Protection of endothelial cells by dextran sulfate in rats with thrombotic microangiopathy

Journal of the American Society of Nephrology

Volumn 16, Issue 10, 2005, Pages 2997-3005

  Eto, Nobuaki ^a   Kojima, Ichiro ^a   Uesugi, Noriko ^b   Inagi, Reiko ^c   Miyata, Toshio ^c   Fujita, Toshiro ^a   Johnson, Richard J ^d   Shankland, Stuart J ^e   Nangaku, Masaomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d UNIVERSITY OF FLORIDA   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DEXTRAN SULFATE; ANTICOAGULANT AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY PERFUSION; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTHELIUM CELL; HISTOPATHOLOGY; KIDNEY FAILURE; KIDNEY INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL ARTERY; RENAL PROTECTION; THROMBOTIC THROMBOCYTOPENIC PURPURA; UREA NITROGEN BLOOD LEVEL; ANIMAL; DISEASE MODEL; DRUG EFFECT; MALE; THROMBOSIS; WISTAR RAT;

ANIMALS; ANTICOAGULANTS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; MALE; RATS; RATS, WISTAR; THROMBOSIS;

EID: 33645270140     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2005020137     Document Type: Article

References (38)

1. Nangaku M, Alpers CE, Pippin J, Shankland SJ, Adler S, Kurokawa K, Couser WG, Johnson RJ: A new model of renal microvascular endothelial injury. Kidney Int 52: 182-194, 1997
2. Kimura M, Fujigaki Y, Ohtake T, Furuya R, Hishida A, Kaneko E: A patient with thrombotic microangiopathy accompanied by glomerular subendothelial electron dense deposits. Am J Nephrol 18: 155-159, 1998
3. Meehan SM, Limsrichamrern S, Manaligod JR, Junsanto T, Josephson MA, Thistlethwaite JR, Haas M: Platelets and capillary injury in acute humoral rejection of renal allografts. Hum Pathol 34: 533-540, 2003
4. Nangaku M, Shankland SJ, Couser WG, Johnson RJ: A new model of renal microvascular injury. Curr Opin Nephrol Hypertens 7: 457-462, 1998
5. Johnson RJ: What mediates progressive glomerulosclerosis? The glomerular endothelium comes of age. Am J Pathol 151: 1179-1181, 1997
6. Iruela-Arispe L, Gordon K, Hugo C, Duijvestijn AM, Claffey KP, Reilly M, Couser WG, Alpers CE, Johnson RJ: Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis. Am J Pathol 147: 1715-1727, 1995
7. Lee LK, Meyer TW, Pollock AS, Lovett DH: Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest 96: 953-964, 1995
8. Shimizu A, Kitamura H, Masuda Y, Ishizaki M, Sugisaki Y, Yamanaka N: Rare glomerular capillary regeneration and subsequent capillary regression with endothelial cell apoptosis in progressive glomerulonephritis. Am J Pathol 151: 1231-1239, 1997
9. Shimizu A, Masuda Y, Kitamura H, Ishizaki M, Sugisaki Y, Yamanaka N: Recovery of damaged glomerular capillary network with endothelial cell apoptosis in experimental proliferative glomerulonephritis. Nephron 79: 206-214, 1998
10. Habib R, Gagnadoux MF, Broyer M: [Hemolytic-uremic syndrome in children and arterial hypertension]. Arch Mal Coeur Vaiss 74: 37-43, 1981
11. Loirat C, Sonsino E, Varga Moreno A, Pillion G, Mercier JC, Beaufils F, Mathieu H: Hemolytic-uremic syndrome: An analysis of the natural history and prognostic features. Acta Paediatr Scand 73: 505-514, 1984
12. Segonds A, Louradour N, Sue JM, Orfila C: Postpartum hemolytic uremic syndrome: A study of three cases with a review of the literature. Clin Nephrol 12: 229-242, 1979
13. Argyle JC, Hogg RJ, Pysher TJ, Silva FG, Siegler RL: A clinicopathological study of 24 children with hemolytic uremic syndrome. A report of the Southwest Pediatric Nephrology Study Group. Pediatr Nephrol 4: 52-58, 1990
14. Richardson SE, Karmali MA, Becker LE, Smith CR: The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections. Hum Pathol 19: 1102-1108, 1988
15. Fortin MC, Schurch W, Cardinal H, Hebert MJ: Complement factor H deficiency in acute allograft glomerulopathy and post-transplant hemolytic uremic syndrome. Am J Transplant 4: 270-273, 2004
16. Hugo C, Nangaku M, Shankland SJ, Pichler R, Gordon K, Amieva MR, Couser WG, Furthmayr H, Johnson RJ: The plasma membrane-actin linking protein, ezrin, is a glomerular epithelial cell marker in glomerulogenesis, in the adult kidney and in glomerular injury. Kidney Int 54: 1934-1944, 1998
17. Dang CT, Magid MS, Weksler B, Chadburn A, Laurence J: Enhanced endothelial cell apoptosis in splenic tissues of patients with thrombotic thrombocytopenic purpura. Blood 93: 1264-1270, 1999
