Evaluation of the risk of motor neuron disease in horses fed a diet low in vitamin E and high in copper and iron

American Journal of Veterinary Research

Volumn 67, Issue 1, 2006, Pages 120-126

  Divers, Thomas J ^a   Cummings, John E ^a   de Lahunta, Alexander ^a   Hintz, Harold F ^b   Mohammed, Hussni O ^a  

^a Department of Obstetrics Gynecology   (United States)

^b Plant Breeding and Genetics Section in the School of Integrative Plant Science   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE; COPPER; IRON; RETINOL; SELENIUM;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE DISEASE; MALE; MOTOR NEURON DISEASE; NONHUMAN; RISK ASSESSMENT; RISK FACTOR; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VITAMIN SUPPLEMENTATION;

ANIMALS; COPPER; DIET; FERRITINS; HORSE DISEASES; HORSES; IRON; LIVER; MOTOR NEURON DISEASE; RISK ASSESSMENT; SELENIUM; VITAMIN A; VITAMIN E DEFICIENCY;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 33645327172     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.1.120     Document Type: Article

References (46)

1. Cummings JF, de Lahunta A, George C, et al. Equine motor neuron disease: a preliminary report. Cornell Vet 1990;80:357-379.
2. Divers TJ, Mohammed HO, Cummings JF, et al. Equine motor neuron disease: findings in 28 horses and proposal of a pathophysiologic mechanism for the disease. Equine Vet J 1994;26:409-415.
3. Hahn C, Mayhew IG. Does equine motor neuron disease exist inthe United Kingdom? Vet Rec 1993;132:133-134.
4. Proudman CJ, Knottenbelt DC, Edwards GB. Equine motor neuron disease. Vet Rec 1993;132:198-199.
5. Kuwamura M, Iwaki M, Yamate J, et al. The first case of equine motor neuron disease in Japan. J Vet Med Sci 1994;56:195-197.
6. Prendergast M, Bassett HF, Cummings JF. Equine motor neuron disease. Vet Rec 1994;135:416.
7. Landolt G, Feige K, Grest P. Equine motor neuron disease (EMND). A case report. Tierarztl Prax 1997;25:241-243.
8. Benders NA, Wijnberg ID, van der Kolk JH. Equine motor neuron disease: a review based on a case report. Tijdschr Diergeneeskd 2001;126:376-380.
9. Weber Polack E, King JM, Cummings JF, et al. Quantitative assessment of motor neuron loss in equine motor neuron disease (EMND). Equine Vet J 1998;30:256-259.
10. Divers TJ, Valentine BA, Jackson CA, et al. Simple and practical muscle biopsy test for equine motor neuron disease, in Proceedings. 42nd Annu Conv Am Assoc Equine Pract 1996;180-181.
11. Jackson CA, de Lahunta A, Cummings JF, et al. Spinal accessory nerve biopsy as an antemortem diagnostic test for equine motor neuron disease. Equine Vet J 1996;28:215-219.
12. Cummings JF, de Lahunta A, Summers BA, et al. Eosinophilic cytoplasmic inclusions in sporadic equine motor neuron disease: an electron microscopic study. Acta Neuropathol (Berl) 1993;85:291-297.
13. Valentine BA, de Lahunta A, George C, et al. Acquired equine motor neuron disease. Vet Pathol 1994;31:130-138.
14. Riis RC, Jackson C, Rebhun W, et al. Ocular manifestations of equine motor neuron disease. Equine Vet J 1999;31:99-110.
15. Cummings JF, de Lahunta A, Mohammed HO, et al. Endothelial lipopigment as an indicator of α-tocopherol deficiency in two equine neurodegenerative diseases. Acta Neuropathol (Berl) 1995; 90:266-272.
16. Mohammed HO, Cummings JF, Divers TJ, et al. Epidemiology of equine motor neuron disease. Vet Res 1994;25:275-278.
17. de la Rua-Domenech R, Mohammed HO, Atwill ER, et al. Epidemiologic evidence for clustering of equine motor neuron disease in the United States. Am J Vet Res 1995;56:1433-1439.
18. de la Rua-Domenech R, Mohammed HO, Cummings JF, et al. Incidence and risk factors of equine motor neuron disease: an ambidirectional study. Neuroepidemiology 1995;14:54-64.
19. de la Rua-Domenech R, Mohammed HO, Cummings JF, et al. Intrinsic, management, and nutritional factors associated with equine motor neuron disease. J Am Vet Med Assoc 1997;211:1261-1267.
