Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors

Journal of Medicinal Chemistry

Volumn 49, Issue 6, 2006, Pages 2063-2076

  Zhu, Guangyu ^a   Yang, Fanglong ^a   Balachandran, Raghavan ^a   Höök, Peter ^b   Vallee, Richard B ^b   Curran, Dennis P ^a   Day, Billy W ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 (3 AMINOPROPOXY) 3 BROMOPHENYL] N [2 (4 CHLOROPHENYL)ETHYL] 2 HYDROXYIMINOPROPANAMIDE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; DYNEIN ADENOSINE TRIPHOSPHATASE; DYNEIN ADENOSINE TRIPHOSPHATASE INHIBITOR; ENZYME INHIBITOR; NATURAL PRODUCT; PUREALIDIN A; PUREALIN; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AXONEME; CANCER CELL CULTURE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HEAVY CHAIN; HUMAN; HUMAN CELL; MICROTUBULE; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; PSAMMAPLYSILLA PUREA; REACTION ANALYSIS; SPONGE (PORIFERA); STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTINEOPLASTIC AGENTS; BROMOBENZENES; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DYNEIN ATPASE; HUMANS; KINETICS; MICE; PORIFERA; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33645410730     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051030l     Document Type: Article

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