Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment [1]

Epilepsia

Volumn 47, Issue 2, 2006, Pages 449-

  Basic, Silvio ^a   Hajnsek, Sanja ^a   Poljakovic, Zdravka ^a   Basic, Marela ^a  

^a KBC Zagreb   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTICONVULSIVE AGENT; CEFTRIAXONE; CHLORPROMAZINE; DILTIAZEM; ERYTHROMYCIN; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; MULTIDRUG RESISTANCE PROTEIN 1; NICARDIPINE; NIFEDIPINE; PROPRANOLOL; RESERPINE; STEROID; TRIFLUOPERAZINE; VALPROIC ACID; VERAPAMIL;

DNA POLYMORPHISM; DRUG EFFECT; EPILEPSY; GENE FUNCTION; GENETIC ASSOCIATION; HUMAN; LETTER; PRIORITY JOURNAL; TREATMENT OUTCOME;

ANTICONVULSANTS; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; EPILEPSY; GENES, MDR; HUMANS; P-GLYCOPROTEIN; PHARMACOGENETICS; POLYMORPHISM, GENETIC; RESEARCH DESIGN; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; VALPROIC ACID;

EID: 33645289956     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00444_1.x     Document Type: Letter

References (8)

1. Sills GJ Mohanraj R Butler E et al. Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia 2005 46 643 647.
2. Loscher W Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 2005 76 22 76.
3. Weiss J Kerpen CJ Lindenmaier H et al. Interaction of antiepileptic drugs with human P-glycoprotein in vitro. J Pharmacol Exp Ther 2003 307 262 267.
4. Kwan P Brodie JM. Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia 2005 46 224 235.
5. Regesta G Tanganelli P. Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res 1999 34 109 122.
6. Sisodiya SM Lin WR Harding BN et al. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 2002 125 22 31.
7. Siddiqui A Kerb R Weale ME et al. Association of multidrug resistence in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 2003 348 1442 1448.
8. Tishler DM Weinberg KI Hinton DR et al. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995 36 1 6.