Vertebral tumors: Surgical versus nonsurgical treatment

Clinical Orthopaedics and Related Research

Volumn 443, Issue , 2006, Pages 233-247

  Simmons, Edward D ^a   Zheng, Yinggang ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; MELPHALAN; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PAMIDRONIC ACID; PREDNISONE; PYROPHOSPHATE SM 153; PYROPHOSPHATE SR 89; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANEURYSMAL BONE CYST; ARTIFICIAL EMBOLISM; AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; BACKACHE; BONE DISEASE; BONE METASTASIS; BONE PAIN; BONE SCINTISCANNING; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER INCIDENCE; CANCER PAIN; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CHONDROSARCOMA; CHORDOMA; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; ENDOSCOPIC SURGERY; EOSINOPHILIC GRANULOMA; EWING SARCOMA; HEMANGIOMA; HISTOPATHOLOGY; HODGKIN DISEASE; HUMAN; KYPHOPLASTY; LABORATORY TEST; LAMINECTOMY; LYMPHOMA; MAINTENANCE THERAPY; MULTIMODALITY CANCER THERAPY; MULTIPLE MYELOMA; NEEDLE BIOPSY; NONHODGKIN LYMPHOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOCHONDROMA; OSTEOCLASTOMA; OSTEOID OSTEOMA; OSTEOSARCOMA; PATIENT SELECTION; PERCUTANEOUS VERTEBROPLASTY; PHYSICAL EXAMINATION; PLASMACYTOMA; POSITRON EMISSION TOMOGRAPHY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSTATE CARCINOMA; QUALITY OF LIFE; RADIOFREQUENCY ABLATION; SCOLIOSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPINAL ANGIOGRAPHY; SPINAL CORD COMPRESSION; SPINE INSTABILITY; SPINE METASTASIS; SPINE SURGERY; SPINE TUMOR; SURGICAL APPROACH; SURGICAL TECHNIQUE; TREATMENT CONTRAINDICATION; TREATMENT INDICATION; TREATMENT OUTCOME; TUMOR DIAGNOSIS; TUMOR LOCALIZATION; ADJUVANT THERAPY; DECISION MAKING; METHODOLOGY; ORTHOPEDIC SURGERY; REVIEW; SPINAL CORD TUMOR;

ANTINEOPLASTIC AGENTS; COMBINED MODALITY THERAPY; DECISION MAKING; HUMANS; ORTHOPEDIC PROCEDURES; RADIOTHERAPY, ADJUVANT; SPINAL NEOPLASMS;

EID: 33645317658     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/01.blo.0000198723.77762.0c     Document Type: Conference Paper

References (179)

1. Aebi M. Spinal metastasis in the elderly. Eur Spine J. 2003;12(Suppl 2):S202-S213.
2. Akbarnia BA, Rooholamini SA. Scoliosis caused by benign osteoblastoma of the thoracic and lumbar spine. J Bone Joint Surg. 1981;63:1146-1155.
3. Aprin H. Primary Malignant Tumors of the Spine. In: Akbarnia BA, ed. Spine: State of the art reviews. Vol. 2, No. 2, Spinal Tumors. Philadelphia, PA: Hanley & Belfus, Inc; 1988:289-299.
4. Asdourian PL. Metastatic Disease of the Spine. In: Bridwell KH, DeWald RL, eds. The Textbook of Spinal Surgery. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1997:2007-2050.
5. Avrahami E, Tadmor R, Dally O, et al. Early MR demonstration of spinal metastases in patients with normal radiographs and CT and radionuclide bone scans. J Comput Assist Tomogr. 1989;13:598-602.
6. Azzarelli A, Quagliuolo V, Cerasoli S, et al. Chordoma: natural history and treatment results in 33 cases. J Surg Oncol. 1988;37:185-191.
7. Baar J. Burkies Rl, Gospodarowicz M. Primary non-Hodgkin's lymphoma of bone. Semin Oncol. 1999;26:270-275.
8. Baba H, Maezawa Y, Furusawa N, et al. Solitary plasmacytoma of the spine associated with neurological complications. Spinal Cord. 1998;36:470-475.
9. Bacci G, Ferrari S, Longhi A, et al. Role of surgery in local treatment of Ewing's sarcoma of the extremities in patients undergoing adjuvant and neoadjuvant chemotherapy. Oncol Rep. 2004;11:111-120.
