Subcellular localization of Apaf-1 in apoptotic rat pituitary cells

American Journal of Physiology - Cell Physiology

Volumn 290, Issue 3, 2006, Pages

  Potokar, Maja ^a,b   Kreft, Marko ^a,b   Chowdhury, Helena H ^a,b   Vardjan, Nina ^b   Zorec, Robert ^a,b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b Celica Biomedical Sciences Center   (Slovenia)

Author keywords

Apoptosis; Apoptosome complex; Caspase 9; Cytochrome c

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CYTOCHROME C; ROTENONE; APAF1 PROTEIN, RAT; PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; HYPOPHYSIS CELL; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; HYPOPHYSIS; METABOLISM; PROTEIN TRANSPORT; WISTAR RAT;

ANIMALIA;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CELLS, CULTURED; CYTOCHROMES C; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MITOCHONDRIA; PITUITARY GLAND; PROTEIN TRANSPORT; PROTEINS; RATS; RATS, WISTAR; ROTENONE;

EID: 33645451081     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00331.2005     Document Type: Article

References (36)

1. Ashkenazi A and Dixit VM. Death receptors: signaling and modulation. Science 281: 1305-1308, 1998.
2. Bauer MF, Hofmann S, Neupert W, and Brunner M. Protein translocation into mitochondria: the role of TIM complexes. Trends Cell Biol 10: 25-31, 2000.
3. Ben-Tabou S, Keller E, and Nussinovitch I. Mechanosensitivity of voltage-gated calcium currents in rat anterior pituitary cells. J Physiol 476: 29-39, 1994.
4. Cain K, Brown DG, Langlais C, and Cohen GM. Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. J Biol Chem 274: 22686-22692, 1999.
5. Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, and Gruss P. Apaf-1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94: 727-737, 1998.
6. Chowdhury VS and Yoshimura Y. Cell proliferation and apoptosis in the anterior pituitary of chicken during inhibition and resumption of laying. Gen Comp Endocrinol 125: 132-141, 2002.
7. Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, and Dixit VM. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem 271: 16720-16724, 1996.
8. L. J Cell Biol 149: 623-634, 2000.
9. L interacts with Apaf-1 and inhibits Apaf-1 dependent caspase-9 activation. Proc Natl Acad Sci USA 95: 4386-4391, 1998.
10. Isenberg JS and Klaunig JE. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol Sci 53: 340-351, 2000.
11. Jiang X and Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J Biol Chem 275: 31199-31203, 2000.
12. Kerr JFR, Wyllie H, and Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
13. Kreft M, Milisav I, Potokar M, and Zorec R. Automated high throughput colocalization analysis of multichannel confocal images. Comput Methods Programs Biomed 74: 63-67, 2004.
14. Li H, Zhu H, Xu C, and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501, 1998.
15. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997.
16. Lindahl PE and Oberg KE. The effect of rotenone on respiration and its point of attack. Exp Cell Res 23: 228-237, 1961.
17. Liu X, Kim CN, Yang J, Jemmerson R, and Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157, 1996.
18. Luo X, Budihardjo I, Zou H, Slaughter C, and Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490, 1998.
19. Mayer A, Neupert W, and Lill R. Translocation of apocytochrome c across the outer membrane of mitochondria. J Biol Chem 270: 12390-12397, 1995.
20. Pei W, Liou AK, and Chen J. Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells. FASEB J 17: 520-522, 2003.
21. Potokar M, Milisav I, Kreft M, Stenovec M, and Zorec R. Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria. FEBS Lett 544: 153-159, 2003.
22. Rodriguez J and Lazebnik Y. Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev 13: 3179-3184, 1999.
23. Saleh A, Srinivasula SM, Acharya S, Fishel R, and Alnemri ES. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem 274: 17941-17945, 1999.
24. Salvesen GS and Dixit VM. Caspases: intracellular signaling by proteolysis. Cell 91: 443-446, 1997.
25. Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, and Alnemri ES. The Ced-3/interleukin 1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32. J Biol Chem 271: 27099-27106, 1996.
26. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, and Alnemri ES. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1: 949-957, 1998.
27. Torres AI, Pasolli HA, Maldonado CA, and Aoki A. Changes in thyrotroph and somatotroph cell populations induced by stimulation and inhibition of their secretory activity. Histochem J 27: 370-379, 1995.
28. Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, and Cain K. Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex. J Biol Chem 279: 19665-19682, 2004.
29. 2+ signaling in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neurosci Lett 376: 127-132, 2005.
30. Watabe M and Nakaki T. Rotenone induces apoptosis via activation of Bad in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther 311: 948-953, 2004.
31. Wei MC, Zong WX, Cheng EHY, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, and Korsmeyer SJ. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730, 2001.
32. Yu R and Melmed S. Oncogene activation in pituitary tumors. Brain Pathol 11: 328-341, 2001.
33. Yuan H, Mutomba M, Prinz I, and Gottlieb RA. Differential processing of cytosolic and mitochondrial caspases. Mitochondrion 1: 61-69, 2001.
34. Zorec R. Calcium signaling and secretion in pituitary cells. Trends Endocrinol Metab 7: 384-388, 1996.
35. Zou H, Henzel WJ, Liu X, Lutschg A, and Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413, 1997.
36. Zou H, Li Y, Liu X, and Wang X. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274: 11549-11556, 1999.