Nitric oxide might be involved in the chloroquine-improved insulin sensitivity: Old treatment for global danger [2]

Diabetes Research and Clinical Practice

Volumn 72, Issue 1, 2006, Pages 110-111

  Ahmed, M H ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Chloroquine; Insulin; Nitric oxide

Indexed keywords

CHLOROQUINE; INSULIN; NITRIC OXIDE;

CALCIUM CELL LEVEL; ENDOTHELIUM CELL; GLUCOSE TOLERANCE; HUMAN; IN VITRO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; LETTER;

ANTIMALARIALS; CHLOROQUINE; ENDOTHELIUM, VASCULAR; HUMANS; INSULIN; NITRIC OXIDE;

EID: 33645277123     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2005.09.009     Document Type: Letter

References (8)

1. M.H. Ahmed, N. Ashton, and R.J. Balment The effect of chloroquine on renal function and vasopressin secretion: a nitric oxide-dependent effect J. Pharmacol. Exp. Ther. 304 2003 156 161
2. H.C. Gerstein, K.E. Thorpe, D.W. Taylor, and R.B. Haynes The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas - a randomized trial Diabetes Res. Clin. Pract. 55 2002 209 219
3. K.A. Asamoah, D.A. Robb, and B.L. Furman Chronic chloroquine treatment enhances insulin release in rats Diabetes Res. Clin. Pract. 9 1990 273 278
4. G.D. Smith, T.A. Amos, R. Mahler, and T.J. Peters Effect of chloroquine on insulin and glucose homoeostasis in normal subjects and patients with non-insulin-dependent diabetes mellitus Br. Med. J. (Clin. Res. Ed.). 21 1987 465 467
5. D. Ghigo, E. Aldieri, R. Todde, C. Costamagna, G. Garbarino, and G. Pescarmona Chloroquine stimulates nitric oxide synthesis in murine, porcine, and human endothelial cells J. Clin. Invest. 102 1998 595 605
6. H.H. Schmidt, T.D. Warner, K. Ishii, H. Sheng, and F. Murad Insulin secretion from pancreatic B cells caused by l-arginine-derived nitrogen oxides Science 255 1992 721 723
7. S.R. Smukler, L. Tang, M.B. Wheeler, and A.M.F. Salapatek Exogenous nitric oxide and endogenous glucose-stimulated {beta}-cell nitric oxide augment insulin release Diabetes 51 2002 3450 3460
8. M.P. Guarino, N.C. Correia, W.W. Lautt, and M.P. Macedo Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver Am. J. Physiol. Gastrointest. Liver Physiol. 287 2004 527 532