History of gastric carcinoma research in Japan: Basic aspects

The Diversity of Gastric Carcinoma: Pathogenesis, Diagnosis, and Therapy

Volumn , Issue , 2005, Pages 3-28

  Tatematsu, Masae ^a   Tsukamoto, Tetsuya ^a   Mizoshita, Tsutomu ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33645309715     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/4-431-27713-7_1     Document Type: Chapter

References (226)

1. Oettle AG (1955) Spontaneous carcinoma of the glandular stomach in a laboratory stock of Rattus (Mastomys) natalensis. S Afr J Med Sci 20:36
2. Oettle AG (1957) Spontaneous carcinoma of the glandular stomach in Rattus (mastomys) natalensis, an African rodent. Br J Cancer 11:415-433
3. Snell KC, Stewart HL (1969) Malignant argyrophilic gastric carcinoids of Praomys (Mastomys) natalensis. Science 163:470
4. Rusch HP, Baumann, CA, Maison GL (1940) Production of internal tumors with chemical carcinogens. Arch Pathol 29:8-19
5. Stewart HL, Snell KC (1958) Histopathogenesis of carcinoma induced in the glandular stomach of C57BL mice by the intramural injection of 20-methylcholanthrene. J Natl Cancer Inst 21:999-1035
6. Wilson RH, De Eds F, Cox AJ Jr (1941) The toxicity and carcinogenic activity of 2-acetaminofluorene. Cancer Res 1:595-608
7. Sugimura T, Fujimura S (1967) Tumour production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine. Nature (Lond) 216:943-944
8. Fujimura S, Kogure K, Oboshi S, et al (1970) Production of tumors in glandular stomach of hamsters by N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res 30:1444-1448
9. Kogure K, Sasadaira H, Kawachi T, et al (1974) Further studies on induction of stomach cancer in hamsters by N-methyl-N'-nitro-N-nitrosoguanidine. Br J Cancer 29:132-142
10. Sugimura T, Tanaka N, Kawachi T, et al (1971) Production of stomach cancer in dogs by N-methyl-N'-nitro-N-nitrosoguanidine. Gann 62:67
11. Takahashi M, Sato H (1969) Effect of 4-nitroquinoline 1-oxide with alkylbenzenesulfonate on gastric carcinogenesis in rats. Gann Monogr 8:241-261
12. Takahashi M (1970) Effect of alkylbenzenesulfonate as a vehicle for 4-nitroquinoline 1-oxide on gastric carcinogenesis in rats. Gann 61:27-33
13. Sugimura T, Kawachi T (1976) Experimental gastric cancer (author's transl). Leber Magen Darm 6:80-90
14. Kurihara M, Shirakabe H, Murakami T, et al (1974) A new method for producing adenocarcinomas in the stomach of dogs with N-ethyl-N'-nitro-N- nitrosoguanidine. Gann 65:163-177
15. Mori K (1967) Carcinoma of the glandular stomach of mce by instillation of 4-nitroquinoline 1-oxide. Gann 58:389-393
16. Mori K, Ohta A (1967) Carcinoma of the glandular stomach of mice induced by 4-hydrox-yaminoquinoline 1-oxide. Gann 58:551-554
17. Sugimura T, Kawachi T (1973) In: Busch H (ed) Methods in cancer research, vol VII. Academic Press. New York, pp 245-308
18. Tatematsu M, Ogawa K, Hoshiya T, et al (1992) Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn J Cancer Res 83: 915-918
19. Tatematsu M, Yamamoto M, Iwata H, et al (1993) Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water. Jpn J Cancer Res 84:1258-1264
20. Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet i:1273-1275
21. Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311-1315
22. Hu PJ, Li YY, Zhou MH, et al (1995) Helicobacter pylori associated with a high prevalence of duodenal ulcer disease and a low prevalence of gastric cancer in a developing nation. Gut 36:198-202
23. Craanen ME, Dekker W, Blok P, et al (1992) Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum. Gut 33:16-20
24. Parsonnet J, Friedman GD, Vandersteen DP, et al (1991) Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127-1131
25. Nomura A, Stemmermann GN, Chyou PH, et al (1991) Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 325:1132-1136
26. Forman D, Newell DG, Fullerton F, et al (1991) Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ 302:1302-1305
27. Graham DY, Lew GM, Klein PD, et al (1992) Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. A randomized, controlled study. Ann Intern Med 116:705-708
28. Kuipers EJ, Uyterlinde AM, Pena AS, et al (1995) Long-term sequelae of Helicobacter pylori gastritis. Lancet 345:1525-1528
29. Asaka M, Kato M, Kudo M, et al (1996) Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging: studies in asymptomatic Japanese adults. Helicobacter 1:52-56
30. Huang JQ, Sridhar S, Chen Y, et al (1998) Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 114:1169-1179
