Delivery of TEM β-lactamase by gene-transformed Lactococcus lactis subsp. lactis through cervical cell monolayer

International Journal of Pharmaceutics

Volumn 313, Issue 1-2, 2006, Pages 29-35

  Kaushal, Gagan ^a   Trombetta, Louis ^a   Ochs, Raymond S ^a   Shao, Jun ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Bioavailability; C 33A; Lactococcus lactis; Normal flora; Protein delivery; TEM lactamase; Vaginal delivery

Indexed keywords

BETA LACTAMASE; BETA LACTAMASE TEM; MANNITOL; PROPRANOLOL; TRYPAN BLUE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM TRANSFORMATION; CELL CULTURE; CELL STRUCTURE; CELL VIABILITY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; ELECTRON MICROSCOPY; GENE TRANSFER; HUMAN; HUMAN CELL; LACTOCOCCUS LACTIS; PLASMID; PRIORITY JOURNAL; UTERINE CERVIX;

BACTERIAL ADHESION; BETA-LACTAMASES; CELL LINE, TUMOR; CERVIX UTERI; EPITHELIAL CELLS; FEMALE; HUMANS; LACTOCOCCUS LACTIS; TIME FACTORS; TRANSFORMATION, BACTERIAL;

EID: 33645277792     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.01.013     Document Type: Article

References (13)

1. M. Furuhjelm, C. Karlgren, and K. Carlstrom Intravaginal administration of conjugated estrogens in post-menopausal women Int. J. Gynecol. Obstet. 7 1980 335 339
2. T. Mukherjee, E. Squillante, M. Gillespie, and J. Shao Transepithelial electrical resistance is not a reliable measurement of the Caco-2 monolayer integrity in the transwell Drug Deliv. 11 2004 11 18
3. P.H. Pouwels, R.J. Leer, M. Shaw, M.J.H. den Bak-Glashouwer, F.D. Tielen, E. Smit, B. Martinez, J. Jore, and P.L. Conway Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes Int. J. Food Microbiol. 41 1998 155 167
4. G. Reid, A.W. Bruce, J.G. McGroarty, K.J. Cheng, and J.W. Costerton Is there a role for lactobacilli in prevention of urogenital and intestinal infections? Clin. Microbiol. Rev. 3 1990 335 344
5. J.L. Richardson, and L. Illum The vaginal route of peptide and protein drug delivery Adv. Drug Deliv. Rev. 8 1992 341 366
6. S. Salminen, A. von Wright, L. Morelli, P. Marteau, D. Brassart, W.M. de Vos, R. Fonden, M. Saxelin, K. Collins, G. Mogensen, S.E. Birkeland, and T. Mattila-Sandholm Demonstration of safety of probiotics - a review Int. J. Food Microbiol. 44 1998 93 106
7. J. Shao, and G. Kaushal Normal flora: living vehicles for non-invasive protein drug delivery Int. J. Pharm. 286 2004 117 124
8. M. Sibakov, T. Koivula, A. von Wright, and I. Palva Secretion of TEM β-lactamase with signal sequences isolated from the chromosome of Lactococcus lactis subsp. lactis Appl. Environ. Microbiol. 57 1991 341 348
9. A. Sullivan, and C.E. Nord The place of probiotics in human intestinal infections Int. J. Antimicrob. Agents 20 2002 313 319
10. G.W. Tannock The lactic microflora of pigs, mice and rats B.J.B. Wood The Lactic Acid Bacteria in Health and Disease 1992 Elsevier Applied Science London and New York 21 48
11. E.M. Tuomola, and S.J. Salminen Adhesion of some probiotic and dairy Lactobacillus strains to Caco-2 cell cultures Int. J. Food Microbiol. 41 1998 45 51
12. E.M. Tuomola, A.C. Ouwehand, and S.J. Salminen Human ileostomy glycoproteins as a model for small intestinal mucus to investigate adhesion of probiotics Lett. Appl. Microbiol. 28 1999 159 163
13. M.M. Velraeds, H.C. van der Mei, G. Reid, and H.J. Busscher Inhibition of initial adhesion of uropathogeinc Enterococcus faecalis by biosurfactants from Lactobacillus isolates Appl. Environ. Microbiol. 62 1996 1958 1963