Crystal structure and physical properties of two polymorphs of ropivacaine HCl

Journal of Pharmaceutical Sciences

Volumn 95, Issue 3, 2006, Pages 680-688

  Bergström, Per Olov ^a,b   Fischer, Andreas ^b   Kloo, Lars ^b   Sebhatu, Tesfai ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

Crystal structure; Physical stability; Polymorphism; Solid state; Solubility; Solution calorimetry; Thermodynamics

Indexed keywords

ROPIVACAINE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; HYDROGEN BOND; THERMODYNAMICS;

EID: 33645328041     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20518     Document Type: Review

References (11)

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9. The length per molecule along the H-bonding direction, LPM, and the area per H-bond chain perpendicular to the H-bonding direction, APC, were calculated according to LPM = L/M and APC = A/C where L is the length of the unit cell axis parallell to the H-bond chain direction, M is the number of molecules in one H-bonded chain within the unit cell, A is the area of the unit cell perpendicular to the H-bond chain direction and C is the number of chains within the unit cell.
10. [SHELXS97]: G.M. Sheldrick: SHELXS97, a Program for Crystal Structure Determination, University of Göttingen, Germany, 1997.
11. [SHELXL97]: G.M. Sheldrick: SHELXS97, a Program for Crystal Structure Refinement, University of Göttingen, Germany, 1997.