31. Parsonnet J, Hansen S, Rodriguez L, et al (1994) Helicobacter pylori infection and gastric lymphoma. N Engl J Med 330:1267-1271
32. The EUROGAST Study Group (1993) An international association between Helicobacter pylori infection and gastric cancer. Lancet 341:1359-1362
33. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1994) Schistosomes, liver flukes and Helicobacter pylori. In: IARC Monographs on the evaluation of carcinogenic risks to humans, vol 61. IARC, Lyons, pp 1-241
34. Krakowka S, Morgan DR, Kraft WG, et al (1987) Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet. Infect Immun 55:2789-2796
35. Radin MJ, Eaton KA, Krakowka S, et al (1990) Helicobacter pylori gastric infection in gnotobiotic beagle dogs. Infect Immun 58:2606-2612
36. Lee A, Fox JG, Otto G, et al (1990) A small animal model of human Helicobacter pylori active chronic gastritis. Gastroenterology 99:1315-1323
37. Karita M, Kouchiyama T, Okita K, et al (1991) New small animal model for human gastric Helicobacter pylori infection: success in both nude and euthymic mice. Am J Gastroenterol 86:1596-1603
38. Karita M, Li Q, Cantero D, et al (1994) Establishment of a small animal model for human Helicobacter pylori infection using germ-free mouse. Am J Gastroenterol 89:208-213
39. Marchetti M, Arico B, Burroni D, et al (1995) Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science 267:1655-1658
40. Fox JG, Li X, Cahill RJ, et al (1996) Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology 110: 155-166
41. Hirayama F, Takagi S, Yokoyama Y, et al (1996) Establishment of gastric Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol 31(suppl 9):24-28
42. Tatematsu M, Yamamoto M, Shimizu N, et al (1998) Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine in drinking water. Jpn J Cancer Res 89:97-104
43. Sugiyama A, Maruta F, Ikeno T, et al (1998) Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil. Cancer Res 58:2067-2069
44. Shimizu N, Inada K, Nakanishi H, et al (1999) Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens. Carcinogenesis (Oxf) 20:669-676
45. Shimizu N, Inada KI, Tsukamoto T, et al (1999) New animal model of glandular stomach carcinogenesis in Mongolian gerbils infected with Helicobacter pylori and treated with a chemical carcinogen. J Gastroenterol 34(suppl 11):61-66
46. Stemmermann GN, Hayashi T (1968) Intestinal metaplasia of the gastric mucosa: a gross and microscopic study of its distribution in various disease states. J Natl Cancer Inst 41:627-634
47. Morson BC (1955) Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa. Br J Cancer 9:377-385
48. Correa P (1992) Human gastric carcinogenesis: a multistep and multifactorial process: First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52:6735-6740
49. You WC, Blot WJ, Li JY, et al (1993) Precancerous gastric lesions in a population at high risk of stomach cancer. Cancer Res 53:1317-1321
50. Yuasa Y (2003) Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer 3:592-600
51. Kawachi T, Kogure K, Tanaka N, et al (1974) Studies of intestinal metaplasia in the gastric mucosa by detection of disaccharidases with "Tes-Tape." J Natl Cancer Inst 53:19-30
52. Matsukura N, Suzuki K, Kawachi T, et al (1980) Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation to complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J Natl Cancer Inst 65:231-240
53. Teglbjaerg PS, Nielsen HO (1978) "Small intestinal type" and "colonic type" intestinal metaplasia of the human stomach, and their relationship to the histogenetic types of gastric adenocarcinoma. Acta Pathol Microbiol Scand [A] 86A:351-355
54. Segura DI, Montero C (1983) Histochemical characterization of different types of intestinal metaplasia in gastric mucosa. Cancer (Phila) 52:498-503
55. Jass JR, Filipe MI (1979) A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study. Histopathology (Oxf) 3:191-199
56. Tatematsu M, Tsukamoto T, Inada K (2003) Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 94:135-141
57. Porter EM, van Dam E, Valore EV, et al (1997) Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect Immun 65:2396-2401
58. Porter EM, Liu L, Oren A, et al (1997) Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun 65:2389-2395
59. Inada K, Nakanishi H, Fujimitsu Y, et al (1997) Gastric and intestinal mixed and solely intestinal types of intestinal metaplasia in the human stomach. Pathol Int 47:831-841
