Ciliary function and the role of cilia in clearance

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 19, Issue 1, 2006, Pages 110-115

  Stannard, Wendy ^a   O'Callaghan, Chris ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Bronchiectasis; Cilia; Primary ciliary dyskinesia

Indexed keywords

TOXIN;

BACTERIAL INFECTION; BRONCHIECTASIS; CILIARY DYSKINESIA; CILIARY MOTILITY; CILIATED EPITHELIUM; CYSTIC FIBROSIS; ENVIRONMENTAL EXPOSURE; HOST RESISTANCE; HUMAN; INHALATION; LUNG; LUNG FIBROSIS; MUCOCILIARY CLEARANCE; MUCUS; NOSE; PARTICULATE MATTER; REVIEW; VIRUS INFECTION;

CILIA; CILIARY MOTILITY DISORDERS; HUMANS; MUCOCILIARY CLEARANCE; MUCUS; RESPIRATORY TRACT DISEASES;

EID: 33645464522     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2006.19.110     Document Type: Review

References (67)

1. Knowles, M.R., and R.C. Boucher. 2002. Mucus clearance as a primary innate defense mechanism for mammalian airways. J. Clin. Invest. 109:571-577.
2. Widdicombe, J.H. 2002. Regulation of the depth and composition of airway surface liquid. J. Anat. 201: 313-318.
3. Nettesheim, P., J.S. Koo, and T. Gray. 2000. Regulation of differentiation of the tracheobronchial epithelium. J. Aerosol. Med. 13:207-218.
4. Serafini, S.M., and E.D. Michaelson. 1977. Length and distribution of cilia in human and canine airways. Bull. Eur. Physiopathol. Respir. 13:551-559.
5. Sleigh, M.A. 1981. Ciliary function in mucus transport. Chest 80:791-795.
6. Weibel, E.R. 1979. Morphometry of the human lung: the state of the art after two decades. Bull. Eur. Physiopathol. Respir. 15:999-1013.
7. Boysen, M. 1982. The surface structure of the human nasal mucosa. I. Ciliated and metaplastic epithelium in normal individuals. A correlated study by scanning/transmission electron and light microscopy. Virchows Arch. B 40:279-294.
8. Sleigh, M.A., J.R. Blake, and N. Liron. 1988. The propulsion of mucus by cilia. Am. Rev. Respir. Dis. 137:726-741.
9. Ostrowski, L.E., K. Blackburn, K.M. Radde, et al. 2002. A proteomic analysis of human cilia: identification of novel components. Mol. Cell. Proteomics 1:451-465.
10. Wanner, A., M. Salathe, and T.G. O'Riordan. 1996. Mucociliary clearance in the airways. Am. J. Respir. Crit. Care Med. 154:1868-1902.
11. Satir, P., and T. Matsuoka. 1989. Splitting the ciliary axoneme: implications for a "switch-point" model of dynein arm activity in ciliary motion. Cell. Motil. Cytoskeleton 14:345-358.
12. Chilvers, M.A., and C. O'Callaghan. 2000. Analysis of ciliary beat pattern and beat frequency using digital high speed imaging: comparison with the photomultiplier and photodiode methods. Thorax 55:314-317.
13. Chilvers, M.A., A. Rutman, and C. O'Callaghan. 2003. Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia. J. Allergy Clin. Immunol 112:518-524.
14. Chilvers, M.A., A. Rutman, and C. O'Callaghan. 2003. Functional analysis of cilia and ciliated epithelial ultrastructure in healthy children and young adults. Thorax 58:333-338.
15. Matsui, H., S.H. Randell, S.W. Peretti, et al. 1998. Coordinated clearance of periciliary liquid and mucus from airway surfaces. J. Clin. Invest. 102:1125-1131.
16. Sackner, M.A., M.J. Rosen, and A. Wanner. 1973. Estimation of tracheal mucous velocity by bronchofiberscopy. J. Appl Physiol. 34:495-499.
17. Serafini, S.M., A. Wanner, and E.D. Michaelson. 1976. Mucociliary transport in central and intermediate size airways: effect of aminophyllin. Bull. Eur. Physiopathol. Respir. 12:415-422.
18. Iravani, J. 1975. Location-dependent activity of the ciliary movement in the bronchial tree and its possible mechanism. Arch. Pharmakon. 32:248.
19. Asmundsson, T., and K. Kilburn. 1973. Mechanisms of respiratory tract clearance. In Sputum: Fundamentals and Clinical Pathology. M. Dulfano, ed. Springfield: Charles C. Thomas, 107-180.
