Randomized placebo-controlled trial comparing montelukast and cetirizine for treating perennial allergic rhinitis in children aged 2-6 yr

Pediatric Allergy and Immunology

Volumn 17, Issue 1, 2006, Pages 49-54

  Chen, Shuei Tu ^a   Lu, Ko Hsiu ^b   Sun, Hai Lun ^a,b   Chang, Wen Tung ^a   Lue, Ko Huang ^a,b   Chou, Ming Chih ^b  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Allergic rhinitis; Cetirizine; H1 receptor antagonist; Leukotriene receptor antagonist; Montelukast

Indexed keywords

CETIRIZINE; EOSINOPHIL CATIONIC PROTEIN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; PLACEBO;

ALLERGIC RHINITIS; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EOSINOPHIL COUNT; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LACRIMATION; MAJOR CLINICAL STUDY; MALE; NASAL PRURITUS; NOSE AIRWAY RESISTANCE; NOSE SMEAR; PEDIATRIC RHINOCONJUNCTIVITIS QUALITY OF LIFE QUESTIONNAIRE; PERENNIAL RHINITIS; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEDATION; SLEEP; SOMNOLENCE; THROAT; TOTAL SYMPTOM SCORE;

ACETATES; ANTI-ALLERGIC AGENTS; CETIRIZINE; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; QUINOLINES; RHINITIS, ALLERGIC, PERENNIAL;

EID: 33645325674     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2005.00351.x     Document Type: Article

References (29)

1. B ousquet J. Allergic Rhinitis and its Impact on Asthma (ARIA). Clin Exp All Rev 2003 3 43 45.
2. B ousquet J V ignola AM C ampbell AM M ichel FB. Pathophysiology of allergic rhinitis. Int Arch Allergy Immunol 1996 110 207 18.
3. S torms WW. Rethinking our approach to allergic rhinitis management. Ann Allergy Asthma Immunol 2002 88 Suppl. 1 30 35.
4. van C auwenberge P B achert C P assalacqua G et al. Consensus statement on the treatment of allergic rhinitis. European academy of allergology and clinical immunology. Allergy 2000 55 116 34.
5. W ang D C lement P S mitz J D erde MP. Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. Acta Otolaryngol 1994 114 552 5.
6. K nani J C ampbell A E nander I et al. Indirect evidence of nasal inflammation assessed by titration of inflammatory mediators and enumeration of cells in nasal secretions of patients with chronic rhinitis. J Allergy Clin Immunol 1992 90 880 9.
7. 4 on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans. Clin Allergy 1986 16 289 97.
8. 4 in allergic rhinitis. Ann Allergy 1988 60 537 40.
9. H owarth PH S alagean M D okic D. Allergic rhinitis: not purely a histamine-related disease. Allergy 2000 55 Suppl. 64 7 16.
10. M eltzer EO. Role for cysteinyl leukotriene receptor antagonist therapy in asthma and their potential role in allergic rhinitis based on the concept of 'one linked airway disease'. Ann Allergy Asthma Immunol 2000 84 176 87.
11. P hilip G M almstrom K H ampel FC et al. Montelukast for treating seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial performed in the spring. Clin Exp Allergy 2002 32 1020 8.
12. V an A delsberg J P hilip G C raig F et al. Randomized controlled trial evaluating the clinical benefit of montelukast for treating spring seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2003 90 214 22.
13. N ayak AS P hilip G L u S et al. Efficacy and tolerability of montelukast alone or in combination with loratadine in seasonal allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled trial performed in the fall. Ann Allergy Asthma Immunol 2002 88 592 600.
14. V an C auwenberge P D e B elder T V ermeiren J K aplan A. Global Resources in Allergy (GLORIA): allergic rhinitis and allergic conjunctivitis. Clin Exp All Rev 2003 3 46 50.
15. P ullerists T P raks L S koogh BE et al. Randomized placebo-controlled study comparing a leukotriene receptor antagonist and a nasal glucocorticoid in seasonal allergic rhinitis. Am J Respir Crit Care Med 1999 159 1814 8.
16. M almstrom K M eltzer EO P renner B et al. Effects of montelukast (a leukotriene receptor antagonist), loratadine, montelukast + loratadine and placebo in seasonal allergic rhinitis and conjunctivitis (Abstract). J Allergy Clin Immunol 1998 101 S97.
17. O wicz MA Z uccotti F R izack MA et al. Montelukast (Singulair) for allergic rhinitis. Med Lett Drugs Ther 2003 45 21 22
18. J uniper EF H owland WC R oberts NB et al. Measuring quality of life in children with rhinoconjunctivitis. J Allergy Clin Immunol 1998 101 163 70.
19. Micro Medical Limited. MicroRint Operating Manual. Park Gillingham Kent ME8 0NJ England: Revision 1.5 May 1997
20. L ai D-S L ue K-H H sieh J-C et al. The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis. Ann Allergy Asthma Immunol 2002 89 589 98.
21. H sieh J-C L ue K-H L ai D-S et al. A comparison of Cetirizine and Montelukast for Treating Childhood Perennial Allergic Rhinitis. Pediatr Asthma Allergy Immunol 2004 17 59 69.
22. B ehrendt H R ing J. Histamine, antihistamines and atopic eczema. Clin Exp Allergy 1990 20 Suppl. 25 30.
23. B ousquet J van C auwenberge P K haltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001 108 Suppl. S147 336.
24. P hilips DE J ones AS H offman J G illes J. Distribution of eosinophils in nose in patients with perennial rhinitis. Clin Otolaryngol 1992 17 478 81.
25. A min K R inne J H aahtela T et al. Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years' duration. J Allergy Clin Immunol 2001 107 249 57.
26. P ullerits T P raks L R istioja V L tvall J. Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 2002 109 949 55.
27. K lementsson H A ndersson M P ipkorn U. Allergen-induced increase in nonspecific nasal reactivity is blocked by antihistamines without a clear-cut relationship to eosinophil influx. J Allergy Clin Immunol 1990 86 466 72.
28. 1 antagonist. Allergy Proc 1991 12 187 91.
29. R obert A. Nathan. Pharmacotherapy for allergic rhinitis: a critical review of leukotriene receptor antagonists compared with other treatments. Ann Allergy Asthma Immunol 2003 90 182 91.