60. Yuasa H, Inada K, Watanabe H, et al (2002) A phenotypic shift from gastric-intestinal to solely intestinal cell types in intestinal metaplasia in rat stomach following treatment with X-rays. J Toxicol Pathol 15:85-93
61. Nozaki K, Shimizu N, Tsukamoto T, et al (2002) Reversibility of heterotopic proliferative glands in glandular stomach of Helicobacter pylori-infected Mongolian gerbils on eradication. Jpn J Cancer Res 93:374-381
62. Hattori T, Fujita S (1979) Tritiated thymidine autoradiographic study on histogenesis and spreading of intestinal metaplasia in human stomach. Pathol Res Pract 164:224-237
63. Hattori T, Helpap B, Gedigk P (1982) The morphology and cell kinetics of pseudopyloric glands. Virchows Arch B Cell Pathol Mol Pathol 39:31-40
64. Karam SM, Leblond CP (1993) Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell. Anat Rec 236:259-279
65. Ponder BA, Schmidt GH, Wilkinson MM, et al (1985) Derivation of mouse intestinal crypts from single progenitor cells. Nature (Lond) 313:689-691
66. Tatematsu M, Fukami H, Yamamoto M, et al (1994) Clonal analysis of glandular stomach carcinogenesis in C3H/HeN<->BALB/c chimeric mice treated with N-methyl-N-nitrosourea. Cancer Lett 83:37-42
67. Tatematsu M, Masui T, Fukami H, et al (1996) Primary monoclonal and secondary polyclonal growth of colon neoplastic lesions in C3H/HeN<=>BALB/ c chimeric mice treated with 1, 2-dimethylhydrazine immunohistochemical detection of C3H strain-specific antigen and simple sequence length polymorphism analysis of DNA. Int J Cancer 66:234-238
68. Inada K, Tanaka H, Nakanishi H, et al (2001) Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach. Virchows Arch 439:14-20
69. Mallo GV, Rechreche H, Frigerio JM, et al (1997) Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 74:35-44
70. Silberg DG, Sullivan J, Kang E, et al (2002) Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 122:689-696
71. Silberg DG, Swain GP, Suh ER, et al (2000) Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119:961-971
72. Soubeyran P, Andre F, Lissitzky JC, et al (1999) Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology 117:1326-1338
73. Eda A, Osawa H, Yanaka I, et al (2002) Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 37:94-100
74. Mutoh H, Hakamata Y, Sato K, et al (2002) Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 294:470-479
75. Mizoshita T, Inada K, Tsukamoto T, et al (2001) Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa-with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer 4:185-191
76. Silberg DG, Furth EE, Taylor JK, et al (1997) CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology 113:478-486
77. Almeida R, Silva E, Santos-Silva F, et al (2003) Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 199:36-40
78. Mizoshita T, Tsukamoto T, Inada K, et al (2004) Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa. Pathol Int 54:392-400
79. Ishii Y, Rex M, Scotting PJ, et al (1998) Region-specific expression of chicken Sox2 in the developing gut and lung epithelium: regulation by epithelial-mesenchymal interactions. Dev Dyn 213:464-475
80. Yasugi S (2000) Epithelial cell differentiation during stomach development. Hum Cell 13: 177-184
81. Tsukamoto T, Inada K, Tanaka H, et al (2004) Down regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia. J Cancer Res Clin Oncol 130:135-145
82. Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma: an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31-49
83. Nakamura K, Sugano H, Takagi K (1968) Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann 59:251-258
84. Correa P (1988) A human model of gastric carcinogenesis. Cancer Res 48:3554-3560
85. Correa P (1995) Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol 19(suppl 1):S37-S43
86. Egashira Y, Shimoda T, Ikegami M (1999) Mucin histochemical analysis of minute gastric differentiated adenocarcinoma. Pathol Int 49:55-61
87. Koseki K, Takizawa T, Koike M, et al (2000) Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer (Phila) 89:724-732
88. Kawachi H, Takizawa T, Eishi Y, et al (2003) Absence of either gastric or intestinal pheno-type in microscopic differentiated gastric carcinomas. J Pathol 199:436-446
89. Tatematsu M, Furihata C, Katsuyama T, et al (1983) Independent induction of intestinal metaplasia and gastric cancer in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res 43:1335-1341
90. Tatematsu M, Katsuyama T, Furihata C, et al (1984) Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl-N'-nitro-N-nitrosoguani-dine or methylnitrosourea in rats. Gann 75:957-965