10. Bacci G, Savini R, Calderoni P, et al. Solitary plasmacytoma of the vertebral column. A report of 15 cases. Tumori. 1982;68:271-271.
11. Baker ND, Klein MJ, Greenspan A. Symptomatic vertebral hemangiomas: a report of four cases. Skeletal Radiol. 1986;15:458-463.
12. Barron KD, Hirano A, Araki S. Experience with metastatic neoplasms involving the spinal cord. Neurology. 1959;9:91.
13. Bartels RH, Grotenhui JA, Van Der Spek JA. Symptomatic vertebral hemangiomas. J Neurosurg Sci. 1991;35:187-192.
14. Bataille R, Sany J. Solitary myeloma: clinical and prognostic features of a review of 114 cases. Cancer. 1981;48:845-851.
15. Bergh P, Gunterberg B, Meis-Kindblom JM, Kindblom LG. Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases. Cancer. 2001;91:1201-1212.
16. Bergh P, Kindblom LG, Gunterberg B, et al. Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer. 2000;88:2122-2134.
17. Black P. Spinal metastasis: current status and recommended guideline for management. Neurosurgery. 1979;5:726-746.
18. Body JJ. Metastatic bone disease: Clinical and therapeutic aspects. Bone. 1992;13:S57-S62.
19. Boriani S, Biagini R, Bandiera S, Gasbarrini A, De LF. Reconstruction of the anterior column of the thoracic and lumbar spine with a carbon fiber stackable cage system. Orthopedics. 2002;25:37-42.
20. Boriani S, De Iure F, Bandiera S, et al. Chondrosarcoma of the mobile spine: report on 22 cases. Spine. 2000;25:804-812.
21. Bradway JK, Pritchard DJ. Ewing's Tumor of the Spine. In: Sundaresan N, Schmidek HH, Schiller AL, Rosenthal DI, eds. Tumors of the Spine: Diagnosis and clinical Management. Philadelphia, PA: WB Saunders; 1990:235-239.
22. Brice J, McKissock W. Surgical treatment of malignant extradural spinal tumors. BMJ. 1965;1:1341.
23. Broaddus WC, Grady MS, Delashaw JB Jr, Ferguson RD, Jane JA. Preoperative superselective arteriolar embolization: a new approach to enhance resectability of spinal tumors. Neurosurgery. 1990;27:755-759.
24. Byrne TN. Spinal cord compression from epidural metastases. N Engl J Med. 1992;327:614-619.
25. Byrne TN. Metastatic epidural cord compression. Curr Neurol Neurosci Rep. 2004;4:191-195.
26. Campanacci M, Baldini N, Boriani S, et al. Giant Cell tumor of bone. J Bone Joint Surg. 1987;69:106-113.
27. Campanacci M, Boriani S, Giunti A. Giant Cell Tumors of the Spine. In: Sundaresan N, Schmidek HH, Schiller AL, Rosenthal DI, eds. Tumors of the Spine: Diagnosis and Clinical Management. Philadelphia, PA: W.B. Saunders; 1990:163-172.
28. Campanacci M. Giant Cell Tumor. In: Gaggi A, ed. Bone and Soft-Tissue Tumors. Bologna, Italy: Springer-Verlag; 1990:117-1531.
29. Cantwell CP, Obyrne J, Eustace S. Current trends in treatment of osteoid osteoma with an emphasis on radiofrequency ablation. Eur Radiol. 2003;14:607-617.
30. Capanna R, Albisinni U, Picci P, et al. Aneurysmal bone cyst of the spine. J Bone Joint Surg. 1985;67:527-531.
31. Caro PA, Mandell GA, Stanton RP. Aneurysmal bone cyst of the spine in children. MRI imaging at 0.5 tesla. Pediatr Radiol. 1991;21:114-116.
32. Cioni R, Armillotta N, Bargellini I, et al. CT-guided radiofrequency ablation of osteoid osteoma: long-term results. Eur Radiol. 2004;14:1203-1208.
33. Compere EL, Johnson WE, Coventry MB. Vertebra plana (Calve's disease) due to eosinophilic granuloma. J Bone Joint Surg. 1954;36:969-980.
34. Constans JP, de Devitis E, Conzelli R, et al. Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg. 1983;59:111-118.
