The impact of menopause and lifestyle factors on blood and bone lead levels among female former smelter workers: The Bunker Hill study

American Journal of Industrial Medicine

Volumn 49, Issue 3, 2006, Pages 143-152

  Potula, Vijayalakshmi ^a,b   Kaye, Wendy ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

Author keywords

Bone; Epidemiology; Hormone replacement therapy; Lead; Lifestyle factors; Menopause; Smelter occupation; Women; X ray fluorescence

Indexed keywords

ALCOHOL; CADMIUM 109; GRAPHITE; LEAD;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BONE LEVEL; CALCANEUS; CIGARETTE SMOKING; EDUCATION; FEMALE; FEMALE WORKER; HORMONE SUBSTITUTION; HUMAN; LEAD BLOOD LEVEL; LIFESTYLE; MAJOR CLINICAL STUDY; MENOPAUSE; MINER; OCCUPATIONAL EXPOSURE; PREMENOPAUSE; REPRODUCTION; SMELTER; TIBIA; UNITED STATES; X RAY FLUORESCENCE;

ADULT; AGE FACTORS; CALCANEUS; EDUCATIONAL STATUS; FEMALE; HUMANS; LEAD; LIFE STYLE; LINEAR MODELS; MENOPAUSE; MIDDLE AGED; MINING; OCCUPATIONS; SMOKING; TIBIA;

EID: 33645243026     PISSN: 02713586     EISSN: 10970274     Source Type: Journal    
DOI: 10.1002/ajim.20262     Document Type: Article

References (42)