91. Tatematsu M, Furihata C, Katsuyama T, et al (1986) Gastric and intestinal phenotypic expressions of human signet ring cell carcinomas revealed by their biochemistry, mucin histochemistry, and ultrastructure. Cancer Res 46:4866-4872
92. Hattori T (1986) Development of adenocarcinomas in the stomach. Cancer (Phila) 57: 1528-1534
93. Tatematsu M, Ichinose M, Miki K, et al (1990) Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn 40:494-504
94. Kushima R, Hattori T (1993) Histogenesis and characteristics of gastric-type adenocarcinomas in the stomach. J Cancer Res Clin Oncol 120:103-111
95. Nomura S, Kaminishi M, Sugiyama K, et al (1998) Clonal analysis of isolated intestinal metaplastic glands of stomach using X linked polymorphism. Gut 42:663-668
96. Saito A, Shimoda T, Nakanishi Y, et al (2001) Histologic heterogeneity and mucin phenotypic expression in early gastric cancer. Pathol Int 51:165-171
97. Furihata C, Iwasaki Y, Sugimura T, et al (1973) Differentiation of pepsinogen-producing cells in the fundic and pyloric mucosa of developing rats. Cell Differ 2:179-189
98. Furihata C, Saito D, Fujiki H, et al (1980) Purification and characterization of pepsinogens and a unique pepsin from rat stomach. Eur J Biochem 105:43-50
99. Furihata C, Kawachi T, Sugimura T (1972) Premature induction of pepsinogen in developing rat gastric mucosa by hormones. Biochem Biophys Res Commun 47:705-711
100. Furihata C, Sasajima K, Kazama S, et al (1975) Changes in pepsinogen isozymes in stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N- nitrosoguanidine. J Natl Cancer Inst 55:925-930
101. Tatematsu M, Saito D, Furihata C, et al (1980) Initial DNA damage and heritable permanent change in pepsinogen isoenzyme pattern in the pyloric mucosae of rats after short-term administration of N-methyl-N'-nitro-N- nitrosoguanidine. J Natl Cancer Inst 64:775-781
102. Tatematsu M, Furihata C, Hirose M, et al (1977) Changes in pepsinogen isozymes in stomach cancers induced in Wistar rats by N-methyl-N'-nitro-N- nitrosoguanidine and in transplantable gastric carcinoma (SG2B). J Natl Cancer Inst 58:1709-1716
103. Tatematsu M, Furihata C, Mera Y, et al (1986) Immunohistochemical demonstration of induction of pyloric glands with low pepsinogen 1 (Pg 1) content in rat stomach by N-methyl-N'-nitro-N-nitrosoguanidine. Jpn J Cancer Res 77:238-243
104. Tatematsu M, Furihata C, Katsuyama T, et al (1987) Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N'-nitro-N-nitrosoguanidine. J Natl Cancer Inst 78:771-777
105. Tatematsu M, Aoki T, Inoue T, et al (1988) Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis (Oxf) 9:495-498
106. Tatematsu M, Mutai M, Aoki T, et al (1989) Proliferation kinetics of pepsinogen altered pyloric gland cells in rats treated with N-methyl-N'-nitro-N- nitrosoguanidine. Carcinogenesis (Oxf) 10:907-911
107. Tatematsu M, Ozaki K, Mutai M, et al (1990) Enhancing effects of various gastric carcinogens on development of pepsinogen-altered pyloric glands in rats. Carcinogenesis (Oxf) 11:1975-1978
108. Tatematsu M, Ichinose M, Tsukada S, et al (1993) DNA methylation of the pepsinogen 1 gene during rat glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine or catechol. Carcinogenesis (Oxf) 14:1415-1419
109. Yamamoto M, Furihata C, Fujimitsu Y, et al (1997) Dose-dependent induction of both pepsinogen-altered pyloric glands and adenocarcinomas in the glandular stomach of C3H mice treated with N-methyl-N-nitrosourea. Jpn J Cancer Res 88:238-244
110. Yamamoto M, Furihata C, Ogiu T, et al (2002) Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea. Cancer Lett 179:121-132
111. Tajima K, Tominaga S (1985) Dietary habits and gastro-intestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 76:705-716
112. Tsugane S, Tsuda M, Gey F, et al (1992) Cross-sectional study with multiple measurements of biological markers for assessing stomach cancer risks at the population level. Environ Health Perspect 98:207-210
113. Joossens JV, Hill MJ, Elliott P, et al (1996) Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol 25:494-504
114. Kono S, Hirohata T (1996) Nutrition and stomach cancer. Cancer Causes Control 7:41-55
115. Tatematsu M, Takahashi M, Fukushima S, et al (1975) Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N- nitrosoguanidine or 4-nitroquinoline-1-oxide. J Natl Cancer Inst 55:101-106
116. Takahashi M, Nishikawa A, Furukawa F, et al (1994) Dose-dependent promoting effects of sodium chloride (NaCl) on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis (Oxf) 15:1429-1432
