Inhibition of angiotensin II- and endothelin-1-stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblasts

Fundamental and Clinical Pharmacology

Volumn 19, Issue 6, 2005, Pages 677-685

  Ohsawa, Masami ^a   Ohuchi, Nozomi ^a,d   Taniguchi, Yumiko ^b   Kizawa, Yasuo ^a   Koike, Katsuo ^c   Iwamoto, Keishi ^c   Hayashi, Kazuhiko ^a   Murakami, Hajime ^c  

^a NIHON UNIVERSITY   (Japan)

^b KINJO GAKUIN UNIVERSITY   (Japan)

^c TOHO UNIVERSITY   (Japan)

^d JOSAI INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Angiotensin II; Endothelin 1; Extracellular signal regulated kinases; Proliferation; Rabbit gingival fibroblasts

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II; CANDESARTAN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SARALASIN; TAK 044; 1,3 BUTADIENE DERIVATIVE; CYCLO(TRP ASP PRO VAL LEU); CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; ENZYME INHIBITOR; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NITRILE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; FIBROBLAST; GINGIVA; NONHUMAN; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM;

ANGIOTENSIN II; ANIMALS; BLOTTING, WESTERN; BUTADIENES; CELL PROLIFERATION; ENDOTHELIN-1; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FLAVONOIDS; GINGIVA; MAP KINASE KINASE KINASES; NITRILES; PEPTIDES, CYCLIC; RABBITS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SARALASIN;

EID: 33645242057     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2005.00372.x     Document Type: Article

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