35. Corwin J, Lindberg RD. Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer. 1979;43:1007-1013.
36. Cove JA, Taminiau AH, Obermann WR, Vanderschueren GM. Osteoid osteoma of the spine treated with percutaneous computed tomography-guided thermocoagulation. Spine. 2000;25:1283-2386.
37. Dahlin DC, Coventry MB. Osteosarcoma: a study of 600 cases. J Bone Joint Surg. 1967;49:101-110.
38. Dahlin DC, Unni KK. Chordoma. Arch Pathol Lab Med. 1994;118:596-597.
39. Dahlin DC, Unni KU, eds. Bone Tumors, General Aspects, and Data on 8542 Cases. 4th ed. Springfield, IL: Charles C Thomas; 1986.
40. de Camargo OP, dos Santos Machado TM, Croci AT, et al. Primary bone lymphoma in 24 patients treated between 1955 and 1999. Clin Orthop Relat Res. 2002;397:271-280.
41. Dickinson LD, Farhat SM. Eosinophilic granuloma of the cervical spine. A case report and review of the literature. Surg Neurol. 1991;35:57-63.
42. Doita M, Harada T, Iguchi T, Sumi M, Sha H, Yoshiya S, Kurosaka M. Total sacrectomy and reconstruction for sacral tumors. Spine. 2003;28:E296-E301.
43. Dreghorn C, Newman R, Hardy G, et al. Primary tumors of the axial skeleton: Experience of Leeds Regional Bone Tumor Registry. Spine. 1990;15:137-140.
44. Dudeney S, Lieberman IH, Reinhardt MK, Hussein M. Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol. 2002;20:2382-2387.
45. Dunn RC Jr, Kelly WA, Wohns RNW, et al. Spinal epidural neoplasis: A 15-year review of the results of surgical therapy. J Neurosurg. 1980;52:47-51.
46. Enneking WF. Spine. In: Enneking WF, ed. Musculoskeletal Tumor Surgery. New York, NY: Churchill Livingstone; 1983:303-354.
47. Ewing J. Diffuse endothelioma of bone. Proc NY Pathol Soc. 1921;21:17-22.
48. Fidias P, Spiro I, Sobczak ML, et al. Long-term results of combined modality therapy in primary bone lymphomas. Int J Radiat Oncol Biol Phys. 1999;45:1213-1218.
49. Fielding JW, Pyle RN Jr, Fietti VG Jr. Anterior cervical vertebral body resection and bone grafting for benign and malignant tumors. A survey under the auspices of the Cervical Spine Research Society. J Bone Joint Surg. 1979;61:251-253.
50. Fourney DR, Schomer DF, Nader R, et al. Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg. 2003;98(1 Suppl):21-30.
51. Fuchs B, Valenzuela RG, Petersen IA, Arndt CA, Sim FH. Ewing's sarcoma and the development of secondary malignancies. Clin Orthop Relat Res. 2003;415:82-89.
52. Galasko CS, Doyle FH. The detection of skeletal metastases from mammary cancer. A regional comparison between radiology and scintigraphy. Clin Radiol. 1972;23:295-297.
53. Galasko CSB. Diagnosis of skeletal metastases and assessment of response to treatment. Clin Orthop Relat Res. 1995;312:64-75.
54. Galasko CS. Incidence and distribution of skeletal metastases. In: Galasko CSB ed. Skeletal Metastases. London, England: Butterworths; 1986:14-21.
55. Gates GF. SPECT bone scanning of the spine. Semin Nucl Med. 1998;28:78-94.
56. Gelb DE, Bridwell KH. Benign Tumors of the Spine. In: Bridwell KH, DeWald RL, eds. The Textbook of Spinal Surgery. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1997:1959-1981.
57. Gerszten PC, Ozhasoglu C, Burton SA, et al. CyberKnife frameless stereotactic radiosurgery for spinal lesions: Clinical experience in 125 cases. Neurosurgery. 2004;55:89-98.
58. Ghogawala Z, Mansfield FL, Borges LF. Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression. Spine. 2001;26:818-824.
59. Gibbs IC, Chang SD. Radiosurgery and radiotherapy for sacral tumors. Available at: http://www.medscape.com/viewarticle/461099. Accessed August, 2004.