117. Furihata C, Ohta H, Katsuyama T (1996) Cause and effect between concentration-dependent tissue damage and temporary cell proliferation in rat stomach mucosa by NaCl, a stomach tumor promoter. Carcinogenesis (Oxf) 17:401-406
118. Nozaki K, Shimizu N, Inada K, et al (2002) Synergistic promoting effects of Helicobacter pylori infection and high-salt diet on gastric carcinogenesis in Mongolian gerbils. Jpn J Cancer Res 93:1083-1089
119. Comfort MW, Kelsey MP, Berkson J (1947) Gastric acidity before and after the development of carcinoma of the stomach. J Natl Cancer Inst 7:367-373
120. Gilbertsen VA, Knatterud GL (1967) Gastric analysis as a screening measure for cancer of the stomach. Cancer (Phila) 20:127-133
121. Segal HL, Samloff IM (1973) Gastric cancer-increased frequency in patients with achlorhydria. Am J Dig Dis 18:295-299
122. Fischer A, Clagett OT, McDonald JR (1947) Coexistent duodenal ulcer and gastric malignancy. Surgery (St. Louis) 21:168-174
123. Portis SA, Jaffe RH (1938) A study of peptic ulcer based on necropsy records. JAMA 110:6-13
124. Bralow SP, Gruenstein M, Meranze DR, et al (1970) Adenocarcinoma of glandular stomach and duodenum in Wistar rats ingesting N-methyl-N'-nitro-N- nitrosoguanidine, histopathology and associated secretory changes. Cancer Res 30:1215-1222
125. Tatsuta M, Itoh T, Okuda S, et al (1977) Effect of prolonged administration of gastrin on experimental carcinogenesis in rat stomach induced by N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res 37:1808-1810
126. Tatsuta M, Itoh T, Okuda S, et al (1980) Effects of gastrin and histamine on gastric carcinogenesis induced in rats by N-methyl-N'-nitro-N- nitrosoguanidine. Eur J Cancer 16: 631-638
127. Tatsuta M, Yamamura H, Taniguchi H, et al (1982) Gastrin protection against chemically induced gastric adenocarcinomas in Wistar rats: histopathology of the glandular stomach and incidence of gastric adenocarcinoma. J Natl Cancer Inst 69:59-66
128. Tahara E, Haizuka S (1975) Effect of gastro-entero-pancreatic endocrine hormones on the histogenesis of gastric cancer in rats induced by N-methyl-N'-nitro-N-nitrosoguanidine; with special reference to development of scirrhous gastric cancer. Gann 66:421-426
129. Perkin DM, Muir CS, Whelon SL, et al (1992) Cancer incidence in five continents. IARC Scientific Publication 120, vol 6. International Agency for Research on Cancer, Lyon, pp 1-1033
130. Furukawa H, Iwanaga T, Koyama H, et al (1982) Effect of sex hormones on carcinogenesis in the stomachs of rats. Cancer Res 42:5181-5182
131. Palli D, Cipriani F, Decarli A, et al (1994) Reproductive history and gastric cancer among post-menopausal women. Int J Cancer 56:812-815
132. Singh S, Poulsom R, Wright NA, et al (1997) Differential expression of oestrogen receptor and oestrogen inducible genes in gastric mucosa and cancer. Gut 40:516-520
133. Sica V, Nola E, Contieri E, et al (1984) Estradiol and progesterone receptors in malignant gastrointestinal tumors. Cancer Res 44:4670-4674
134. Tokunaga A, Nishi K, Matsukura N, et al (1986) Estrogen and progesterone receptors in gastric cancer. Cancer (Phila) 57:1376-1379
135. Wu CW, Chi CW, Chang TJ, et al (1990) Sex hormone receptors in gastric cancer. Cancer (Phila) 65:1396-1400
136. Yokozaki H, Takekura N, Takanashi A, et al (1988) Estrogen receptors in gastric adenocarcinoma: a retrospective immunohistochemical analysis. Virchows Arch A Pathol Anat Histopathol 413:297-302
137. Uehara Y, Takahashi T, Kojima O, et al (1986) Peroxidase-antiperoxidase staining for estrogen and progesterone in scirrhous type of gastric cancer: possible existence of the estrogen receptor. Jpn J Surg 16:245-249
138. Wu CW, Chang HM, Kao HL, et al (1992) The nontransformed progesterone and estrogen receptors in gastric cancer. Gastroenterology 102:1639-1646
139. Karat D, Brotherick I, Shenton BK, et al (1999) Expression of oestrogen and progesterone receptors in gastric cancer: a flow cytometric study. Br J Cancer 80:1271-1274
140. Moyer MP, Armstrong A, Aust JB, et al (1986) Effects of gastrin, glutamine, and somatostatin on the in vitro growth of normal and malignant human gastric mucosal cells. Arch Surg 121:285-288
141. Tatsuta M, Iishi H, Baba M, et al (1989) Enhancement by somatostatin of experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N- nitrosoguanidine in Wistar rats. Cancer Res 49:5534-5536
