Tissue uptake of DDT is independent of chylomicron metabolism

Archives of Toxicology

Volumn 80, Issue 4, 2006, Pages 196-200

  Trevaskis, Natalie L ^a   Tso, Patrick ^b   Rider, Therese ^b   Charman, William N ^a   Porter, Christopher J H ^a   Jandacek, Ronald ^b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Chylomicron; Clearance; DDT; Distribution; Lipoprotein

Indexed keywords

CARBON 14; CHLORPHENOTANE; CHOLESTEROL; CHOLESTEROL ESTER; CHYLOMICRON; OLIVE OIL; TRITIUM;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY FAT; BRAIN; CANNULATION; CAROTID ARTERY; CONTROLLED STUDY; DRUG UPTAKE; FEEDING; HEART; INTESTINE ABSORPTION; JUGULAR VEIN; LIPID TRANSPORT; LIPOPROTEIN METABOLISM; LIVER; MALE; MESENTERY LYMPH NODE; NONHUMAN; PRIORITY JOURNAL; RAT; RETROPERITONEUM; SPLEEN; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

ANIMALS; AREA UNDER CURVE; CHOLESTEROL; CHOLESTEROL ESTERS; CHYLOMICRONS; DDT; INFUSIONS, INTRAVENOUS; INSECTICIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 33645413417     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0028-2     Document Type: Article

References (11)

1. Gold B, Brunk G (1982) Metabolism of 1,1,1-trichloro-2,2-bis(p- chlorophenyl)-ethane and 1,1-dichloro-2,2-bis(p-chlorophenyl) ethane in the mouse. Chem Biol Interact 41:327-339
2. Gold B, Brunk G (1983) Metabolism of 1,1,1-trichloro-2,2-bis(p- chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane, and 1-chloro-2,2-bis(p-chlorophenyl)ethene in the hamster. Cancer Res 43:2644-2647
3. Hunter DJ, Hankinson SE, Laden F, Colditz GA, Manson JE, Willett WC, Speizer FE, Wolff MS (1997) Plasma organochlorine levels and the risk of breast cancer. N Engl J Med 337:1253-1258
4. Jandacek RJ, Zheng S, Yang Q, Tso P (2005) Rapid clearance of hexachlorobenzene from chylomicrons. Lipids 39:993-995
5. Palin KJ, Wilson CG, Davis SS, Phillips AJ (1982) The effect of oils on the lymphatic absorption of DDT. J Pharm Pharmacol 34:707-710
6. Pocock DE, Vost A (1974) DDT absorption and chylomicron transport in rat. Lipids 9:374-381
7. Porter CJ, Charman WN (2001) Intestinal lymphatic drug transport: an update. Adv Drug Deliv Rev 50:61-80
8. Sieber SM, Cohn VH, Wynn WT (1974) The entry of foreign compounds into the thoracic duct lymph of the rat. Xenobiotica 4:265-284
9. Smith A (1991) Chlorinated hydrocarbon insecticides. In: Handbook of pesticides toxicology. Academic Press Inc., San Diego, New York
10. Turusov V, Rakitsky V, Tomatis L (2002) Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence, and risks. Environ Health Perspect 110:125-128
11. Vost A, Maclean N (1984) Hydrocarbon transport in chylomicrons and high-density lipoproteins in rat. Lipids 19:423-435