60. Gokaslan ZL, Romsdahl MM, Kroll SS, et al. Total sacrectomy and Galveston L-rod reconstruction for malignant neoplasms. Technical note. J Neurosurg. 1997;87:781-787.
61. Goodman MA. Plasma cell tumors. Clin Orthop Relat Res. 1986;204:86-92.
62. Goorin AM, Abelson HT, Frei E III. Osteosarcoma: Fifteen years later. N Engl J Med. 1985;313:1637-1643.
63. Gottfried ON, Schmidt MH, Stevens EA. Embolization of sacral tumors. Available at: http://www.medscape.com/viewarticle/461095. Accessed August, 2004.
64. Griffin JB. Benign osteoblastoma of the thoracic spine. J Bone Joint Surg. 1978;60:833-835.
65. Guibaud L, Herbreteau D, Dubois J, Stempfle N, Berard J, Pracros JP, Merland JJ. Aneurysmal bone cysts: Percutaneous embolization with an alcoholic solution of zein - series of 18 cases. Radiology. 1998;208:369-373.
66. Hadjipavlou AG, Lander PH, Marchesi D, Katonis PG, Gaitanis IN. Minimally invasive surgery for ablation of osteoid osteoma of the spine. Spine. 2003;28:E472-E477.
67. Harrington KD. Metastatic disease of the spine. J Bone Joint Surg. 1986;68:1110-1115.
68. Harrington KD. The use of methylmethacrylate for vertebral body replacement and anterior stabilization of pathological fracture-dislocations of the spine due to metastatic malignant disease. J Bone Joint Surg. 1981;63:36-46.
69. Hart RA, Boriani S, Biagini R, et al. A system for surgical staging and management of spine tumors: A clinical outcome study of giant cell tumors of the spine. Spine. 1997;22:1773-1778.
70. Hay MC, Paterson D, Taylor TKF. Aneurysmal bone cysts of the spine. J Bone Joint Surg. 1978;60:406-411.
71. Healey JH, Ghelman B. Osteoid osteoma and osteoblastoma: Current concepts and recent advances. Clin Orthop Relat Res. 1986;204:76-85.
72. Heary RF. Bono CM. Metastatic spinal tumors. Available at: http://www.medscape.com/viewarticle/421498. Accessed August, 2004.
73. Henderson ED, Dahlin DC. Chondrosarcoma of bone: A study of 288 cases. J Bone Joint Surg. 1963;45:1450-1458.
74. Higinbotham NL, Philips RF, Farr HW, et al. Chordoma: thirty-five year study at Memorial Hospital. Cancer. 1967;20:1841-1850.
75. Hirabayashi H, Ebara S, Kinoshita T, Yuzawa Y, Nakamura I, Takahashi J, Kamimura M, Ohtsuka K, Takaoka K. Clinical outcome and survival after palliative surgery for spinal metastases: palliative surgery in spinal metastases. Cancer. 2003;97:476-484.
76. Hudson TM. Radionuclide bone scanning of medullary chondrosarcoma. AJR Am J Roentgenol. 1982;139:1071-1076.
77. Huvos AG. Bone Tumors: Diagnosis, Treatment, and Prognosis. Philadelphia, PA: W.B. Saunders Co; 1979.
78. Jacobs WB, Perrin RG. Evaluation and treatment of spinal metastases: An overview. Available at: . Accessed
79. Jacobson JG, Poppel MH, Shapiro JH, et al. The vertebral pedicle sign. AJR Am Roentgenol. 1958;80:817.
80. Janin Y, Epstein JA, Carras R, et al. Osteoid osteomas and osteoblastomas of the spine. Neurosurgery. 1981;8:31-38.
81. Janjan N. Bone metastases: approaches to management. Semin Oncol. 2001;28:28-34.
82. Joo KG, Parthasarathy KL, Bakshi SP, et al. Bone scintigrams: Their clinical usefulness in patients with breast carcinoma. Oncology. 1979;36:94-98.
83. Kager L, Zoubek A, Potschger U, et al. Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. J Clin Oncol. 2003;21:2011-2018.
84. Kaiser TE, Pritchard DJ, Unni KK. Clinicopathologic study of sacrococcygeal chordoma. Cancer. 1984;54:2574-2578.
85. Katagiri H, Takahashi M, Inagaki J, et al. Clinical results of nonsurgical treatment for spinal metastases. Int J Radiat Oncol Biol Phys. 1998;42:1127-1132.