142. Dharmsathaphorn K, Binder HJ, Dobbins JW (1980) Somatostatin stimulates sodium and chloride absorption in the rabbit ileum. Gastroenterology 78:1559-1565
143. Shapiro B, Pienta K, Heldsinger A, et al (1981) Somatostatin is an agonist and noncompetitive antagonist of gastrin in oxyntic cell function. Endocrinology 109:1117-1121
144. Iishi H, Tatsuta M, Baba M, et al (1993) Enhancement by thyroxine of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Br J Cancer 68: 515-518
145. Adeniyi KO, Olowookorun MO (1989) Gastric acid secretion and parietal cell mass: effects of thyroidectomy and thyroxine. Am J Physiol 256:G975-G978
146. Feurle GE, Muller B, Ohnheiser G, et al (1985) Action of neurotensin on size, composition, and growth of pancreas and stomach in the rat. Regul Pept 13:53-62
147. Feurle GE, Muller B, Rix E (1987) Neurotensin induces hyperplasia of the pancreas and growth of the gastric antrum in rats. Gut 28(suppl):19-23
148. Tatsuta M, Iishi H, Baba M, et al (1989) Promotion by neurotensin of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Cancer Res 49:843-846
149. Gespach C, Hui Bon Hoa D, Rosselin G (1983) Regulation by vasoactive intestinal peptide, histamine, somatostatin-14 and-28 of cyclic adenosine monophosphate levels in gastric glands isolated from the guinea pig fundus or antrum. Endocrinology 112:1597-1606
150. Emami S, Gespach C, Forgue-Lafitte ME, et al (1983) Histamine and VIP interactions with receptor-cyclic AMP systems in the human gastric cancer cell line HGT-1. Life Sci 33: 415-423
151. Iishi H, Tatsuta M, Baba M, et al (1992) Enhancement by vaso-active intestinal peptide of gastric carcinogenesis induced by N-methyl-N'-nitro-N- nitrosoguanidine in rats. Int J Cancer 50:649-652
152. Kobori O, Vuillot MT, Martin F (1982) Growth responses of rat stomach cancer cells to gastro-entero-pancreatic hormones. Int J Cancer 30:65-67
153. Tatsuta M, Iishi H, Baba M, et al (1995) Promotion by substance P of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Cancer Lett 96: 99-103
154. Stalsberg H, Taksdal S (1971) Stomach cancer following gastric surgery for benign conditions. Lancet 2:1175-1177
155. Schrumpf E, Serck-Hanssen A, Stadaas J, et al (1977) Mucosal changes in the gastric stump 20-25 years after partial gastrectomy. Lancet 2:467-469
156. Savage A, Jones S (1979) Histological appearances of the gastric mucosa 15-27 years after partial gastrectomy. J Clin Pathol 32:179-186
157. Saegesser F, James D (1972) Cancer of the gastric stump after partial gastrectomy (Billroth II principle) for ulcer. Cancer (Phila) 29:1150-1159
158. Furihata C, Takezawa R, Matsushima T, et al (1987) Potential tumor-promoting activity of bile acids in rat glandular stomach. Jpn J Cancer Res 78:32-39
159. Kobori O, Shimizu T, Maeda M, et al (1984) Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methyl-N'-nitro-N- nitrosoguanidine in Wistar rats. J Natl Cancer Inst 73:853-861
160. Kobori O, Watanabe J, Shimizu T, et al (1984) Enhancing effect of sodium taurocholate on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumorigenesis in rats. Gann 75: 651-654
161. Salmon RJ, Laurent M, Thierry JP (1984) Effect of taurocholic acid feeding on methyl-nitro-N-nitroso-guanidine induced gastric tumors. Cancer Lett 22:315-320
162. Yamaguchi S, Tatematsu M, Furihata C, et al (1990) Effects of bile acids on development of pepsinogen-altered pyloric glands in rats. Cancer Lett 55:129-134
163. Salmon RJ, Merle S, Zafrani B, et al (1985) Gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine: role of gastrectomy and duodenal reflux. Jpn J Cancer Res 76: 167-172
164. Sano C, Kumashiro R, Saito T, et al (1984) Promoting effect of partial gastrectomy on carcinogenesis in the remnant stomach of rats after oral administration of N-methyl-N'-nitro-N-nitrosoguanidine. Oncology 41:124-128
165. Kondo K, Suzuki H, Nagayo T (1984) The influence of gastro-jejunal anastomosis on gastric carcinogenesis in rats. Gann 75:362-369
166. Langhans P, Heger RA, Hohenstein J, et al (1981) Gastric stump carcinoma-new aspects deduced from experimental results. Scand J Gastroenterol Suppl 67:161-164
167. Kobayasi S, Tatematsu M, Ogawa K, et al (1991) Reversibility of adenomatous hyperplasia in the gastric stump after diversion of bile reflux in rats. Carcinogenesis (Oxf) 12: 1437-1443
168. Mason RC (1986) Duodenogastric reflux in rat gastric carcinoma. Br J Surg 73:801-803
169. Tatematsu M, Imaeda, K (1989) Tumors of the glandular stomach. In: Stinson SF, Schuller HM, Reznik GK (eds) Atlas of tumor pathology of the Fischer rat. CRC Press, Boca Raton, FL, pp 95-115