20. de la Rua-Domenech R, Mohammed HO, Cummings JF, et al. Association between plasma vitamin E concentration and the risk of equine motor neuron disease. Vet J 1997;143:173-174.
21. Polack EW, King JM, Cummings JF, et al. Concentrations of trace minerals in the spinal cord of horses with equine motor neuron disease. Am J Vet Res 2000;61:609-611.
22. Divers TJ, de Lahunta A, Hintz HF, et al. Equine motor neuron disease. Equine Vet Educ 2001;13:63-67.
23. Smith JD, Jordan RM, Nelson ML. Tolerance of ponies to high levels of dietary copper. J Anim Sci 1975;41:1645-1649.
24. Lawrence LA, Ott EA, Asqueth RL, et al. Influence of dietary iron on growth, tissue mineral composition. Apparent phosphorus absorption and chemical and mechanical properties of bones of ponies, in Proceedings. 10th Equine Nutr Physiol Soc Symp 1987;563-572.
25. Kapper DR. Elements of nutrition: a primer for practitioners, in Proceedings. 38th Annu Conv Am Assoc Equine Pract 1992;669-679.
26. Blatt DH, Pryor WA, Mata JE, et al. Re-evaluation of the relative potency of synthetic and natural alpha-tocopherol: experimental and clinical observations. J Nutr Biochem 2004;15:380-395.
27. Vatassery GT, Adityanjee, Quach HT, et al. α- and γ-Tocopherols in cerebrospinal fluid and serum from older, male, human subjects. J Am Coll Nutr 2004;23:233-238.
28. + with dioxygen; comparison with the Fenton chemistry. Acta Biochim Pol 2000;47:951-962.
29. Rao AV, Balachandran B. Role of oxidative stress and antioxidants in neurodegenerative diseases. Nutr Neurosci 2002;5:291-309.
30. Cookson MR, Shaw PJ. Oxidative stress and motor neuron disease. Brain Pathol 1999;9:65-86.
31. Mohammed HO, Divers TJ, de Lahunta A. Vitamin E deficiency and risk of equine motor neuron disease. Can Vet J 2006;in press.
32. Pearson EG, Andreasen CB. Effect of oral administration of excessive iron in adult ponies. J Am Vet Med Assoc 2001;218:400-404.
33. Lewis LD. Equine clinical nutrition: feedings and care. Baltimore:The Williams & Wilkins Co, 1995;39-41, 64-69.
34. Maenpaa PH, Koskinen T, Koskinen E. Serum profiles of vitamins A, E and D in mares and foals during different seasons. J Anim Sci 1988;66:1418-1423.
35. Blakley BR, Bell RJ. The vitamin A and vitamin E status of horses raised in Alberta and Saskatchewan. Can Vet J 1994;35:297-300.
36. National Research Council. Nutrient requirements of the horse. Washington, DC: National Research Council, 1989;16-17.
37. Feki M, Souissi M, Mebazaa A. Vitamin E: biochemical, clinical and epidemiological aspects. Ann Med Interne (Paris) 2001; 152:384-391.
38. Brigelius-Flohe R, Traber MG. Vitamin E: function and metabolism. FASEB J 1999;13:1145-1155.
39. Ronéus BO, Hakkarainen RVJ, Lindholm CA, et al. Vitamin E requirements of adult Standardbred horses evaluated by tissue depletion and repletion. Equine Vet J 1986;18:50-58.
40. Butterfield DA, Castegna A, Drake J, et al. Vitamin E and neurodegenerative disorders associated with oxidative stress. Nutr Neurosci 2002;5:229-239.
41. Esposito E, Rotilio D, Di Matteo V, et al. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 2002; 23:719-735.
42. Gurney ME, Cutting FB, Zhai P, et al. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 1996;39:147-157.
43. Green SL, Bouley DM, Pinter MJ, et al. Canine motor neuron disease: clinicopathologic features and selected indicators of oxidative stress. J Vet Intern Med 2001;15:112-119.
44. Davidson MG, Geoly FJ, Gilger BC, et al. Retinal degeneration associated with vitamin E deficiency in hunting dogs. J Am Vet Med Assoc 1998;213:645-651.
45. Blythe LL, Craig AM, Lassen ED, et al. Serially determined plasma α-tocopherol concentrations and results of the oral vitamin E absorption test in clinically normal horses and in horses with degenerative myeloencephalopathy. Am J Vet Res 1991; 52:908-911.
46. Craig AM, Blythe LL. Antioxidants: diseases associated with deficiencies and therapeutic usages, in Proceedings. 38th Annu Conv Am Assoc Equine Pract 1992;579-580.