86. Kawai A, Huvos AG, Meyers PA, Healey JH. Osteosarcoma of the pelvis: oncologic results of 40 patients. Clin Orthop Relat Res. 1998;348:196-207.
87. Kim SH, Lim SK, Hahn JS. Effect of pamidronate on new vertebral fractures and bone mineral density in patients with malignant lymphoma receiving chemotherapy. Am J Med. 2004;116:524-528.
88. Kjaer M, Engelholm SA. The clinical course and prognosis of patients with renal adenocarcinoma with solitary metastasis. Int J Radiat Oncol Biol Phys. 1982;8:1691-1698.
89. Kornberg M. Erythrocyte sedimentation rate following lumbar discectomy. Spine. 1986;11:766-767.
90. Kyle RA. Current therapy of multiple myeloma. Intern Med. 2002;41:175-180.
91. Kyle RA. Multiple Myeloma. Diagnostic challenges and standard therapy. Semin Hematol. 2001;38:11-14.
92. Kyle RA. Multiple myeloma: Review of 869 cases. Mayo Clin Proc. 1975;50:29.
93. Lane JM, Hong R, Koob J, et al. Kyphoplasty enhances function and structural alignment in multiple myeloma. Clin Orthop Relat Res. 2004;426:49-53.
94. Lane JM, Hurson B, Boland PJ, et al. Osteogenic sarcoma. Clin Orthop Relat Res. 1986;204:93-110.
95. Lane JM. Malignant Bone Tumors. In: Alfonson AE, Cardner E, eds. The Practice of Cancer Surgery. New York, NY: Appleton-Century-Crofts; 1982:307-324.
96. Lang EK, Sullivan J. Management of primary and metastatic renal cell carcinoma by transcatheter embolization with iodine 125. Cancer. 1988;62:274-282.
97. Lang P, Johnston JO, Arenal-Romero F, et al. Advances in MR imaging of pediatric musculoskeletal neoplasms. Magn Reson Imaging Clin N Am. 1998;6:579-604.
98. Levine AM, Crandall DG. Treatment of Primary Malignant Tumors of the spine and Sacrum. In: Bridwell KH, DeWald RL, eds. The Textbook of Spinal Surgery. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1997:1938-2006.
99. Leviov M, Dale J, Stein M, et al. The management of metastatic spinal cord compression: A radiotherapeutic success ceiling. Int J Radiat Oncol Biol Phys. 1993;27:231-234.
100. Lieberman I, Reinhardt MK. Vertebroplasty and kyphoplasty for osteolytic vertebral collapse. Clin Orthop Relat Res. 2003;415(Suppl):S176-S186.
101. Lin PP, Guzel VB, Moura MF, et al. Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolization. Cancer. 2002;95:1317-1325.
102. Livingston KE, Perrin RG. The neurosurgical management of spinal metastases causing cord and cauda equina compression. J Neurosurg. 1978;49:839-843.
103. MacDonald DR. Clinical Manifestations. In: Sundaresan N, Schmidek HH, Schiller AL, Rosenthal DI, eds. Tumors of the Spine: Diagnosis and Clinical Management. Philadelphia, PA: WB Saunders; 1990:6-21.
104. Makley JT, Carter JR. Eosinophilic granuloma of bone. Clin Orthop Relat Res. 1986;204:37-44.
105. Manke C, Bretschneider T, Lenhart M, et al. Spinal metastases from renal cell carcinoma: effect of preoperative particle embolization on intraoperative blood loss. AJNR Am J Neuroradiol. 2001;22:997-1003.
106. Maranzano E, Latini P. Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial. Int J Radiat Oncol Biol Phys. 1995;32:959-967.
107. Marcus RB Jr, Berrey BH, Graham-Pole J, Mendenhall NP, Scarborough MT. The treatment of Ewing's sarcoma of bone at the University of Florida: 1969 to 1998. Clin Orthop Relat Res. 2002;397:290-297.
108. McLain radiofrequency. Weinstein JN. Solitary plasmacytomas of the spine: a review of 84 cases. J Spinal Dis. 1989;2:69-74.
