In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats

Synapse

Volumn 59, Issue 6, 2006, Pages 342-349

  Awtry, Tammy L ^a   Frank, Julie G ^a   Werling, Linda L ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Dihydro erythrodine; nAChR; Nicotine; PKA; Prefrontal cortex; SERT

Indexed keywords

ACETYLCHOLINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIHYDRO BETA ERYTHROIDINE; MECAMYLAMINE; NICOTINE; NICOTINIC RECEPTOR; SEROTONIN TRANSPORTER;

ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR; CELL MEMBRANE; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; ENZYME ACTIVITY; MOOD; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SEROTONINERGIC TRANSMISSION; SYNAPTOSOME;

ANIMALS; ATROPINE; CARBACHOL; CHOLINERGIC AGONISTS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIHYDRO-BETA-ERYTHROIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MECAMYLAMINE; MUSCARINIC ANTAGONISTS; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PREFRONTAL CORTEX; PROTEIN KINASE INHIBITORS; RATS; RECEPTORS, NICOTINIC; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SYNAPTOSOMES; THIONUCLEOTIDES; TIME FACTORS; TRITIUM;

EID: 33645422937     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20251     Document Type: Article

References (39)

1. 3H] methylcarbamylcholine in rat brain. Eur J Pharmacol 253:261-267.
2. 3H]ABT-418: a novel cholinergic channel ligand. J Pharmacol Exp Ther 273:1434-1441.
3. Awtry TL, Werling L. 2003. Acute and chronic effects of nicotine on serotonin uptake in prefrontal cortex and hippocampus of rats. Synapse 50:206-211.
4. Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, Blakely RD. 2000. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neurosci 20:7571-7578.
5. 3H](-)nicotine binding sites in fetal human brain. Brain Res 475:1-7.
6. Carson S, Godwin S, Massoulie J, Kato G. 1977. Solubilisation of atropine-binding material from brain. Nature 266:176-178.
7. Cassel JC, Jeltsch H. 1995. Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience 69:1-41.
8. Chavez-Nariega LE, Crona JH, Washburn MS, Urrutia A, Elliot KJ, Johnson EC. 1997. Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors α2β2, α2β4, α3β2, α3β4, α4β2, α4β4 and α7 expressed in Xenopus oocytes. J Pharmacol Exp Ther 280:346-356.
9. 4 receptor stimulation facilitates acetylcholine release in rat frontal cortex. NeuroReport 5:1230-1232.
10. Cool DR, Leibach FH, Bhalla VK, Mahesh VB, Ganapathy V. 1991. Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). J Biol Chem 266:15750-15757.
11. Dajas-Bailador FA, Soliakov L, Wonnacott S. 2002. Nicotine activates the extracellular signal-related kinase 1/2 via the α7 nicotinic acetylcholine receptor and protein kinase A, in SH-SY5Y cells and hippocampal neurons. J Neurochem 80:520-530.
12. Flores CM, Rogers SW, Pabreza LA, Wolfe BB, Kellar KJ. 1992. A subytpe of nicotine cholinergic receptor in rat brain is composed of α4β2 subunits and is upregulated by chronic nicotine treatment. Mol Pharmacol 41:31-37.
13. 14C]nicotine. Drug Metab Dispos 29:645-651.
14. Graeff FG, Guimaraes FS, De Andrade TGCS, Deakin JFW 1996. Role of 5-HT in stress, anxiety and depression. Pharmacol Biochem Behav 54:129-141.
15. Harrison AA, Markou A. 2001. Serotonergic manipulations both potentiate and reduce brain stimulation reward in rats: involvement of serotonin-1A receptors. J Pharmacol Exp Ther 297:316-325.
16. Jayanthi LD, Ramamoorthy S, Mahesh VB, Leibach FH, Ganapathy V. 1994. Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. J Biol Chem 269:14424-14429.
17. Johnston AL, File SE. 1986. 5-HT and anxiety, promises and pitfalls. Pharmacol Biochem Behav 24:1467-1470.
18. Marubio LM, del Mar Arroyo-Jimenez M, Cordero-Erausquin M, Lena C, Le Novere N, de Kerchove d'Exaerde A, Huchet M, Damaj MI, Changeux JP. 1999. Reduced antinociception in mice lacking neuronal nicotinic subunits. Nature 398:805-810.