18. Shibata S, Sasaki T, Harpel P, Fillit H: Autoantibodies to vascular heparan sulfate proteoglycan in systemic lupus erythematosus react with endothelial cells and inhibit the formation of thrombin-antithrombin III complexes. Clin Immunol Immunopathol 70: 114-123, 1994
19. Gotte M: Syndecans in inflammation. FASEB J 17: 575-591, 2003
20. Platt JL, Vercellotti GM, Lindman BJ, Oegema TR Jr, Bach FH, Dalmasso AP: Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J Exp Med 171: 1363-1368, 1990
21. Silvestri L, Baker JR, Roden L, Stroud RM: The C1q inhibitor in serum is a chondroitin 4-sulfate proteoglycan. J Biol Chem 256: 7383-7387, 1981
22. Almeda S, Rosenberg RD, Bing DH: The binding properties of human complement component C1q. Interaction with mucopolysaccharides. J Biol Chem 258: 785-791, 1983
23. Maillet F, Petitou M, Choay J, Kazatchkine MD: Structure-function relationships in the inhibitory effect of heparin on complement activation: Independency of the anti-coagulant and anti-complementary sites on the heparin molecule. Mol Immunol 25: 917-923, 1988
24. Wuillemin WA, te Velthuis H, Lubbers YT, de Ruig CP, Eldering E, Hack CE: Potentiation of C1 inhibitor by glycosaminoglycans: Dextran sulfate species are effective inhibitors of in vitro complement activation in plasma. J Immunol 159: 1953-1960, 1997
25. Manotham K, Tanaka T, Matsumoto M, Ohse T, Miyata T, Inagi R, Kurokawa K, Fujita T, Nangaku M: Evidence of tubular hypoxia in the early phase in the remnant kidney model. J Am Soc Nephrol 15: 1277-1288, 2004
26. Kim YG, Suga SI, Kang DH, Jefferson JA, Mazzali M, Gordon KL, Matsui K, Breiteneder-Geleff S, Shankland SJ, Hughes J, Kerjaschki D, Schreiner GF, Johnson RJ: Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy. Kidney Int 58: 2390-2399, 2000
27. Nangaku M, Alpers CE, Pippin J, Shankland SJ, Kurokawa K, Adler S, Morgan BP, Johnson RJ, Couser WG: CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats. J Am Soc Nephrol 9: 590-597, 1998
28. Nangaku M, Alpers CE, Pippin J, Shankland SJ, Kurokawa K, Adler S, Johnson RJ, Couser WG: Renal microvascular injury induced by antibody to glomerular endothelial cells is mediated by C5b-9. Kidney Int 52: 1570-1578, 1997
29. Dawes J: Measurement of the affinities of heparins, naturally occurring glycosaminoglycans, and other sulfated polymers for antithrombin III and thrombin. Anal Biochem 174: 177-186, 1988
30. Laumonier T, Walpen AJ, Maurus CF, Mohacsi PJ, Matozan KM, Korchagina EY, Bovin NV, Vanhove B, Seebach JD, Rieben R: Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells. Transplantation 76: 838-843, 2003
31. McCurry KR, Kooyman DL, Alvarado CG, Cotterell AH, Martin MJ, Logan JS, Platt JL: Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1: 423-427, 1995
32. Fiorante P, Banz Y, Mohacsi PJ, Kappeler A, Wuillemin WA, Macchiarini P, Roos A, Daha MR, Schaffner T, Haeberli A, Mazmanian GM, Rieben R: Low molecular weight dextran sulfate prevents complement activation and delays hyperacute rejection in pig-to-human xenotransplantation models. Xenotransplantation 8: 24-35, 2001
33. Laumonier T, Mohacsi PJ, Matozan KM, Banz Y, Haeberli A, Korchagina EY, Bovin NV, Vanhove B, Rieben R: Endothelial cell protection by dextran sulfate: A novel strategy to prevent acute vascular rejection in xenotransplantation. Am J Transplant 4: 181-187, 2004
34. Park PW, Reizes O, Bernfield M: Cell surface heparan sulfate proteoglycans: Selective regulators of ligand-receptor encounters. J Biol Chem 275: 29923-29926, 2000
35. Tumova S, Woods A, Couchman JR: Heparan sulfate proteoglycans on the cell surface: Versatile coordinators of cellular functions. Int J Biochem Cell Biol 32: 269-288, 2000
36. Nishinaga M, Shimada K: [Heparan sulfate proteoglycan of endothelial cells: Homocysteine suppresses anticoagulant active heparan sulfate in cultured endothelial cells]. Rinsho Byori 42: 340-345, 1994
37. Rops AL, van der Vlag J, Lensen JF, Wijnhoven TJ, van den Heuvel LP, van Kuppevelt TH, Berden JH: Heparan sulfate proteoglycans in glomerular inflammation. Kidney Int 65: 768-785, 2004
38. Raats CJ, Van Den Born J, Berden JH: Glomerular heparan sulfate alterations: Mechanisms and relevance for proteinuria. Kidney Int 57: 385-400, 2000