109. McLain Radiofrequency. Weinstein JN. Tumors of the spine. Semin Spine Surg. 1990;2:157-180.
110. McLeod RA, Dahlin DC, Beabout JW. The spectrum of osteoblastoma. AJR Am J Roentgenol. 1976;126:321-325.
111. McQueen multiple myeloma, Chalmers J, Smith GD. Spontaneous healing of aneurysmal bone cysts. A report of two cases. J Bone Joint Surg Br. 1985;67:310-312.
112. Meislin RJ, Neuwirth MG, Bloom ND. Tumors of the Thoracolumbar Spine. In: Lewis MM, ed. Musculoskeletal Oncology: A Multidisciplinary Approach. Philadelphia, PA: W. B. Saunders; 1992:227-241.
113. Merenda JT. Other Primary Benign Tumors and Tumor-Like Lesions of the Spine. In: Akbarnia BA, ed. Spine: State of the Art Reviews, Vol. 2, No. 2, Spinal Tumors. Philadelphia, PA: Hanley & Belfus, Inc; 1988:275-287.
114. Mirra JM. Bone Tumors: Diagnosis and Treatment. Philadelphia, PA: J.B. Lippincott; 1980.
115. Nesbit ME, Kieffer S, D'Angio GJ. Reconstruction of vertebral height in histiocytosis X: A long-term followup. J Bone Joint Surg. 1969;51:1360-1368.
116. Nguyen JP, Djindjian M, Gaston A, et al. Vertebral hemangiomas presenting with neurologic symptoms. Surg Neurol. 1987;27:391-397.
117. Novick GS, Pavlov H, Bullough PG. Osteochondroma of cervical spine: Case reports. Skeletal Radiol. 1982;8:13-15.
118. Oberlin O, Patte C, Demeocq F, et al. The response to initial chemotherapy as prognostic factor in localized Ewing's sarcoma. Eur J Cancer Clin Oncol. 1985;21:463-467.
119. Osti OL, Sebben R. High-frequency radio-wave ablation of osteoid osteoma in the lumbar spine. Eur Spine J. 1998;7:422-425.
120. Ostrowsky ML, Unni KK, Banks PM, et al. Malignant lymphoma of bone. Cancer. 1986;58:2646-2655.
121. Ozaki T, Flege S, Kevric M, et al. Osteosarcoma of the pelvis: experience of the Cooperative Osteosarcoma Study Group. J Clin Oncol. 2003;21:334-341.
122. Ozaki T, Halm H, Hillmann A, Blasius S, Winkelmann W. Aneurysmal bone cysts of the spine. Arch Orthop Trauma Surg. 1999;119:159-162.
123. Ozaki T, Liljenqvist U, Halm H, Hillmann A, Gosheger G, Winkelmann W. Giant cell tumor of the spine. Clin Orthop Relat Res. 2002;401:194-201.
124. Papagelopoulos PJ, Choudhury SN, Frassica FJ, et al. Treatment of aneurysmal bone cysts of the pelvis and sacrum. J Bone Joint Surg. 2001;83:1674-1681.
125. Patchell R, Tibbs PA, Regine WF, et al. A randomized trial of direct decompressive surgical resection in the treatment of spinal cord compression caused by metastasis. Proc Am Soc Clin Oncol. 2003;22:1.
126. Paulussen M, Ahrens S, Dunst J, et al. Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86. J Clin Oncol. 2001;19:1818-1829.
127. Paulussen M, Frohlich B, Jurgens H. Ewing tumour: incidence, prognosis and treatment options. Paediatr Drugs. 2001;3:899-913.
128. Rajkumar SV, Gertz MA, Kyle RA, et al. Current therapy for multiple myeloma. Mayo Clin Proc. 2002;77:813-822.
129. Roberts JG, Gravelle IH, Baum M, et al. Evaluation of radiography and isotopic scintigraphy for detecting skeletal metastases in breast cancer. Lancet. 1976;1:237-239.
130. Rompe JD, Hopf CG, Eysel P. Outcome after palliative posterior surgery for metastatic disease of the spine - evaluation of 106 consecutive patients after decompression and stabilisation with the Cotrel-Dubousset instrumentation. Arch Orthop Trauma Surg. 1999;119:394-400.
131. Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology. 2003;229:171-175.
132. Ruff SJ, Taylor TKF, Nicholson OR. Eosinophilic granuloma of the spine. J Bone Joint Surg. 1984;66:780.
133. Saglik Y, Kapicioglu MI, Guzel B. Spontaneous regression of aneurysmal bone cyst. A case report. Arch Orthop Trauma Surg. 1993;112:203-204.