20. Foster, W.M., E. Langenback, and E.H. Bergofsky, 1980. Measurement of tracheal and bronchial mucus velocities in man: relation to lung clearance. J. Appl. Physiol. 48:965-971.
21. Lucas, A. 1932. Ciliated epithelium. In Special Cytology. E.V. Cowdry, ed. New York: Paul B. Hoeber, 409-474.
22. Schurch, S., P. Gehr, V. Im Hof, et al. 1990. Surfactant displaces particles toward the epithelium in airways and alveoli. Respir. Physiol. 80:17-32.
23. Tarran, R., B.R. Grubb, J.T. Gatzy, et al. 2001. The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J. Gen. Physiol 118:223-236.
24. Sturgess, J.M., M.W. Thompson, E. Czegledy-Nagy, et al. 1986. Genetic aspects of immotile cilia syndrome. Am. J. Med. Genet. 25:149-160.
25. Schidlow, D.V. 1994. Primary ciliary dyskinesia (the immotile cilia syndrome). Ann. Allergy 73:457-470.
26. Camner, P., B. Mossberg, and B.A. Afzelius. 1983. Measurements of tracheobronchial clearance in patients with immotile-cilia syndrome and its value in differential diagnosis. Eur. J. Respir. Dis. Suppl. 127:57-63.
27. Afzelius, B.A., B. Mossberg, and S. Bergstrom. 2001. Immotile cilia syndrome (primary ciliary dyskinesia), including Kartagener syndrome. In The metabolic and molecular bases of inherited disease. C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds. New York: McGraw Hill, 4817-4827.
28. Coren, M.E., M. Meeks, I. Morrison, et al. 2002. Primary ciliary dyskinesia: age at diagnosis and symptom history. Acta Paediatr. 91:667-669.
29. Bush, A., P. Cole, M. Hariri, et al. 1998. Primary ciliary dyskinesia: diagnosis and standards of care. Eur. Respir. J. 12:982-988.
30. Stannard, W., A. Rutman, C. Wallis, et al. 2004. Central microtubular agenesis causing primary ciliary dyskinesia. Am. J. Respir. Crit. Care Med. 169:634-637.
31. Ellerman, A., and H. Bisgaard. 1997. Longitudinal study of lung function in a cohort of primary ciliary dyskinesia. Eur. Respir. J. 10:2376-2379.
32. Hadfield, P.J., J.M. Rowe-Jones, A. Bush, et al. 1997. Treatment of otitis media with effusion in children with primary ciliary dyskinesia. Clin. Otolaryngol. Allied Sci. 22:302-306.
33. Munro, N.C., D.C. Currie, KS. Lindsay, et al. 1994. Fertility in men with primary ciliary dyskinesia presenting with respiratory infection. Thorax 49:684-687.
34. Afzelius, B.A. 1983. Ultrastructural basis for ciliary motility. Eur. J. Respir. Dis. Suppl. 128:280-286.
35. Rossman, C.M., and M.T. Newhouse. 1988. Primary ciliary dyskinesia: evaluation and management. Pediatr. Pulmonol. 5:36-50.
36. Noone, P.G., M.W. Leigh, A. Sannuti, et al. 2004. Primary ciliary dyskinesia: diagnostic and phenotypic features. Am. J. Respir. Crit. Care Med. 169:459-467.
37. Jorissen, M., T. Willems, B. Van der Schueren, et al. 2000. Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in culture. Acta Otorhinolaryngol. Belg. 54:343-356.
38. Wodehouse, T., S.A. Kharitonov, I.S. Mackay, et al. 2003. Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia. Eur. Respir. J. 21:43-47.
39. Lundberg, J.O., E. Weitzberg, S.L. Nordvall, et al. 1994. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur. Respir. J. 7:1501-1504.
40. Narang, L, R. Ersu, N.M. Wilson, et al. 2002. Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance. Thorax 57:586-589.
41. Blouin, J.L., M. Meeks, U. Radhakrishna, et al. 2000. Primary ciliary dyskinesia: a genome-wide linkage analysis reveals extensive locus heterogeneity. Eur. J. Hum. Genet. 8:109-118.
42. Geremek, M., and M. Witt. 2004. Primary ciliary dyskinesia: genes, candidate genes and chromosomal regions. J. Appl Genet. 45:347-361.
43. Zariwala, M., W.K. O'Neal, P.G. Noone, et al. 2004. Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia. Am. J. Respir. Cell. Mol. Biol. 30:428-434.
44. Zariwala, M., P.G. Noone, A. Sannuti, et al. 2001. Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia. Am. J. Respir. Cell. Mol Biol 25:577-583.
