Synthesis of potent water soluble forskolin analogues

Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

Volumn 45, Issue 1, 2006, Pages 232-246

  Lal, Bansi ^a   Gangopadhyay, Ashok Kumar ^a   Gidwani, Ramesh M ^a   Rajagopalan, Ramanujam ^a,b   Ghate, Anil V ^a  

^a Quest Institute of Life Sciences   (India)

^b DR REDDY S RESEARCH FOUNDATION   (India)

Author keywords

halo acid; Acrylic acid; Aliphatic amine; Forskolin; Heterocyclic amine; Hydroxyacyl forskolin; Inotropic activity; Michael addition; Water soluble

Indexed keywords

EID: 33645331829     PISSN: 03764699     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Bansi Lal, Gangopadhyay A K, Aroskar V A, Dohadwalla A N & Rupp R H Eur Pat EP 293814; Chem, Abst,. 1989, 110, 213140x.
2. Barlos K, Papaioannou D & Theodoropoulos D, J Org Chem, 47, 1982, 1324.
3. Stammer C H & Webb RG, Tetrahedron Lett. 40, 1966, 4895.
4. Trit-Abu & Trit-Gly-Gly was prepared following the procedure in ref. 2.
5. Bansi Lal, Gangopadhyay A K, Gidwani R M, Fernandes M, Rajagopalan R, & Ghate A V, Bioorg Med Chem, 6, 1998, 2075.
6. Abdulla R F & Brinkmeyer R S, Tetrahedron. 35, 1979, 1675.
7. Corey E J & Venkateswarlu A, J Am Chem Soc 94, 1972, 6190.
8. Khandelwal Y, Rajeshwari K, Rajagopalan R, Swamy L, Dohadvvaila A N, de Souza N J & Rupp R H, J Med Chem, 31, 1988, 1872.
9. Tatee T, Narita A, Hosono M, Yanashita K, Enomoto K & Shiozawa A, Chem Pharm Bull, 44(12), 1996, 2274.