134. Samson IR, Springfield DS, Suit HD, et al. Operative treatment of sacrococcygeal chordoma. A review of 21 cases. J Bone Joint Surg. 1993;75:1476-1484.
135. Schajowicz F. Tumors and Tumor Like Lesions of Bone and Joints. New York, NY: Springer-Verlag; 1981.
136. Schuster JM, Grady MS. Medical management and adjuvant therapies in spinal metastatic disease. Available at: http://www.medscape.com/viewarticle/ 421503. Accessed August, 2004.
137. Scott I, Connell DG, Duncan CP. Regression of aneurysmal bone cyst following open biopsy. Can Assoc Radiol J. 1986;37:198-200.
138. Serafini AN. Systemic metabolic radiotherapy with samarium-153 EDTMP for the treatment of painful bone metastasis. Q J Nucl Med. 2001;45:91-99.
139. Sherk HH, Nicholson JT, Nixon JE. Vertebra plana and eosinophilic granuloma of the cervical spine in Children. Spine. 1978;3:116-121.
140. Sheth DS, Yasko AW, Johnson ME, Ayala AG, Murray JA, Romsdahl MM. Chondrosarcoma of the pelvis. Prognostic factors for 67 patients treated with definitive surgery. Cancer. 1996;78:745-750.
141. Shives TC, Dahlin DC, Sim FH, et al. Osteosarcoma of the spine. J Bone Joint Surg. 1986;68:660-668.
142. Silberstein MJ, Sundaram M, Akbarnia B, et al. Eosinophilic granuloma of the spine. Orthopedics. 1985;8:264, 267-274.
143. Silverberg E, Lubera JA. Cancer Statistics, 1989. CA Cancer J Clin. 1989;39:3-20.
144. Sinar EJ, Maurice-Williams RS. Spinal extradural tumours mimicking a lumbar disc protrusion. J R Coll Surg Edinb. 1987;32:179-180.
145. Smit JW, Vielvoye GJ, Goslings BM. Embolization for vertebral metastases of follicular thyroid carcinoma. J Clin Endocrinol Metab. 2000;85:989-994.
146. Smith TP, Koci T, Mehringer CM, et al. Transarterial embolization of vertebral hemangioma. J Vasc Interv Radiol. 1993;4:681-685.
147. Steinmetz MP, Mekhail A, Benzel EC. Management of metastatic tumors of the spine: strategies and operative indications. Available at: http://www.medscape.com/viewarticle/421499. Accessed August, 2004.
148. Stener B, Gunterberg B. High amputation of the sacrum for extirpation of tumors. Principles and technique. Spine. 1978;3:351-366.
149. Sundaresan N, Krol G, Digiacinto GV. Metastatic Tumors of the Spine. In: Sundaresan N, Schmidek HH, Schiller AL, Rosenthal DI, eds. Tumors of the Spine: Diagnosis and Clinical Management. Philadelphia, PA: W.B. Saunders; 1990:279-304.
150. Sundaresan N, Scher H, DiGiacinto GV, Yagoda A, Whitmore W, Choi IS. Surgical treatment of spinal cord compression in kidney cancer. J Clin Oncol. 1986;4:1851-1856.
151. Sundaresan N. Chordomas. Clin Orthop Relat Res. 1986;204:135-142.
152. Sweriduk ST, DeLuca SA. The sclerotic pedicle. Am Fam Physician. 1987;35:161-162.
153. Sypert GW. Osteoid osteoma and osteoblastoma of the spine. In: Sundaresan N, Takahashi T, Koshu K, Tominaga T, Takahashi A, Yoshimoto T. Solitary plasmacytoma in the thoracic spine. Two case reports. Neurosurg Rev. 1998;21:121-125.
154. Talac R, Yaszemski MJ, Currier BL, et al. Relationship between surgical margins and local recurrence in sarcomas of the spine. Clin Orthop Relat Res. 2002;397:127-132.
155. Terpos E, Rahemtulla A. Bisphosphonate treatment for multiple myeloma. Drugs Today (Barc). 2004;40:29-40.
156. Todd LT Jr, Yaszemski MJ, Currier BL, Fuchs B, Kim CW, Sim FH. Bowel and bladder function after major sacral resection. Clin Orthop Relat Res. 2002;397:36-39.