1. Agency for Toxic Substances and Disease Registry. Study of female former workers at a lead smelter: An examination of the possible association of lead exposure with decreased bone density and other health outcomes. Atlanta: US Department of Health and Human Services; 1997. Publication No.: PB97-144844.
2. Aitken JM, Hart DM, Lindsay R. 1973. Oestrogen replacement therapy for prevention of osteoporosis after oophorectomy. BMJ 3(5879):515-518.
3. Annest JL, Pirkle JL, Makuc D, Neese JW, Bayse DD, Kovar MG. 1983. Chronological trend in blood lead levels between 1976 and 1980. N Engl J Med 308(23):1373-1377.
4. Brody DJ, Pirkle JL, Kramer RA, Flegal KM, Matte TD, Gunter EW, et.al. 1994. Blood lead levels in the US population. Phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III, 1988 to 1991). [erratum appears in JAMA 1995; 274(2):130.] JAMA 272(4):277-283.
5. Burger DE, Milder FL, Morsillo PR, et al. 1990. Automated bone lead analysis by K-X-ray fluorescence for the clinical environment. Basic Life Sci 55:287-292.
6. Christiansen C, Christensen MS, Jensen J, McNair P, Hagen C, Stocklund KE, et.al. 1980. Prevention of early post-menopausal bone mineral loss. Controlled 2-year study of 315 women. Ugeskr Laeger 142(44):2896-2901.
7. Christiansen C, Christensen MS, Transbol I. 1981. Bone mass in post-menopausal women after withdrawal of oestrogen/gestagen replacement therapy. Lancet 1(8218):459-461.
8. Elders PJ, Netelenbos JC, Lips P, van Ginkel FC, van der Stell PF. 1988. Accelerated vertebral bone loss in relation to the menopause: A cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age. Bone Miner 5:11-19.
9. Environmental Protection Agency. Review of worker exposures and health evaluations at the Bunker Hill facility, Kellogg, Idaho. BCL October 1992 Sections 1.0, 3.0, and 5.0.
10. Field CS, Ory SJ, Wahner HW, Hermann RR, Judd HL, Riggs BL. 1993. Preventive effects of transdermal 17 beta-estradiol on osteoporotic changes after surgical menopause: A two-year placebo-controlled trial. Am J Obstet Gynecol 168(1):114-121.
11. Genant HK, Cann CE, Ettinger B, Gordan GS. 2000. Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy. Clin Orthop 372: 3-8.
12. Gordon CL, Chettle DR, Webber CE. 1993. An improved instrument for the in vivo detection of bone lead. Br J Ind Med 50:637-641.
13. Grandjean P, Olsen NB, Hollnagel H. 1981. Influence of smoking and alcohol consumption on blood lead levels. Int Arch Occup Environ Health 48(4):391-397.
14. Grasmick C, Huel G, Moreau T, Sarmini H. 1985. The combined effect of tobacco and alcohol consumption on the level of lead and cadmium in blood. Sci Total Environ 41(3):207-217.
15. Gulson BL, Mahaffey KR, Mizon KJ, Korsch MJ, Cameron MA, Vimpani G. 1995. Contribution of tissue lead to blood lead in adult female subjects based on stable lead isotope methods. J Lab Clin Med 125:703-712.
16. Harlan WR. 1988. The relationship of blood lead levels to blood pressure in the US population. Environ Health Perspect 78:9-13.
17. Hense HW, Filipiak B, Novak L, Stoeppler M. 1992. Non-occupational determinants of blood lead concentrations in a general population, [erratum appears in Int J Epidemiol 1992; 21(6):1199] Int J Epidemiol 21(4):753-762.
18. Hu FB, Grodstein F. 2002. Postmenopausal hormone therapy and the risk of cardiovascular disease: The epidemiologic evidence. Am J Cardiol 90:26F-29F.
19. Hu H, Rabinowitz M, Smith D. 1998. Bone lead as a biological marker in epidemiologic studies of chronic toxicity: Conceptual paradigms. Env Health Perspec 106:1-8.
20. Johnston C, Hui SL, Witt RM, et al. 1985. Early menopausal changes in bone mass and sex steroids. J Clin Endocrinol Metab 61:905-911.
21. Kim R, Aro A, Rotnitzky A, et al. 1995. K X-ray fluorescence measurements of bone lead concentration: The analysis of low-level data. Phys Med Biol 40:1475-1485.
22. Kosnett MJ, Becker CE, Osterloh JD, Kelly TJ, Pasta DJ. 1994. Factors influencing bone lead concentration in a suburban community assessed by noninvasive K X-ray fluorescence. JAMA 271(3):197-203.
23. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC. 1976. Long-term prevention of post-menopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment. Lancet 1(7968):1038-1041.
24. Muldoon SB, Cauley JA, Kuller LH, Scott J, Rohay J. 1994. Lifestyle and sociodemographic factors as determinants of blood lead levels in elderly women. Am J Epidemiol 139(6):599-608.
25. Nash D, Silbergeld E, Magder L, Stolley P. 1998. Menopause, hormone replacement therapy (HRT), and blood lead levels among adult women from NHANES III, 1988-1994 [abstract]. Am J Epidemiol 147: S93.
26. Nash D, Magder L, Lustberg M, Sherwin RW, Rubin RJ, Kaufmann RB, Silbergeld EK. 2003. Blood lead, blood pressure, and hypertension in perimenopausal and postmenopausal women, [comment]. JAMA 289(12):1523-1532.
27. Nilas L, Christiansen C. 1988. Rates of bone loss in normal women: Evidence of accelerated trabecular bone loss after menopause. Eur J Clin Invest 18:529-534.
28. Nilsson U. Atewell R, Christoffersson JO, et al. 1991. Kinetics of lead in bone after end of occupational exposure. Pharmacol Toxicol 69:477-484.
29. Potula V, Howard Hu. 1996. Occupational and lifestyle determinants of blood lead levels among men in Madras, India. Int J Occup Environ Health 2:1-4.
30. Pounds GJ, Long GJ, Rosen JF. 1991. Cellular and molecular toxicity of lead in bone. Env Health Perspect 91:17-32.
31. Richelson LS, Wahner HW, Melton LJ III, Riggs BL. 1984. Relative contributions of aging and estrogen deficiency to post-menopausal bone loss. N Engl J Med 311(20):1273-1275.
32. Riggs BL, Melton LJ III. 1986. Involutional osteoporosis. N Engl J Med 314(26):1676-1986.
33. Rothman KJ, Greenland S. 1998. Modern epidemiology, Second edition. Philadelphia, PA: Lippincott-Raven Publishers, p247.
34. Ruegsegger P, Dambacher MA, Ruegsegger E, Fischer JA, Anliker M. 1984. Bone loss in premenopausal women. A cross-sectional and longitudinal study using quantitative computed tomography. J Bone Surg 66:1015-1023.
35. Shaper AG, Pocock SJ, Walker M, Wale CJ, Clayton B, Delves HT, et al. 1982. Effects of alcohol and smoking on blood lead in middle-aged British men. Br Med J (Clin Res Ed) 284(6312):299-302.
36. Silbergeld EK, Schwartz J, Mahaffey K. 1988. Lead and osteoporosis: Mobilization of lead from bone in women. Environ Res 47:79-94.
37. Silbergeld EK, Sauk J, Somerman M, Todd A, McNeill F, Fowler B, et al. 1993. Lead in bone: Storage site, exposure source, and target organ. Neurotoxicology 14:225-236.
38. Stokes L, Letz R, Gerr F, Kolczak M, McNeill FE, Chettle DR, et.al. 1998. Neurotoxicity in young adults 20 years after childhood exposure to lead: The Bunker Hill experience. Occup Environ Med 55(8):507-516.
39. Symansky E, Hertz-Piccioto I. 1995. Blood lead levels in relation to menopause, smoking, and pregnancy history. Am J Epidemiol 141(11):1047-1058.
40. Todd AC, McNeill FE, Fowler BA. 1992. In vivo X-ray fluorescence of lead in bone. Environ Res 59:326-335.
41. Webber CE, Chettle DR, Bowins RJ, et al. 1995. Hormone replacement therapy may reduce the return of endogenous lead from bone to the circulation. Environ Health Perspect 103:1150-1153.
42. Weyerman M, Brenner H. 1998. Factors affecting bone demineralization and blood lead levels of postmenopausal women. A population-based study from Germany. Environ Res 76:19-25.