19. Maura G, Andrioli G, Cavazzani P, Raiteri M. 1992. 5-Hydroxytryptamine3 receptors sited on cholinergic axon terminals of human cerebral cortex mediate inhibition of acetylcholine release. J Neurochem 58:2334-2337.
20. Meneses A. 1999. 5-HT system and cognition. Neurosci Biobehav Rev 23:1111-1125.
21. Muneoka K, Ogawa T, Kamei K, Muraoka S, Tomiyoshi R, Mimura Y, Kato H, Suzuki T, Takigawa M. 1997. Prenatal nicotine exposure affects the development of the central Serotonergic system as well as the dopaminergic system in rat offspring: involvement of route of drug administrations. Dev Brain Res 102:117-126.
22. Muneoka K, Ogawa T, Kamei K, Mimura Y, Kato H, Takigawa M. 2001. Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain. Eur J Pharmacol 411:279-282.
23. Murphy JM, McBride WJ, Lumeng L, Li TK. 1987. Contents of monoamines in forebrain regions of alcohol-prefering (P) and nonprefering (NP) lines of rats. Pharmacol Biochem Behav 26:389-392.
24. Peng X, Gerzanich V, Anand R, Whiting PJ, Lindstrom J. 1994. Nicotine induced increases in neuronal nicotinic receptors result from a decrease in rate of receptor turnover. Mol Pharmacol 46:523-530.
25. Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, Fuxe K, Changeux JP. 1995. Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature 374:65-67.
26. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD. 2005. Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proc Natl Acad Sci USA 102:11545-11550.
27. Qian Y, Galli A, Ramamoorthy S, Risso S, DeFelice LJ, Blakely RD. 1997. Protein kinases C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J Neurosci 17:45-57.
28. Ramamoorthy S, Blakely RD. 1999. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 285:763-766.
29. Ramamoorthy S, Giovanetti E, Qian Y, Blakely RD. 1998. Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. J Biol Chem 273:2458-2466.
30. Riekkinen M, Sirvio J, Riekkinen P, Jr. 1993. Pharmacological consequences of nicotinergic plus serotonergic manipulations. Brain Res 622:139-146.
31. Rothermel JD, Parker Botelho LH. 1988. A mechanistic and kinetic analysis of the interactions of the diastereomers of adenosine 3′,5′- (cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J 251:757-762.
32. Scholubbers HG, van Knippenberg PH, Baraniak J, Stec WJ, Morr M, Jastorff B. 1984. Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues: biological activities and structure-activity correlations. Eur J Biochem 138:101-109.
33. Seth P, Cheeta S, Tucci S, File S. 2002. Nicotinic-serotonergic inter-actions in brain and behavior. Pharmacol Biochem Behav 71:795-805.
34. Sirvio J, Riekkinen P, Jr., Jakala P, Riekkinen PJ. 1994. Experimental studies on the role of serotonin in cognition. Prog Neurobiol 43:363-379.
35. Summers KL, Giacobini E. 1995. Effects of local and repeated systemic administration of (-) nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine and serotonin in rat cortex in vivo. Neurochem Res 20:753-759.
36. Verkes RJ, Gijsman HJ, Pieters MSM, Schoemaker RC, de Visser S, Kuijpers M, Pennings EJM, de Bruink D, Van de Wijngaart G, Van Gerve JMA, Cohen AF. 2001. Cognitive performance and serotonergic function in users of ecstasy. Psychopharmacology 153:196-202.
37. Whiting PJ, Schoepfer R, Lindstrom J, Priestly T. 1991. Structural and pharmacological characterization of major brain nicotinic acetylcholine receptor subtypes stably expressed in mouse fibroblasts. Mol Pharmacol 40:463-472.
38. Xiao Y, Meyer EL, Thompson JM, Surin A, Wroblewski J, Kellar KJ. 1998. Rat α3β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and functions. Mol Pharmacol 54:322-333.
39. - -dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. J Pharmacol Exp Ther 92:21-55.