45. Olbrich, H., K. Haffner, A. Kispert, et al. 2002. Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Nat. Genet. 30:143-144.
46. Pennarun, G., E. Escudier, C. Chapelin, et al. 1999. Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia. Am. J. Hum. Genet. 65: 1508-1519.
47. Pedersen, M., Y. Sakakura, B. Winther, et al. 1983. Nasal mucociliary transport, number of ciliated cells, and beating pattern in naturally acquired common colds. Eur. J. Respir. Dis. Suppl. 128:355-365.
48. Wilson, R., E. Alton, A. Rutman, et al. 1987. Upper respiratory bract viral infection and mucociliary clearance. Eur. J. Respir. Dis. 70:272-279.
49. Chilvers, M.A., M. McKean, A. Rutman, et al. 2001. The effects of coronavirus on human nasal ciliated respiratory epithelium. Eur. Respir. J. 18:965-970.
50. Carson, J.L., A.M. Collier, and S.S. Hu. 1985. Acquired ciliary defects in nasal epithelium of children with acute viral upper respiratory infections. N. Engl. J. Med. 312:463-468.
51. Rautiainen, M., J. Nuutinen, H. Kiukaanniemi, et al. 1992. Ultrastructural changes in human nasal cilia caused by the common cold and recovery of ciliated epithelium. Ann. Otol. Rhinol. Laryngol. 101:982-987.
52. Tsang, K.W., A. Rutman, K. Kanthakumar, et al. 1993. Haemophilus influenzae infection of human respiratory mucosa in low concentrations of antibiotics. Am. Rev. Respir. Dis. 148:201-207.
53. Wilson, R., R. Read, and P. Cole. 1992. Interaction of Haemophilus influenzae with mucus, cilia, and respiratory epithelium. J. Infect. Dis. 165:S100-S102.
54. Feldman, C., R. Read, A. Rutman, et al. 1992. The interaction of Streptococcus pneumoniae with intact human respiratory mucosa in vitro. Eur. Respir. J. 5:576-583.
55. Rayner, C.F., A. Rutman, A. Dewar, et al. 1995. Ciliary disorientation in patients with chronic upper respiratory tract inflammation. Am. J. Respir. Crit. Care Med. 151:800-804.
56. Wilson, R., T. Pitt, G. Taylor, et al. 1987. Pyocyanin and L-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. J. Clin. Invest. 79:221-229.
57. Currie, D.C., D. Pavia, J.E. Agnew, et al. 1987. Impaired tracheobronchial clearance in bronchiectasis. Thorax 42:126-130.
58. Svartengren, M., B. Mossberg, K. Philipson, et al. 1986. Mucociliary clearance in relation to clinical features in patients with bronchiectasis. Eur. J. Respir. Dis. 68:267-278.
59. Isawa, T., T. Teshima, T. Hirano, et al. 1990. Mucociliary clearance and transport in bronchiectasis: global and regional assessment. J. Nucl. Med. 31:543-548.
60. Rutland, J., W. Griffin, and P. Cole. 1981. Nasal brushing and measurement of ciliary beat frequency. An in vitro method for evaluating pharmacologic effects on human cilia. Chest 80:865-867.
61. de Iongh, R.U., and J. Rutland. 1995. Ciliary defects in healthy subjects, bronchiectasis, and primary ciliary dyskinesia. Am. J. Respir. Crit. Care Med. 151: 1559-1567.
62. Konrad, F., R. Schiener, T. Marx, et al. 1995. Ultrastructure and mucociliary transport of bronchial respiratory epithelium in intubated patients. Intens. Care Med. 21:482-489.
63. Sackner, M.A., J.F. Landa, N. Greeneltch, et al. 1973. Pathogenesis and prevention of tracheobronchial damage with suction procedures. Chest 64:284-290.
64. Giordano, A., and D.S. Holsclaw. 1976. Tracheal resection and mucociliary clearance. Ann. Otol. Rhinol. Laryngol. 85:631-639.
65. Toomes, H., and A. Linder. 1989. Mucociliary clearance following tracheal resection and end-to-end anastomosis. Thorac. Cardiovasc. Surg. 37:277-280.
66. Herve, P., D. Silbert, J. Cerrina, et al. 1993. Impairment of bronchial mucociliary clearance in long-term survivors of heart/lung and double-lung transplantation. The Paris-Sud Lung Transplant Group. Chest 103:59-63.
67. Houtmeyers, E., R. Gosselink, G. Gayan-Ramirez, et al. 1999. Regulation of mucociliary clearance in health and disease. Eur. Respir. J. 13:1177-1188.