Novel tethered particle motion analysis of CI protein-mediated DNA looping in the regulation of bacteriophage lambda

Journal of Physics Condensed Matter

Volumn 18, Issue 14, 2006, Pages

  Zurla, C ^a,d   Franzini, A ^a   Galli, G ^a,e   Dunlap, D D ^b   Lewis, D E A ^c   Adhya, S ^c   Finzi, L ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

^d EMORY UNIVERSITY   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGES; DATA ACQUISITION; DNA; MOLECULAR ORIENTATION; MOLECULAR STRUCTURE; MOTION ESTIMATION; NUCLEIC ACIDS; PROTEINS;

ANGULAR ORIENTATION; DNA LOOPING; MOTION ANALYSIS; TETHERED PARTICLE MOTION (TPM);

GENETIC ENGINEERING;

EID: 33645322437     PISSN: 09538984     EISSN: 1361648X     Source Type: Journal    
DOI: 10.1088/0953-8984/18/14/S07     Document Type: Article

References (10)

1. Finzi L and Gelles J 1995 Measurement of lactose-repressor mediated loop formation and breakdown in single DNA molecules Science 267 378
2. Blumberg S, Gajraj A, Pennington M W and Meiners J 2005 3-D characterization of tethered microspheres by total internal reflection fluorescence microscopy Biophys. J. 89 1272
3. Revet B, von Wilcken-Bergmann B, Bessert H, Barker A and Muller-Hill B 1999 Four dimers of a lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances Curr. Biol. 9 151
4. Little J W, Shepley D P and Wert D W 1999 Robustness of a gene regulatory circuit EMBO J. 18 4299
5. Ptashne M 2005 Regulation of transcription: from lambda to eukaryotes Trends Biochem. Sci. 30 275
6. Ptashne M 2004 A Genetic Switch: Phage Lambda Revisited 3rd edn (Cold Spring Harbor: Cold Spring Harbor Laboratory Press)
7. Dodd I B, Shearwin K E, Perkins A J, Burr T, Hochschild A and Egan J B 2004 Cooperativity in long-range gene regulation by the λ CI repressor Genes Dev. 18 344
8. Lewis D E A and Adhya S 2002 In vitro repression of the gal promoters by GalR and HU depends on the proper helical phasing of the two operators J. Biol. Chem. 277 2498
9. Finzi L and Dunlap D D 2003 Single molecule studies of DNA architectural changes induced by regulatory proteins Methods Enzymol. 370 369
10. Semsey S, Virnik K and Adhya S 2005 A gamut of loops: meandering DNA Trends Biochem. Sci. 30 334