Protective effects of ginkgo leaf extracts on neurons in spinal cord after ischemia-reperfusion injury in rabbits

Journal of Chinese Integrative Medicine

Volumn 4, Issue 2, 2006, Pages 181-184

  Fan, Li Hong ^a   Wang, Kun Zheng ^a   Cheng, Bin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Apoptosis; Ginkgo leaf extracts; Lipid peroxidation; Reperfusion injury; Spinal cord

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; GINKGO BILOBA EXTRACT; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; HINDLIMB; LIPID PEROXIDATION; LOCOMOTION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PLANT LEAF; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY; SPINAL CORD ISCHEMIA; UPREGULATION;

ANIMALS; APOPTOSIS; DRUGS, CHINESE HERBAL; FEMALE; FREE RADICAL SCAVENGERS; GINKGO BILOBA; LIPID PEROXIDATION; MALE; NEURONS; PROTECTIVE AGENTS; RABBITS; RANDOM ALLOCATION; REPERFUSION INJURY; SPINAL CORD; SPINAL CORD ISCHEMIA; SUPEROXIDE DISMUTASE;

EID: 33645278656     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20060214     Document Type: Article

References (9)

1. Zivin JA, DeGirolami U. Spinal cord infarction: a highly reproducible stroke model. Stroke, 1980, 11(2): 200-202.
2. Johnson SH, Kraimer JM, Graeber GM. Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits. Stroke, 1993, 24(10): 1547-1553.
3. Basu S, Hellberg A, Ulus AT, et al. Biomarkers of free radical injury during spinal cord ischemia. FEBS Lett, 2001, 508(1): 36-38.
4. Hayashi T, Sakurai M, Abe K, et al. Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia. Stroke, 1998, 29(5): 1007-1012.
5. Polster BM, Fiskum G. Mitochondrial mechanisms of neural cell apoptosis. J Neurochem, 2001, 90(6): 1281-1289.
6. Chinese source. 2003, 1(2): 116-118.
7. Xin W, Wei T, Chen C, et al. Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents. Toxicology, 2000, 148(2-3): 103-110.
8. Smith JV, Burdick AJ, Golik P, et al. Anti-apoptotic properties of Ginkgo biloba extract EGb761 in differentiated PC12 cells. Cell Mol Biol, 2002, 48(6): 699-707.
9. Unal I, Gursoy-Ozdemir Y, Bolay H, et al. Chronic daily administration of selegiline and EGb761 increased brain's resistance to ischemia in mice. Brain Res, 2001, 917(2): 174-181.