157. Treves ST, Kirkpatrick JA. Bone. In: Treves ST, ed. Pediatric Nuclear Medicine. New York, NY: Springer-Verlag; 1985.
158. Turcotte RE, Sim FH, Unni KK. Giant cell tumor of the sacrum. Clin Orthop Relat Res. 1993;291:215-221.
159. Turcotte RE, Wunder JS, Isler MH, et al. Giant cell of long bone: A Canadian sarcoma group study. Clin Orthop Relat Res. 2002;397:248-258.
160. Turner SL, Gruenewald S, Spry N, Gebski V. Metastron Users Group. Less pain does equal better quality of life following strontium-89 therapy for metastatic prostate cancer. Br J Cancer. 2001;84:297-302.
161. Vassalo J, Roessner A, Vollmer E, et al. Malignant lymphoma with primary bone manifestation. Pathol Res Pract. 1987;182:381-389.
162. Venkateswaran L, Rodriguez-Galindo C, Merchant TE, et al. Primary Ewing tumor of the vertebrae: clinical characteristics, prognostic factors, and outcome. Med Pediatr Oncol. 2001;37:30-35.
163. Villas C, Martinez-Peric R, Barrios RH, et al. Eosinophilic granuloma of the spine with and without vertebra plana: Long-term follow-up of six cases. J Spinal Disord. 1993;6:260-268.
164. Vrionis FD, Small J. Surgical management of metastatic spinal neoplasms. Available at: http://www.medscape.com/viewarticle/465374. Accessed August, 2004.
165. Wai EK, Finkelstein JA, Tangente RP, et al. Quality of life in surgical treatment of metastatic spine disease. Spine. 2003;28:508-512.
166. Walker DR, Rankin RN, Anderson C, et al. Giant-cell tumour of the sacrum in a child. Can J Surg. 1988;31:47-49.
167. Walsh GL, Gokaslan ZL, McCutcheon IE, Mineo MT, Yasko AW, Swisher SG, Schrump DS, Nesbitt JC, Putnam JB Jr, Roth JA. Anterior approaches to the thoracic spine in patients with cancer: indications and results. Ann Thorac Surg. 1997;64:1611-1618.
168. Weigel B, Maghsudi M, Neumann C, Kretschmer R, Muller FJ, Nerlich M. Surgical management of symptomatic spinal metastases. Postoperative outcome and quality of life. Spine. 1999;24:2240-2246.
169. Weinstein JN, Collalto P, Lehmann TR. Long-term follow-up of nonoperative treated thoracolumbar spine fractures. J Orthop Trauma. 1988;3:152-159.
170. Weinstein JN. McLain Radiofrequency. Tumors of the Spine. In: Rothman RH, Simeone FA, eds. The Spine. 3rd ed. Philadelphia, PA: W.B. Saunders; 1992:1279-1318.
171. Willis RA. Secondary Tumors of Bones. In: The Spread of Tumors in the Human Body. 3rd ed. London, England: Butterworth; 1972:229.
172. Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone in myelomatosis. Medicine (Baltimore). 1976;55:217-238.
173. Witte RJ, Miller GM. Spine. In: Berquist TH, ed. MRI of the Musculoskeletal System. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001:143-194.
174. Worlock P, Clifford P. Aneurysmal bone cyst of the sacrum. J R Coll Surg Edinb. 1985;30:196-199.
175. Wu KK. Diagnosis and treatment of benign and malignant monostotic tumors of the spine. Detroit, MI: National Production Corporation, 1985.
176. Yasko AW, Chow W. Bone Sarcoma. In: Pazdur R, Coia LR, Hoskins WJ, et al, eds. Cancer Management: A Multidisciplinary Approach. 8th ed. Philadelphia, PA: F.A. Davis Company; 2004:549-560.
177. York JE, Kaczaraj A, Abi-Said D, Fuller GN, Skibber JM, Janjan NA, Gokaslan ZL. Sacral chordoma: 40-year experience at a major cancer center. Neurosurgery. 1999;44:74-79.
178. Young radiofrequency. Post EM, King GA. Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. J Neurosurg. 1980;53:741-748.
179. Zinzani PL, Carrillo G, Ascani S, et al. Primary bone lymphoma: Experience with 52 patients. Haematologica. 2003;88:280-285.