170. Imai T, Kobayasi S, Rodrigues MA, et al (1993) Reduction of cell proliferative activities of gastric stump adenomatous hyperplasias after bile reflux diversion in rats. Carcinogenesis (Oxf) 14:1765-1769
171. Asaka M, Kimura T, Kudo M, et al (1992) Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 102:760-766
172. Uemura N, Okamoto S, Yamamoto S, et al (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345:784-789
173. Cao X, Tsukamoto T, Nozaki K, et al (2002) Earlier Helicobacter pylori infection increases the risk for the N-methyl-N-nitrosourea-induced stomach carcinogenesis in Mongolian gerbils. Jpn J Cancer Res 93:1293-1298
174. Malaty HM, El-Kasabany A, Graham DY, et al (2002) Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. Lancet 359:931-935
175. Correa P, Fontham ET, Bravo JC, et al (2000) Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy. J Natl Cancer Inst 92:1881-1888
176. Shimizu N, Ikehara Y, Inada K, et al (2000) Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils. Cancer Res 60:1512-1514
177. Watanabe T, Tada M, Nagai H, et al (1998) Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 115:642-648
178. Honda S, Fujioka T, Tokieda M, et al (1998) Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils. Cancer Res 58:4255-4259
179. Hirayama F, Takagi S, Iwao E, et al (1999) Development of poorly differentiated adenocarcinoma and carcinoid due to long-term Helicobacter pylori colonization in Mongolian gerbils. J Gastroenterol 34:450-454
180. Sugano H, Nakamura K, Kato Y (1982) Pathological studies of human gastric cancer. Acta Pathol Jpn 32(suppl 2):329-347
181. Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma, 2nd English edn. Gastric Cancer 1:10-24
182. Tatematsu M, Hasegawa R, Ogawa K, et al (1992) Histogenesis of human stomach cancers based on assessment of differentiation. J Clin Gastroenterol 14(suppl 1):S1-S7
183. Yoshikawa A, Inada Ki K, Yamachika T, et al (1998) Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression. Gastric Cancer 1:134-141
184. Tajima Y, Shimoda T, Nakanishi Y, et al (2001) Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions. Oncology 61:212-220
185. Bamba M, Sugihara H, Kushima R, et al (2001) Time-dependent expression of intestinal phenotype in signet ring cell carcinomas of the human stomach. Virchows Arch 438:49-56
186. Mizoshita T, Tsukamoto T, Nakanishi H, et al (2003) Expression of Cdx2 and the phenotype of advanced gastric cancers: relationship with prognosis. J Cancer Res Clin Oncol 129:727-734
187. Mizoshita T, Inada K, Tsukamoto T, et al (2004) Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells. J Cancer Res Clin Oncol 130:29-36
188. Hattori T, Hosokawa Y, Fukuda M, et al (1984) Analysis of DNA ploidy patterns of gastric carcinomas of Japanese. Cancer (Phila) 54:1591-1597
189. Korenaga D, Haraguchi M, Okamura T, et al (1989) DNA ploidy and tumor invasion in human gastric cancer. Histopathologic differentiation. Arch Surg (Phila) 124:314-318
190. Hattori T, Sugihara H, Fukuda M, et al (1986) DNA ploidy patterns of minute carcinomas in the stomach. Jpn J Cancer Res 77:276-281
191. Kuniyasu H, Yasui W, Kitadai Y, et al (1992) Frequent amplification of the c-met gene in scirrhous type stomach cancer. Biochem Biophys Res Commun 189:227-232
192. Nakatani H, Sakamoto H, Yoshida T, et al (1990) Isolation of an amplified DNA sequence in stomach cancer. Jpn J Cancer Res 81:707-710
193. Yokota J, Yamamoto T, Miyajima N, et al (1988) Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. Oncogene 2:283-287
194. Yoshida K, Tsuda T, Matsumura T, et al (1989) Amplification of epidermal growth factor receptor (EGFR) gene and oncogenes in human gastric carcinomas. Virchows Arch B Cell Pathol Mol Pathol 57:285-290
195. Tsujimoto H, Sugihara H, Hagiwara A, et al (1997) Amplification of growth factor receptor genes and DNA ploidy pattern in the progression of gastric cancer. Virchows Arch 431: 383-389
196. Kusakabe M, Yokoyama M, Sakakura T, et al (1988) A novel methodology for analysis of cell distribution in chimeric mouse organs using a strain specific antibody. J Cell Biol 107:257-265
197. Lee GH, Nomura K, Kanda H, et al (1991) Strain specific sensitivity to diethylnitrosamine-induced carcinogenesis is maintained in hepatocytes of C3H/HeN in equilibrium with C57BL/6N chimeric mice. Cancer Res 51:3257-3260
198. Yamachika T, Inada K, Fujimitsu Y, et al (1997) Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch 431:103-110
