Preliminary evaluation of polymer-based drug composite microparticle production by coacervate desolvation with supercritical carbon dioxide

Journal of Pharmaceutical Sciences

Volumn 95, Issue 3, 2006, Pages 581-588

  Yasuji, Takehiko ^a,b   Haslam, John ^a   Kajiyama, Atsushi ^b   McIntosh, Michelle P ^a   Rajewski, Roger A ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Dissolution rate; Microparticles; Polymers; Solid dispersion; Supercritical fluids

Indexed keywords

ALCOHOL; CARBON DIOXIDE; HEXANE; PHENYTOIN; POLYMER; POVIDONE; SOLVENT;

AEROSOL; ARTICLE; CHEMICAL INTERACTION; COACERVATION; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; PARTICLE SIZE; PRECIPITATION; SOLID; SOLVATION; SUPERCRITICAL FLUID; ULTRASOUND; ULTRAVIOLET RADIATION; VISCOSITY; X RAY DIFFRACTION;

EID: 33645332606     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20565     Document Type: Review

References (15)

1. Perrut M. 2000. Supercritical fluid applications: Industrial developments and economic issues. Ind Eng Chem Res 39:4531-4535.
2. Phillips EM, Stella VJ. 1993. Rapid expansion from supercritical solutions application to pharmaceutical processes. Int J Pharm 94:1-10.
3. Subramaniam B, Saim S, Rajewski RA, Snavely K. 1997. Pharmaceutical processing with supercritical carbon dioxide. J Pharm Sci 86:885-890.
4. Jung J, Perrut M. 2001. Particle design using supercritical fluids: Literature and patent survey. J Supercritical Fluids 20:179-219.
5. York P, Kompella UB, Shekunov BY, editors. 2004. Supercritical fluid technology for drug product development. Drugs and the pharmaceutical sciences, Vol. 138. New York: Marcel Dekker, Inc. 631p.
6. Gander B, Blanco-Prieto MJ, Thomasin C, Wandrey C, Hunkeler D. 2002. In: Swarbrick J, Boylan JC, editors. Coacervation/phase separation in Encycl. Pharm. Technol., 2nd edn. New York: Marcel Dekker, Inc. pp 481-496.
7. Subramaniam B, Saim S, Rajewski RA, Stella VJ. 1998. Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvent. U.S. Patent 5,833,891, issued Nov. 10.
8. Snavely WK, Subaramaniam B, Rajewski RA, Defelipps MR. 2002. Micronization of insulin from halogenated alcohol solution using supercritical carbon dioxide as an antisolvent. J Pharm Sci 91:2026-2039.
9. Subramaniam B, Rajewski RA, Snavely K. 1997. Pharmaceutical processing with supercritical carbon dioxide. J Pharm Sci 8:885-890.
10. Bleich J, Müller BW. 1996. Production of drug loaded microparticles by the use of supercritical gases with the Aerosol Solvent Extraction System (ASES) process. J Microencapsulation 13:131-139.
11. Jachowicz R. 1987. Dissolution rates of partially water-soluble drugs from solid dispersion systems. II. Phenytoin. Int J Pharm 35:7-12.
12. Yakou S, Umehara K, Sonobe T, Nagai T, Sugihara M, Fukuyama Y. 1984. Particle size dependency of dissolution rate and human bioavailability of phenytoin in powders and phenytoin-polyethylene glycol solid dispersion. Chem Pharm Bull 32:4130-4136.
13. York P, Wilkins SA, Storey RA, Walker SE, Harland RS. 2001. Coformulation methods and their products. Patent application WO 01/15664 A2, 8 March.
14. Ghaderi R, Artursson P, Carlfors J. 2000. A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids. Eur J Pharm Sci 10:1-9.
15. Juppo AM, Boissier C, Khoo C. 2003. Evaluation of solid dispersion particles prepared with SEDS. Int J Pharm 250:385-401.