Sequence of and regional difference in apoptotic index in the mouse gastrointestinal mucous epithelia after T-2 toxin inoculation

Journal of Toxicologic Pathology

Volumn 13, Issue 3, 2000, Pages 193-196

  Quiroga, Alejandra M ^a   Risso, M A ^a   Perfumo, Carlos J ^a   Idiart, Julio R ^a   Ohtsuka, Ryoichi ^b   Doi, Kunio ^b  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptotic index; Gastrointestine; Mitotic index; Mouse; T 2 toxin

Indexed keywords

EID: 33645471648     PISSN: 09149198     EISSN: 09149198     Source Type: Journal    
DOI: 10.1293/tox.13.193     Document Type: Article

References (15)

1. I ARC. Some naturally occurring substances: Food items and constituents, heterocyclic aromatic amines and mycotoxins. In : I ARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Lyon, 467-488, 1993.
2. Ueno Y. Trichothecene mycotoxins. In : Mycology, Chemistry and Toxicology (Draper HH ed.), New York : Plenum Publishing Co., 301-353, 1980.
3. Albarenque SM, Shinozuka J, Iwamoto S, Nakayama H, and Doi K. T-2 toxin-induced acute skin lesions in Wistarderived hypotrichotic WBN/ILA-Ht rats. Histol Histopathol 1999; 14: 337-342.
4. Deloach JR, Gyongyossy-Issa MIC, and Khachatouriants GG. Species-specific hemolysis of erythrocytes by T-2 toxin.Toxicol Appl Pharmacol 1989; 97: 107-112.
5. Friend SC, Hancock DS, Schiefer HB, and Babiuk LA. Experimental T-2 toxicosis in sheep. Can J Comp Med 1983 ; 47: 291-297.
6. Pang VF, Lorenzana RM, Beasley Vr, Buck WB, and Hascheck WM. Experimental T-2 toxicosis in swine. III. Morphologic changes following intravascular administration of T2 toxin. Fund Appl Toxicol 1987; 8: 298-309.
7. Quiroga MA, Itagaki S, and Doi K. Early ultrastructural changes of thymocytes in T-2 toxin intoxicated mice. J Toxicol Pathol 1993; 6: 109-112.
8. Williams PP. Effects of T-2 mycotoxin on gastrointestinal tissues : A review of in vivo and in vitro models. Arch Environ Contam Toxicol 1989; 18: 374-387.
9. Shinozuka J, Li GM, Uetsuka K, Nakayama H, and Doi K. Process of the development of T-2 toxin-induced apoptosis in the lymphoid organs of mice. Exp Anim 1997 ; 46 : 117-126.
10. Shinozuk J, Suzuki M, Noguchi N, Sugimoto T, Uetsuka K, Nakayama H, and Doi K. T-2 toxin-induced apoptosis in hematopoietic tissues in mice. Toxicol Pathol 1998; 26: 674-681.
11. Shinozuka J, Tsutsui S, Ishigami N, Ueno-Yamanouchi A, Nakayama H, and Doi K. Development of apoptosis and changes in apoptosis-related genes expression in the mouse thymus following T-2 toxin-inoculation. J Toxicol Pathol 1999; 12: 77-81.
12. Li GM, Shinozuka J, Uetsuka K, Nakayama H, and Doi K. T-2 toxin-induced apoptosis in intestinal crypt epithelial cells of mice. Exp Toxicol Pathol 1997 ; 49 : 447-450.
13. Coddington KA, Swanson SP, Hassan AS, and Buck WB. Enterohepatic circulation of T-2 toxin metabolites in the rat. Drug Metabol Disposit 1989; 17: 600-605.
14. Ueno Y. Mode of action of trichothecenes. Ann Nutr Alim 1977 ; 31: 885-900.
15. Rosenstein Y, and Lafarge FC. Inhibitory effect of Fusarium T-2 toxin on lymphoid DNA and protein synthesis. Toxicol Appl Pharmacol 1983 ; 70 : 283-288.