Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy

Muscle and Nerve

Volumn 33, Issue 4, 2006, Pages 494-499

  Berghoff, Martin ^a,b   Kilo, Sonja ^b   Hilz, Max J ^c   Freeman, Roy ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Autonomic function; Axon reflex; C fiber; Diabetes; Dysautonomia; Laser Doppler flowmetry; Silastic imprint method

Indexed keywords

ADULT; ARTICLE; AXON REFLEX; CLINICAL ARTICLE; CONTROLLED STUDY; DEVICE; DIABETIC NEUROPATHY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LASER FLOWMETER; MALE; MOTOR ACTIVITY; NERVE FIBER C; NERVE FUNCTION; NOCICEPTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; SENSORY NERVE; SWEATING; SYMPATHETIC TONE;

ACETYLCHOLINE; ADULT; AXONS; DATA INTERPRETATION, STATISTICAL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; FOREARM; HUMANS; IONTOPHORESIS; MALE; MIDDLE AGED; NERVE FIBERS, UNMYELINATED; NOCICEPTORS; REFLEX; REGIONAL BLOOD FLOW; SKIN; SWEATING; SYMPATHETIC NERVOUS SYSTEM; VASODILATION; VASODILATOR AGENTS;

EID: 33645359217     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.20497     Document Type: Article

References (22)

1. Ahmed ME, Le Quesne PM. Quantitative sweat test in diabetics with neuropathic foot lesions. J Neurol Neurosurg Psychiatry 1986;49:1059-1062.
2. Benarroch EE, Low PA. The acetylcholine-induced flare response in evaluation of small fiber dysfunction. Ann Neurol 1991;29:590-595.
3. Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R. Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol 2002;92:780-788.
4. Bickel A, Kramer HH, Hilz MJ, Birklein F, Neundorfer B, Schmelz M. Assessment of the neurogenic flare reaction in small-fiber neuropathies. Neurology 2002;59:917-919.
5. Bradley JL, Thomas PK, King RH, Muddle JR, Ward JD, Tesfaye S, et al. Myelinated nerve fibre regeneration in diabetic sensory polyneuropathy: correlation with type of diabetes. Acta Neuropathol (Berl) 1995;90:403-410.
6. Britland ST, Young RJ, Sharma AK, Clarke BF. Association of painful and painless diabetic polyneuropathy with different patterns of nerve fiber degeneration and regeneration. Diabetes 1990;39:898-908.
7. Caselli A, Rich J, Hanane T, Uccioli L, Veves A. Role of C-nociceptive fibers in the nerve axon reflex-related vasodilation in diabetes. Neurology 2003;60:297-300.
8. Fealey RD, Low PA, Thomas JE. Thermoregulatory sweating abnormalities in diabetes mellitus. Mayo Clin Proc 1989;64:617-628.
9. Hoeldtke RD, Bryner KD, Horvath GG, Phares RW, Broy LF, Hobbs GR. Redistribution of sudomotor responses is an early sign of sympathetic dysfunction in type 1 diabetes. Diabetes 2001;50:436-443.
10. Kennedy JM, Zochodne DW. The regenerative deficit of peripheral nerves in experimental diabetes: its extent, timing and possible mechanisms. Brain 2000;123:2118-2129.
11. Kennedy WR, Navarro X, Kamei H. Reinnervation of sweat glands in the mouse: axonal regeneration versus collateral sprouting. Muscle Nerve 1988;11:603-609.
12. Kennedy WR, Sakuta M, Sutherland D, Goetz FC. Quantitation of the sweating deficiency in diabetes mellitus. Ann Neurol 1984;15:482-488.
13. Kennedy WR, Sakuta M, Sutherland D, Goetz FC. The sweating deficiency in diabetes mellitus: Methods of quantitative and clinical correlation. Neurology 1984;34:758-763.
14. Kilo S, Berghoff M, Hilz M, Freeman R. Neural and endothelial control of the microcirculation in diabetic peripheral neuropathy. Neurology 2000;54:1246-1252.
15. Lang E, Spitzer A, Claus D, Neundorfer B, Handwerker HO. Stimulation of sudomotor axon reflex mechanism by carbachol in healthy subjects and patients suffering from diabetic polyneuropathy. Acta Neurol Scand 1995;91:251-254.
16. Longo FM, Powell HC, Lebeau J, Gerrero MR, Heckman H, Myers RR. Delayed nerve regeneration in streptozotocin diabetic rats. Muscle Nerve 1986;9:385-393.
17. Low PA, Caskey PE, Tuck RR, Fealey RD, Dyck PJ. Quantitative sudomotor axon reflex test in normal and neuropathic subjects. Ann Neurol 1983;14:573-580.
18. Parkhouse N, Le Quesne PM. Impaired neurogenic vascular response in patients with diabetes and neuropathic foot lesions. N Engl J Med 1988;318:1306-1309.
19. Pierson CR, Zhang W, Murakawa Y, Sima AA. Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy. J Neuropathol Exp Neurol 2003;62:260-271.
20. Polydefkis M, Hauer P, Sheth S, Sirdofsky M, Griffin JW, McArthur JC. The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain 2004;127:1606-1615.
21. Stewart JD, Nguyen DM, Abrahamowicz M. Quantitative sweat testing using acetylcholine for direct and axon reflex mediated stimulation with silicone mold recording; controls versus neuropathic diabetics. Muscle Nerve 1994;17:1370-1377.
22. Theriault M, Dort J, Sutherland G, Zochodne DW. A prospective quantitative study of sensory deficits after whole sural nerve biopsies in diabetic and nondiabetic patients. Surgical approach and the role of collateral sprouting. Neurology 1998;50:480-484.