How useful is (123I) β-CIT SPECT in the diagnosis of Parkinson's disease?

Reviews in Neurological Diseases

Volumn 3, Issue 1, 2006, Pages 19-22

  Bhidayasiri, Roongroj ^a,b  

^a UCLA MEDICAL CENTER   (United States)

^b KING CHULALONGKORN MEMORIAL HOSPITAL   (Thailand)

Author keywords

Atypical parkinsonian syndromes; Dopamine transporter; Essential tremor; Parkinson's disease; Single photon emission computed tomography

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; BIOLOGICAL MARKER; IODINE 123; COCAINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT;

ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; HUMAN; IN VIVO STUDY; NERVE ENDING; PARKINSON DISEASE; PARKINSONISM; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRIATONIGRAL DEGENERATION; BRAIN; ESSENTIAL TREMOR; METABOLISM; METHODOLOGY; REVIEW; SCINTISCANNING;

BRAIN; COCAINE; ESSENTIAL TREMOR; HUMANS; IODINE RADIOISOTOPES; PARKINSON DISEASE; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 33645457291     PISSN: 15452913     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinic-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55:181-184.
2. Hughes AJ, Daniel SE, Ben Shlomo Y, Lees AJ. The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain. 2002;125:861-870.
3. Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology. 2001;57:1497-1499.
4. 123I) beta-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in parkinsonian syndrome. Arch Neurol. 2004;61:1224-1229.
5. 123I] beta-CIT SPECT in clinical practice? J Neurol Neurosurg Psychiatry. 2005;76:1211-1216.
6. 123I] beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease. Eur J Nucl Med Mol Imaging. 2005;32:689-695.
7. Jaber M, Jones S, Giros B, et al. The dopamine transporter: a crucial component regulating dopamine transmission. Mov Disord. 1997;12:629-633.
8. Uhl GR. Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism. Mov Disord. 2003;18:S71-S80.
9. Counihan TJ, Penny JB. Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains. J Neurol Neurosurg Psychiatry. 1998;65:164-169.
10. Uhl GR. Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons. Ann Neurol. 1994;35:494-498.
11. Bezard E, Dovero S, Prunier C, et al. Relationship between the appearance of symptoms and the levels of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J Neurosci. 2001;21:6853-6861.
12. 123I]beta-CIT striatal uptake correlates with symptom severity in Parkinson's disease. Ann Neurol. 1995;38:589-598.
13. Benamer HT, Oertel WH, Patterson J, et al. Prospective study of presynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: part 1. Baseline and 3-month observations. Mov Disord. 2003;18:977-984.
14. 123I]-FP-CIT study group. Mov Disord. 2000;15:503-510.
15. A multicenter assessment of dopamine transporter imaging with DOPASCAN/SPECT in parkinsonism. Parkinson Study Group. Neurology. 2000;55:1540-1547.
16. 123I]beta-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. Mov Disord. 2000;15:1158-1167.
17. 123I]beta-CIT in Parkinson's disease and progressive supranuclear palsy, evaluated with single-photon emission tomography. Eur J Nucl Med. 1998;2S:1270-1276.
18. 123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy. Mov Disord. 2001;16:1023-1032.
19. Brooks DJ. Diagnosis and management of atypical parkinsonian syndromes. J Neurol Neurosurg Psychiatry. 2002;72(Suppl 1):1I0-I16.