Role of EDTA chelation therapy in cardiovascular diseases

National Medical Journal of India

Volumn 19, Issue 1, 2006, Pages 24-26

  Shrihari, J S ^a   Roy, A ^a   Prabhakaran, D ^a   Reddy, K Srinath ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EDETIC ACID; VITAMIN;

ANTIOXIDANT ACTIVITY; ARTERIOSCLEROSIS; ARTERY DISEASE; AUTOIMMUNE DISEASE; BLEEDING; BONE MARROW DEPRESSION; CARDIOVASCULAR DISEASE; CHELATION THERAPY; CLINICAL TRIAL; CONVULSION; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG MEGADOSE; DRUG SAFETY; HEART ARRHYTHMIA; HUMAN; HYPOCALCEMIA; HYPOGLYCEMIA; HYPOTENSION; INTERMETHOD COMPARISON; ISCHEMIC HEART DISEASE; KIDNEY INJURY; MEDLINE; NAUSEA; RESPIRATORY ARREST; REVIEW; RISK BENEFIT ANALYSIS; SYSTEMATIC REVIEW; TETANUS; VOMITING;

ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; CHELATING AGENTS; EDETIC ACID; EVIDENCE-BASED MEDICINE; HUMANS; META-ANALYSIS; REPRODUCIBILITY OF RESULTS; TREATMENT OUTCOME;

EID: 33645468677     PISSN: 0970258X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (21)

1. Ernst E. Chelation therapy for peripheral arterial occlusive disease: A systematic review. Circulation 1997;96:1031-3.
2. Babu AN, Gonzalez-Pena H. Iron chelating agents are not useful in treating atherosclerosis. Ann Intern Med 1994;121:384-5.
3. Quan H, Ghali WA, Verhoef MJ, Norris CM, Galbraith PD, Knudtson ML. Use of chelation therapy after coronary angiography. Am J Med 2001;111:686-91.
4. The NIH Trial of EDTA Chelation Therapy for Coronary Artery Disease. National Center for Complementary and Alternative Medicine, National Institutes of Health (NIH), USA. Available at http://nccam.nih.gov/news/2002/chelation/q-and-a.htm#3 (accessed on 25 July 2005)
5. Ernst E. Chelation therapy for coronary heart disease: An overview of all clinical investigations. Am Heart J 2000;140:139-41.
6. Magee R. Chelation treatment of atherosclerosis. Med J Aust 1985;142:514-15.
7. McGillem MJ, Mancini GB. Inefficacy of EDTA chelation therapy for coronary atherosclerosis. N Engl J Med 1988;318:1618-19.
8. Grebe HB, Gregory PJ. Inhibition of warfarin anticoagulation associated with chelation therapy. Pharmacotherapy 2002;22:1067-9.
9. Wirebaugh SR, Geraets DR. Apparent failure of edetic acid chelation therapy for the treatment of coronary atherosclerosis. DICP 1990;24:22-5.
10. Green DJ, O'Driscoll JG, Maiorana A, Scrimgeour NB, Weerasooriya R, Taylor RR. Effects of chelation with EDTA and vitamin B therapy on nitric oxide-related endothelial vasodilator function. Clin Exp Pharmacol Physiol 1999;26:853-6.
11. Olszewer E, Carter JP. EDTA chelation therapy in chronic degenerative disease. Med Hypotheses 1988;27:41-9.
12. American Heart Association. Questions and answers about chelation therapy. Available at http://www.americanheart.org/presenter.jhtml?identifier=3000843 (accessed on 25 July 2005)
13. Villarruz MV, Dans A, Tan F. Chelation therapy for atherosclerotic cardiovascular disease. Cochrane Database Syst Rev 2002;CD002785.
14. Kitchell JR, Palmon F Jr, Aytan N, Meltzer LE. The treatment of coronary artery disease with disodium EDTA. A reappraisal. Am J Cardiol 1963;11:501-6.
15. Knudtson ML, Wyse DG, Galbraith PD, Brant R, Hildebrand K, Paterson D, et al. Chelation therapy for ischemic heart disease: A randomized controlled trial. JAMA 2002;287:481-6.
16. Anderson TJ, Hubacek J, Wyse DG, Knudtson ML. Effect of chelation therapy on endothelial function inpatients with coronary artery disease: PATCH substudy. J Am Coll Cardiol 2003;41:420-5.
17. Olszewer E, Sabbag FC, Carter JP. A pilot double-blind study of sodium-magnesium EDTA in peripheral vascular disease. J Natl Med Assoc 1990;82:173-7.
18. Sloth-Nielsen J, Guldager B, Mouritzen C, Lund EB, Egeblad M, Norregaard O et al. Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis. Am J Surg 1991;162:122-5.
19. Guldager B, Jelnes R, Jorgensen SJ, Nielsen JS, Klaerke A, Mogensen K, et al. EDTA treatment of intermittent claudication - A double-blind, placebo-controlled study. J Intern Med 1992;231:261-7.
20. van Rij AM, Solomon C, Packer SG, Hopkins WG. Chelation therapy for intermittent claudication: A double-blind, randomized, controlled trial. Circulation 1994;90: 1194-9.
21. Haskell WL, Luskin FM, Marvasti FF. Complementary and alternative therapies for cardiovascular disease. In: Spencer JW, Jacobs JJ (eds). Complementary/alternative medicine: An evidence based approach. Philadelphia:Mosby Yearbooks; 1999:94.