Hasirci, N.3
  • 25
    • 78651165715 scopus 로고
    • The carbon mono-oxide binding pigment of liver microsomes. I Evidence for its haemoprotein nature
    • Omura J, Sato R. 1964a. The carbon mono-oxide binding pigment of liver microsomes. I Evidence for its haemoprotein nature. J Biol Chem 239: 2370-2378.
    • (1964) J Biol Chem , vol.239 , pp. 2370-2378
    • Omura, J.1    Sato, R.2
  • 26
    • 50449100139 scopus 로고
    • The carbon mono-oxide binding pigment of liver microsomes. II Solubilisation purification and properties
    • Omura J, Sato R. 1964b. The carbon mono-oxide binding pigment of liver microsomes. II Solubilisation purification and properties. J Biol Chem 239: 2379-2385.
    • (1964) J Biol Chem , vol.239 , pp. 2379-2385
    • Omura, J.1    Sato, R.2
  • 27
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169.
    • (1967) J Lab Clin Med , vol.70 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 28
    • 66349129125 scopus 로고
    • A colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic trans-aminase
    • Reitman S, Frankel SA. 1957. A colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic trans-aminase. Am J Clin Pathol 28: 56-63.
    • (1957) Am J Clin Pathol , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.A.2
  • 29
    • 0024391060 scopus 로고
    • Cancer chemoprevention by supplemental carotenoids in animals and humans
    • Santamaria L, Bianchi A. 1989. Cancer chemoprevention by supplemental carotenoids in animals and humans. Prev Med 18: 603-623.
    • (1989) Prev Med , vol.18 , pp. 603-623
    • Santamaria, L.1    Bianchi, A.2
  • 30
    • 0022303066 scopus 로고
    • Drug reactions with herbal drugs
    • Saxena RC. 1985. Drug reactions with herbal drugs. Indian J Pharmacol 77: 165-169.
    • (1985) Indian J Pharmacol , vol.77 , pp. 165-169
    • Saxena, R.C.1
  • 31
    • 0033812693 scopus 로고    scopus 로고
    • Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice
    • Sharma N, Trikha P, Athar M, Raisuddin S. 2000. Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice. Hum Exp Toxicol 19: 377-384.
    • (2000) Hum Exp Toxicol , vol.19 , pp. 377-384
    • Sharma, N.1    Trikha, P.2    Athar, M.3    Raisuddin, S.4
  • 33
    • 0642371429 scopus 로고    scopus 로고
    • Ethanolic neem leaf extract protects against N-methyl-N-nitro-N- nitrosoguanidine induced gastric carcinogenesis
    • Subapriya R, Nagini S. 2003. Ethanolic neem leaf extract protects against N-methyl-N-nitro-N-nitrosoguanidine induced gastric carcinogenesis. Asian Pacific J Cancer Prev 4: 215-223.
    • (2003) Asian Pacific J Cancer Prev , vol.4 , pp. 215-223
    • Subapriya, R.1    Nagini, S.2
  • 34
    • 0019465745 scopus 로고
    • In vitro stimulation by araquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes
    • Trush MA, Mimnaugh EG, Ginsburg E, Gram TE. 1981. In vitro stimulation by araquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes. Toxicol Appl Pharmacol 60: 279-286.
    • (1981) Toxicol Appl Pharmacol , vol.60 , pp. 279-286
    • Trush, M.A.1    Mimnaugh, E.G.2    Ginsburg, E.3    Gram, T.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.