199. Tatematsu M, Katsuyama T, Fukushima S, et al (1980) Mucin histochemistry by paradoxical concanavalin A staining in experimental gastric cancers induced in Wistar rats by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline 1-oxide. J Natl Cancer Inst 64:835-843
200. Tatematsu M, Katsuyama T, Furihata C, et al (1990) Cellular differentiation and histogenesis of rat glandular stomach cancers. Jpn J Cancer Res 81:760-767
201. Yuasa H, Hirano K, Kodama H, et al (1994) Immunohistochemical demonstration of intestinal-type alkaline phosphatase in stomach tumors induced by N-methyl-N ¢-nitro-N-nitrosoguanidine in rats. Jpn J Cancer Res 85:897-903
202. Matsukuma A, Mori M, Enjoji M (1990) Sulphomucin-secreting intestinal metaplasia in the human gastric mucosa. An association with intestinal-type gastric carcinoma. Cancer (Phila) 66:689-694
203. Sugihara H, Hattori T, Fukuda M, et al (1987) Cell proliferation and differentiation in intra-mucosal and advanced signet ring cell carcinomas of the human stomach. Virchows Arch A Pathol Anat Histopathol 411:117-127
204. Fujimori Y, Akamatsu T, Ota H, et al (1995) Proliferative markers in gastric carcinoma and organoid differentiation. Hum Pathol 26:725-734
205. Salenius P (1962) On the ontogenesis of the human gastric epithelial cells. A histologic and histochemical study. Acta Anat (Basel) 50(suppl 46):1-76
206. Bai YQ, Yamamoto H, Akiyama Y, et al (2002) Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 176:47-55
207. Seno H, Oshima M, Taniguchi MA, et al (2002) CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: prognostic implications. Int J Oncol 21: 769-774
208. Li XL, Eishi Y, Bai YQ, et al (2004) Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int J Oncol 24:257-263
209. Kono S, Ikeda M, Tokudome S, et al (1988) A case-control study of gastric cancer and diet in northern Kyushu, Japan. Jpn J Cancer Res 79:1067-1074
210. Weisburger JH (1991) Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants, and carotenoids. Am J Clin Nutr 53:226S-237S
211. Fujita Y, Yamane T, Tanaka M, et al (1989) Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N ¢-nitro-N-nitrosoguanidine in mouse duodenum. Jpn J Cancer Res 80:503-505
212. Narisawa T, Fukaura Y (1993) A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 84:1007-1009
213. Mukhtar H, Das M, Khan WA, et al (1988) Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7, 12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice. Cancer Res 48:2361-2365
214. Wang ZY, Huang MT, Ferraro T, et al (1992) Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res 52:1162-1170
215. Conney AH, Wang ZY, Huang MT, et al (1992) Inhibitory effect of green tea on tumorigenesis by chemicals and ultraviolet light. Prev Med 21:361-369
216. Xu Y, Ho CT, Amin SG, et al (1992) Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants. Cancer Res 52:3875-3879
217. Katiyar SK, Agarwal R, Zaim MT, et al (1993) Protection against N-nitrosodiethylamine and benzo[a]pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea. Carcinogenesis (Oxf) 14:849-855
218. Yamane T, Takahashi T, Kuwata K, et al (1995) Inhibition of N-methyl-N ¢-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach. Cancer Res 55:2081-2084
219. Komori A, Yatsunami J, Okabe S, et al (1993) Anticarcinogenic activity of green tea polyphenols. Jpn J Clin Oncol 23:186-190
220. Hibasami H, Komiya T, Achiwa Y, et al (1998) Induction of apoptosis in human stomach cancer cells by green tea catechins. Oncol Rep 5:527-529
221. Ahmad N, Feyes DK, Nieminen AL, et al (1997) Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst 89:1881-1886
222. Okabe S, Ochiai Y, Aida M, et al (1999) Mechanistic aspects of green tea as a cancer preventive: effect of components on human stomach cancer cell lines. Jpn J Cancer Res 90: 733-739
223. Nozaki K, Shimizu N, Ikehara Y, et al (2003) Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils. Cancer Sci 94:235-239
224. Labenz J, Blum AL, Bayerdorffer E, et al (1997) Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis. Gastroenterology 112: 1442-1447
225. Naef AP, Savary M, Ozzello L (1975) Columnar-lined lower esophagus: an acquired lesion with malignant predisposition. Report on 140 cases of Barrett's esophagus with 12 adenocarcinomas. J Thorac Cardiovasc Surg 70:826-835
226. Tsugane S, Sasazuki S, Kobayashi M, et al (2004) Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women. Br J Cancer 90: 128-134