Synthesis and molecular modelling of novel substituted-4,5-dihydro-(1H)- pyrazole derivatives as potent and highly selective monoamine oxidase-A inhibitors

Chemical Biology and Drug Design

Volumn 67, Issue 3, 2006, Pages 206-214

  Chimenti, Franco ^a   Bolasco, Adriana ^a   Manna, Fedele ^a   Secci, Daniela ^a   Chimenti, Paola ^a   Granese, Arianna ^a   Befani, Olivia ^a   Turini, Paola ^a   Alcaro, Stefano ^b   Ortuso, Francesco ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

(1H) pyrazole derivatives; Molecular modelling; Monoamine oxidase; Reversible monoamine oxidase A inhibitors; Selective monoamine oxidase A inhibitors

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ISOENZYME; MONOAMINE OXIDASE INHIBITOR; PYRAZOLE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; SUBSTITUTION REACTION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PYRAZOLES;

EID: 33645314648     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2006.00367.x     Document Type: Article

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